Trace drug delivery and changing device utilizing electroosmosis/pressure technology and application and manufacturing method of trace drug delivery and changing device

Abstract

The invention relates to a trace drug delivery and changing device utilizing the electroosmosis / pressure technology and an application and manufacturing method of the trace drug delivery and changing device. The device comprises a glass microelectrode, a first PE (polyethylene) tube, a second PE tube and a third PE tube. The glass microelectrode comprises a thick section, a thin section and a neck, wherein the neck is a joint between the thick section and the thin section. The diameters of the first PE tube and the second PE tube are smaller than that of the third PE tube. The first PE tube, the second PE tube and the third PE tube are inserted at openings of the thick section. A gap between the thick section and each of the first PE tube, the second PE tube and the third PE tube is sealed. By the multifunctional trace drug delivery and changing device which is capable of drug delivery and changing, animal anesthesia and supporting of a drug delivery core tube by hands during drug delivery are avoided, positioning errors of traditional drug delivery are avoided, guide tube blocking in traditional drug delivery is eliminated, and trace drug delivery can be performed by selectively utilizing electroosmosis or pressure injection. In addition, the whole device is simple and cheap to manufacture, and more convenient in drug delivery.

Description

【Technical field】 [0001] The invention belongs to the field of biomedical experiments, and in particular relates to an electroosmosis / pressure technology micro-dosing dressing changing device and its use and manufacturing method. 【Background technique】 [0002] Brain localized injection technology plays a very important role in the study of nerve bundles and neural circuits, the neural mechanism of drug action, and neuropharmacology research. Neuroscience research in the 21st century involves multidisciplinary and multi-technical cross-applications. Therefore, many neuroscience researchers must apply brain localization injection technology. The application of brain positioning injection technology can inject tracers into specific areas of the brain, observe and analyze the fiber connections and neural circuits between nerve nuclei; it can also inject micro-dose drugs into brain nuclei or brain regions, such as receptor agonists , antagonists, protein inhibitors, etc., by ob...

AI Technical Summary

Problems solved by technology

[0004] The above drug delivery methods have the following disadvantages: (1) It is difficult to ensure accurate positioning, especially for small nuclei

Then, if the researcher still assumes the inaccurate "2mm" to be the exact 2mm, even if the cannula embedded in the brain has undergone strict stereotaxic positioning, the positioning will be inaccurate after the drug delivery core tube is inserted.

(2) Microdosing often requires more expensive equipment

Because if the core is "capped" and cannot be pulled out, the core tube for subsequent administration cannot be inserted, and subsequent experiments will not be possible

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