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Medicine for treating accelerated hypertension

A high blood pressure, rapid progressive technology, applied in the field of drugs for the treatment of rapidly progressive hypertension, can solve the problems of poor control of safe dosage, different pathogenesis, cerebral infarction, etc., to prevent renal insufficiency of perfusion and reduce secondary renal function The effect on the risk of failure

Inactive Publication Date: 2014-03-12
威海市妇女儿童医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above treatment schemes have the following defects in the treatment of rapidly progressive hypertension: ①The course of rapidly progressive hypertension and hypertension is not uniform. ②The pathogenesis of rapidly progressive hypertension and hypertension are different, and rapidly progressive hypertension is mostly caused by arterial intimal hyperplasia and fibrinoid necrosis; ③As a kind of hypertensive emergency, rapid venous access is often used in clinical treatment Rapidly reduce blood pressure with fast-acting drugs. At this time, if Pinggan Xifeng Zhishang is used again, it is actually superimposed with the drug effect of western medicine, making the safe dosage of fast-acting drugs such as sodium nitroprusside or alfonate even more difficult to control. , causing blood perfusion disorders in the brain, heart, and kidneys, and inducing myocardial infarction and cerebral infarction; ④ Rapidly progressive hypertension is related to the dysfunction of the autoregulatory function of the circulation, which has not been paid attention to by Western medicine and traditional Chinese medicine.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1, the weight ratio of raw materials: loofah 10g, earthworm 8g, scutellaria chinensis 8g, Aescin chinensis 6g, papaya 6g, pangolin 8g, tallow 6g, cassia twig 3g, stone gallbladder 3g.

Embodiment 2

[0027] Example 2, the weight ratio of raw materials: 20g of loofah, 15g of earthworm, 15g of Xueli, 10g of Aescin, 10g of Chinese papaya, 15g of pangolin, 10g of Chinese tallow, 6g of cassia twig, and 6g of gallbladder.

Embodiment 3

[0028] Example 3, the weight ratio of raw materials: luffa 15g, earthworm 10g, 10g of mulberry, 8g of aescin, 8g of Chinese papaya, 10g of pangolin, 8g of Sapium chinensis, 5g of cassia twig, and 5g of gallbladder.

[0029] When in use, add water to decoct the traditional Chinese medicine loofah, earthworm, succulent lily, aescin, papaya, pangolin, tallow, stone gallbladder, and cassia twig twice, combine the filtrate, and take it in the morning and evening. Or make dosage forms such as oral liquid and use.

[0030] The effective combination and coordination of the above drugs can effectively achieve the purpose of treating rapidly progressive hypertension with less side effects. The above results are fully proved by the clinical data, and the relevant data are as follows, wherein the drug used in the study is the weight ratio of the bulk drug in Example 3.

[0031] 1 Objects and methods.

[0032] 1.1 Objects: 42 patients with rapidly progressive hypertension diagnosed betwe...

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PUM

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Abstract

The invention discloses a medicine for treating accelerated hypertension to solve the problem of treatment of accelerated hypertension. The medicine is characterized by being prepared from the following raw materials in parts by weight: 10-20 parts of luffa vegetable sponge, 8-15 parts of earthworm, 8-15 parts of ficus pumila, 6-10 parts of paris polyphylla, 6-10 parts of pawpaw, 8-15 parts of pangolin scales, 6-10 parts of Chinese tallowtree root-bark, 3-6 parts of cassia twig and 3-6 parts of stone ball. Clinical experiments prove that the medicine has the characteristics of good curative effect on accelerated hypertension and higher safety, and deserves clinical application and promotion.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a medicine for treating rapidly progressive hypertension. Background technique [0002] Rapidly progressive hypertension, which is more common in young and middle-aged patients, can develop from slowly progressive hypertension, and can also be malignant hypertension onset. Blood pressure increased significantly, diastolic blood pressure can reach more than 130mmhg. Its clinical manifestations progress rapidly, and proteinuria, hematuria, azotemia or uremia will appear soon, and heart failure will occur in a short period of time, and vision will decrease rapidly, regardless of papilledema. The pathogenesis of rapidly progressive hypertension is extremely complex, and it is likely to be related to the dysfunction of autoregulation in the circulation. The more mainstream theories include overregulation or arteriolar spasm theory, and autoregulation rupture theory. The s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/896A61P9/12
Inventor 张晓君李世桥
Owner 威海市妇女儿童医院