Reworking method of cefpirome sulfate

Abstract

The invention discloses a reworking method of cefpirome sulfate. The reworking method comprises the following steps of: 1) dissolving the cefpirome sulfate to be reworked in a certain amount of water; 2) dripping an organic base for dissolution, regulating the PH value to 4.0-8.0, and setting the reaction temperature at 0 DEG C-30 DEG C; 3) enabling the solution after dissolution to pass through a column loaded with an adsorbent, and collecting filtrate; 4) adding activated carbon into the filtrate, performing decolorization reaction for 30min, and filtering; 5) regulating the PH value of the filtrate after decolorization to 1.2-2.4; 6) adding a quantitative crystallizing agent into the filtrate for crystallization, controlling the crystallization temperature at 0 DEG C-30 DEG C, and stirring for 2-4h till the end of reaction; 7) filtering, and washing with one solution or a mixed solution of acetone and alcohol; and 8) drying at the temperature of 45 DEG C-55 DEG C to obtain the cefpirome sulfate. According to the reworking method disclosed by the invention, the unqualified cefpirome sulfate can be effectively reworked and refined to produce a qualified product, and the cost can be further reduced.

Description

technical field [0001] The invention relates to a reworking method of cefpirome sulfate. Background technique [0002] Cefpirome sulfate is the fourth generation of broad-spectrum cephalosporin antibiotics. It has the characteristics of broad-spectrum and high-efficiency inhibition of β-lactamase. It is clinically used for the treatment of patients with moderate and severe infections. Its synthetic route is relatively complicated and expensive. Unqualified color, content, impurity, sterility, visible foreign matter, etc. may sometimes occur due to other reasons in the preparation process, and the unqualified cefpirome sulfate is discarded, which is relatively wasteful. Contents of the invention [0003] For overcoming above-mentioned shortcoming, the object of the present invention is to provide a kind of reworking method that can effectively refine unqualified cefpirome sulfate into qualified product, and the rework method of the cefpirome sulfate of cost reduction. [0...

AI Technical Summary

Problems solved by technology

[0002] Cefpirome sulfate is the fourth generation of broad-spectrum cephalosporin antibiotics. It has the characteristics of broad-spectrum and high-efficiency inhibition of β-lactamase. It is clinically used for the treatment of patients with moderate and severe infections. Its synthetic route is relatively complicated and expensive. During the preparation process, unqualified color, content, impurities, sterility, visible foreign matter, etc. may sometimes occur due to other reasons, and the unqualified cefpirome sulfate is discarded, which is more wasteful