Supercharge Your Innovation With Domain-Expert AI Agents!

Single-celled graphical chip capable of generating high magnetic field gradients based on magnetic filtering

A high-magnetic field, single-cell technology, applied in the field of biological microsystems, can solve the problems of complex manufacturing process and difficult operation of single-cell patterned chips, and achieve the effects of improving efficiency, simple manufacturing process and shortening cycle.

Active Publication Date: 2013-03-27
TSINGHUA UNIV
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to overcome the problems of complex manufacturing process and difficult operation of the current single-cell patterned chip, and provide a single-cell patterned chip based on magnetic field filtering to form a high magnetic field gradient

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Single-celled graphical chip capable of generating high magnetic field gradients based on magnetic filtering
  • Single-celled graphical chip capable of generating high magnetic field gradients based on magnetic filtering
  • Single-celled graphical chip capable of generating high magnetic field gradients based on magnetic filtering

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0016] The preferred embodiments will be described in detail below in conjunction with the accompanying drawings.

[0017] The single-cell patterned chip based on magnetic field filtering to form a high magnetic field gradient proposed by the present invention is composed of a magnetic source, a magnetic filter and a biocompatible modification layer, such as Figure 1-2 As shown, the magnetic source is made of NdFeB, and the diameter of the small hole array is 10 μm. The biocompatible modification layer is titanium dioxide, which can ensure that the activity of cells adsorbed on it will not be affected.

[0018] According to the magnetic field boundary condition theory: If a ferromagnet 2 with a small hole array 4 with high relative permeability is added above the magnetic source 1, because the magnetic field line enters the medium with high relative permeability from the medium with low relative permeability , the magnetic field line will deflect to the boundary after enteri...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
diameteraaaaaaaaaa
Login to View More

Abstract

The invention discloses a single-celled graphical chip capable of generating high magnetic field gradients based on magnetic filtering, belonging to the technical field of a biological micro-system. The chip is formed by sequentially overlapping a magnetic source, a magnetic filter and a biocompatibility modification layer, wherein the magnetic filter is a permanent magnet with hole arrays. In the chip disclosed by the invention, magnetic trap arrays with high gradients are formed via the magnetic source and the magnetic filter, and then magnetic particles are absorbed towards the center of the trap; once entering the magnetic field, the magnetic particles cannot break away from the restriction of the magnetic field without an enough force; and the diameter of the formed single magnetic trap is close to the diameter of a single cell so that one trap only absorbs one cell and the formed cell arrays are single-celled arrays. According to the invention, the cell patterning efficiency is improved and the cell patterning period is shortened. The most outstanding characteristic of the single-celled graphical chip in the invention is that the fabrication process of the chip is very simple.

Description

technical field [0001] The invention belongs to the technical field of biological microsystems, and in particular relates to a single-cell patterned chip based on magnetic field filtering to form a high magnetic field gradient. Background technique [0002] The data obtained in most traditional biological experiments are the statistical average results of a large number of cells. However, due to the different ion channel states, the dynamic performance of the cytoskeleton, and the differences in the internal network of cells, cells have individual differences. Traditional biological experiments often ignore the rich information carried by the differences of individual cells. Relevant studies have shown that the strong adaptability and drug resistance of cancer cells come from the individual differences of cancer cells. Therefore, targeted research on heterogeneous cells is very important for exploring the mechanism of cancer cells and developing anticancer drugs. Single-ce...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/34
Inventor 任大海尤政王俊谢锦宇
Owner TSINGHUA UNIV
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com