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Traditional Chinese medicine preparation for treating essential hypotension and preparation method of traditional Chinese medicine preparation

A technology for essential hypotension and traditional Chinese medicine preparations, which can be used in pharmaceutical formulations, cardiovascular system diseases, medical preparations containing active ingredients, etc.

Active Publication Date: 2014-09-17
陕西步长高新制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] For this reason, we have applied for the following 3 invention patents for this traditional Chinese medicine composition, the publication numbers of which are CN1471928A, CN1733027A and CN1733257A respectively, and the publication dates are 2006.01.04, 2006.02.15 and 2006.02.15 respectively. The above invention patent documents It is disclosed and protected from the aspects of different component dosage, preparation process, quality control method and dosage form in the prescription, but in the actual application process, we found that the effect of the Chinese patent medicine made by the above preparation method is not ideal, and The patent of this application is to further optimize the preparation process through a large number of experiments, and find the best preparation parameters. The pharmacological experiment effect is more significant, and the purpose of improving the stability and bioavailability of the preparation is a creative development. A traditional Chinese medicine preparation for treating essential hypotension

Method used

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  • Traditional Chinese medicine preparation for treating essential hypotension and preparation method of traditional Chinese medicine preparation
  • Traditional Chinese medicine preparation for treating essential hypotension and preparation method of traditional Chinese medicine preparation
  • Traditional Chinese medicine preparation for treating essential hypotension and preparation method of traditional Chinese medicine preparation

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Effect test

Embodiment 1

[0075] ⑴Use 12g of donkey-hide gelatin and 12g of Gastrodia elata, and grind them into fine powder for later use;

[0076] (2) Take 180g of ephedra, use acid water with a weight ratio of 8 times that of the medicinal material, and a pH value of 4.0, heat and extract twice, each time for 2 hours, filter, keep the dregs for use, combine the filtrate and concentrate, dry and pulverize into a dry paste powder, spare;

[0077] (3) 120 g of red ginseng is crushed into coarse powder, and percolation extraction is carried out with ethanol with a concentration of 75%, the percolation liquid is collected and ethanol is recovered, concentrated and dried and crushed into dry cream powder for subsequent use, and the dregs are retained for future use;

[0078] (4) Take 360g of Citrus aurantium and 300g of cassia twig, soak in water with a weight ratio of 10 times that of the medicinal material, and then steam distill for 1.5 h to collect the volatile oil and clathrate it with β-cyclodextrin...

Embodiment 2

[0083] ⑴Use 12g of donkey-hide gelatin and 12g of Gastrodia elata, and grind them into fine powder for later use;

[0084] (2) Take 180g of ephedra, use acid water with a weight ratio of 6 times that of the medicinal material and a pH value of 5.0, heat and extract once, 3 hours each time, filter, keep the dregs for use, combine the filtrate and concentrate, dry and pulverize into a dry paste powder, spare;

[0085] (3) Pulverize 120 g of red ginseng into coarse powder, carry out percolation extraction with ethanol with a concentration of 90%, collect percolation liquid and recover ethanol, concentrate, dry and pulverize into dry cream powder for later use, and keep the dregs for future use;

[0086] (4) Take 360g of Aurantium citrus and 300g of cassia twig, soak in water with a weight ratio of 8 times that of the medicinal material, and steam distill for 2 hours to collect the volatile oil and clathrate it with β-cyclodextrin with a weight ratio of 6 times that of the volatil...

Embodiment 3

[0091] ⑴Use 12g of donkey-hide gelatin and 12g of Gastrodia elata, and grind them into fine powder for later use;

[0092] (2) Take 180g of ephedra, use acid water with a weight ratio of 10 times that of the medicinal material and a pH value of 4.0, heat and extract 3 times, each time for 1 hour, filter, keep the medicinal residue, combine the filtrate and concentrate, dry and pulverize into a dry cream powder ,spare;

[0093] (3) Pulverize 120 g of red ginseng into coarse powder, carry out percolation extraction with ethanol with a concentration of 80%, collect percolation liquid and recover ethanol, concentrate and dry and pulverize into dry cream powder for later use, and keep the dregs for future use;

[0094] (4) Take 360g of Aurantium citrus and 300g of cassia twig, soak in water with a weight ratio of 9 times the weight of the medicinal materials, and then use steam distillation for 0.5 h to collect the volatile oil and clathrate it with β-cyclodextrin with a weight rat...

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Abstract

The invention relates to a traditional Chinese medicine preparation for treating essential hypotension and a preparation method of the traditional Chinese medicine preparation. The traditional Chinese medicine preparation is prepared by taking 120 parts of red ginseng, 360 parts of immature bitter orange, 180 parts of Chinese ephedra, 300 parts of ramulus cinnamomi, 300 parts of prepared rehmannia root, 300 parts of radix ophiopogonis, 400 parts of Chinese starjasmine stem, 540 parts of hairyvein agrimony, 12 parts of donkey-hide gelatin, and 32 parts of rhizoma gastrodiae as raw materials, extracting and purifying and adopting pharmaceutically acceptable auxiliary materials. The traditional Chinese medicine preparation comprises granules, tablets, hard capsules, pills, and the like. A clinical pharmacodynamics experiment verifies that the traditional Chinese medicine preparation has a more significant curative effect in essential hypotension treatment.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation for treating essential hypotension and a preparation method thereof, belonging to the technical field of medicine preparation. Background technique [0002] Hypotension is a common and frequently-occurring disease that occurs widely all over the world. According to incomplete statistics, the incidence of hypotension is about 4%, and it can reach 10% in the elderly population. Patients suffer from hypotension for a long time, which can lead to a great decline in body function, and may also lead to cerebral infarction and myocardial infarction. The mortality rate of hypotensive people is also higher than that of normal people, which has brought serious problems to patients, families and society, which cannot be ignored . At present, there is no particularly effective treatment method in this field for the treatment of such diseases. Patients take Western medicine for a long time for t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K36/8988A61P9/02
Inventor 赵步长赵超
Owner 陕西步长高新制药有限公司
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