Sitafloxacin tablet and preparation method thereof
A technology of sitafloxacin and tablets, which is applied in the field of pharmacy, can solve problems such as unsatisfactory release rate of sitafloxacin tablets, increase of production cost and operation difficulty, instability of sitafloxacin to light, etc., to avoid Release unqualified, improve bioavailability, avoid photo-instability effects
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Embodiment 1
[0029] Embodiment 1 sitafloxacin tablet
[0030] Prescription 1:
[0031] (1) Pill core prescription:
[0032] Names of raw materials and auxiliary materials
Dosage
Sitafloxacin hydrochloride
50g (calculated as sitafloxacin)
sucrose
35g
Sodium carboxymethyl starch
5g
Povidone
10g
20% ethanol solution
100g
Make 1000 capsules
[0033] (2) Tablet core prescription
[0034] material name
Dosage
microcrystalline cellulose
250g
lactose
150g
Made into 1000 pieces
[0035] Preparation Process
[0036] (1) Preparation of sitafloxacin pellets: Weigh the prescribed amount of sitafloxacin main drug and auxiliary materials and mix them uniformly according to the principle of equal increase, add the prescribed amount of 20% ethanol solution, stir well and put into double Screw extruder, the orifice diameter is 0.4-0.5mm; the extruded strip-shaped m...
Embodiment 2
[0038] Embodiment 2 sitafloxacin tablet
[0039] Prescription 2:
[0040] (1) Pill core prescription:
[0041] Names of raw materials and auxiliary materials
Dosage
Sitafloxacin anhydrous
50g (calculated as sitafloxacin)
lactose
35g
Croscarmellose Sodium
5g
Povidone
10g
30% ethanol solution
100g
Make 1000 capsules
[0042] (2) Tablet core prescription
[0043] material name
Dosage
microcrystalline cellulose
500g
Made into 1000 pieces
[0044] Preparation Process
[0045](1) Preparation of sitafloxacin pellets: Weigh the prescribed amount of sitafloxacin main drug and auxiliary materials and mix evenly according to the principle of equal increase, add the prescribed amount of 30% ethanol solution, stir well and put into double Screw extruder, the orifice diameter is 0.4-0.5mm; the extruded strip-shaped material is collected in the spheronizer, an...
Embodiment 3
[0047] Embodiment 3 sitafloxacin tablet
[0048] Prescription 3:
[0049] (1) Pill core prescription:
[0050] Names of raw materials and auxiliary materials
Dosage
Sitafloxacin anhydrous
50g (calculated as sitafloxacin)
Mannitol
35g
Sodium carboxymethyl starch
5g
Hypromellose
10g
25% ethanol solution
100g
Make 1000 capsules
[0051] (2) Tablet core prescription
[0052] material name
Dosage
microcrystalline cellulose
350g
lactose
100g
Made into 1000 pieces
[0053] Preparation Process
[0054] (1) Preparation of sitafloxacin pellets: Weigh the prescribed amount of sitafloxacin main drug and auxiliary materials and mix them uniformly according to the principle of equal increase, add the prescribed amount of 25% ethanol solution, stir well and put into double Screw extruder, the orifice diameter is 0.4-0.5mm; the extruded strip-shaped ...
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