Cefuroxime and tazobactam pharmaceutical composition
A technology of cefuroxime and tazobactam, which is applied to the active ingredients of heterocyclic compounds, antibacterial drugs, pharmaceutical formulations, etc., can solve problems such as poor clarity, incomplete dissolution, and static electricity, and achieve good solubility, The effect of fast dissolution
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Embodiment 1
[0034] Example 1 Screening of Cefuroxime Sodium and Tazobactam Sodium with Different Particle Sizes
[0035] Take 1000 g of cefuroxime sodium and pass through 65 mesh sieve, 80 mesh sieve, 100 mesh sieve, 120 mesh sieve, 140 mesh sieve and 150 mesh sieve in sequence, respectively take the part that can pass through 65 mesh sieve and cannot pass through 80 mesh sieve (i.e. The powder within the particle size range of 180 μm to 250 μm is called “Fuxin A”), and the part that can pass through the 80 mesh sieve and cannot pass through the 100 mesh sieve (that is, the powder within the particle size range of 150 μm to 180 μm is called “Fuxin B” ), which can pass through a 100-mesh sieve and cannot pass through a 120-mesh sieve (that is, the powder within the particle size range of 125 μm to 150 μm is called “Fuxin C”), and can pass through a 120-mesh sieve and cannot pass through a 140-mesh sieve (that is, 106 μm The powder within the particle size range of 90 μm to 125 μm is called...
Embodiment 2
[0038] Embodiment 2 cefuroxime sodium and tazobactam sodium pharmaceutical composition
[0039] Tazobactam ("Bactan D" and "Bactam E") with different particle sizes screened in Example 1, and tazobactam with different particle sizes ("Fuxin A", "Fuxin B", "Fuxin C", "Fuxin D", "Fuxin E" and "Fuxin F"), respectively accurately weigh 0.66 g of each cefuroxime sodium and 0.33 g of each tazobactam sodium (weight ratio 2: 1), respectively packed in 10mL antibiotic glass, add 7mL distilled water, observe the dissolution effect and measure the dissolution time, the results are as follows:
[0040]
[0041] Note: In the above table, " / " in the dissolution phenomenon column means no sticking to the wall and small lumps.
[0042] From the results in the above table, it can be found that when “Bactan D” and “Bactan E” are repacked with cefuroxime sodium of different particle sizes, due to poor fluidity, it is difficult to repackage and it is difficult to ensure that the products are ...
Embodiment 3
[0043] Example 3 Pharmaceutical composition of cefuroxime sodium and tazobactam sodium
[0044] According to the experimental results of Example 1, "Bactan A", "Bactan B" and "Bactan C" were further selected and cefuroxime sodium with different particle sizes were subpackaged, and the subpackaging conditions were observed and the dissolution effect was determined. Tazobactam sodium ("Bactan A", "Bactan B" and "Bactam C") with different particle diameters screened in Example 1, and cefuroxime sodium with different particle diameters ("Fuxin A" , "Fuxin B", "Fuxin C", "Fuxin D", "Fuxin E" and "Fuxin F"), respectively accurately weigh 0.66g of cefuroxime sodium with each particle size and other Zobactam sodium 0.33g (weight ratio 2:1), cefuroxime sodium 0.75g of each particle size and tazobactam sodium 0.25g (weight ratio 3:1), cefuroxime sodium of each particle size 0.8 g and each particle size tazobactam sodium 0.2g (weight ratio 4:1), each particle size cefuroxime sodium 0.88...
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