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Paracetamol and caffeine dry suspension and preparation method thereof

A technology of dry suspension and suspending agent, which is applied in anti-inflammatory agents, pharmaceutical formulas, non-central analgesics, etc. It can solve the problems of poor water solubility and low bioavailability of phenolic coffee, and achieve excellent drug efficacy and biological High utilization and fast absorption effect

Active Publication Date: 2013-06-05
CP PHARMA QINGDAO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the shortcomings of existing phenolic coffee with poor water solubility and low bioavailability, the present invention has invented phenolic coffee dry suspension

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The preparation of embodiment 1 phenol coffee dry suspension

[0032] Active ingredient (the ratio of acetaminophen and caffeine is 1:0.13) 50g

[0033] Mannitol 700g

[0034] Aspartame 50g

[0035] Methylcellulose: dextran (4:1 by weight) 50g

[0036] Anhydrous disodium hydrogen phosphate 10g

[0037] The preparation method is as follows:

[0038] (1) Precisely weigh the active ingredients of the prescription amount and pass through an 80 mesh sieve;

[0039] (2) Precisely weigh mannitol, aspartame, methylcellulose, dextran, and anhydrous disodium hydrogen phosphate respectively, pass through an 80-mesh sieve, and mix uniformly in equal increments;

[0040] (3) Steps (1) and (2) are mixed in equal increments to obtain a mixed powder, and passed through a 40-mesh sieve;

[0041] (4) After passing the intermediate inspection, the finished product can be obtained by sub-packaging.

Embodiment 2

[0042] The preparation of embodiment 2 phenol coffee dry suspension

[0043] Active ingredient (the ratio of acetaminophen and caffeine is 1:0.13) 50g

[0044] Mannitol 700g

[0045] Aspartame 50g

[0046] Methylcellulose: dextran (1:1 by weight) 50g

[0047] Anhydrous disodium hydrogen phosphate 10g

[0048] The preparation method is the same as in Example 1.

Embodiment 3

[0049] The preparation of embodiment 3 phenol coffee dry suspension

[0050] Active ingredient (the ratio of acetaminophen and caffeine is 1:0.13) 50g

[0051] Mannitol 700g

[0052] Aspartame 50g

[0053] Methylcellulose: dextran (3:1 by weight) 50g

[0054] Anhydrous disodium hydrogen phosphate 10g

[0055] The preparation method is the same as in Example 1.

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PUM

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Abstract

The invention discloses a paracetamol and caffeine dry suspension and a preparation method of the paracetamol and caffeine dry suspension. The paracetamol and caffeine dry suspension comprises 40-100 parts of active ingredients, 600-2200 parts of filler, 50-200 parts of flavoring agents, 40-100 parts of suspending agents and 10-40 parts of flocculating agents, wherein the active ingredients are formed by acetaminophen and caffeine. The ratio of the acetaminophen to the caffeine is 1:0.13 by weight. The paracetamol and caffeine dry suspension is even in particle distribution, good in stability, large in distribution area in a stomach and intestines, quick in absorption, high in bioavailability, quick in effect producing, and superior to paracetamol and caffeine premixing agents in pharmaceutical effect.

Description

technical field [0001] The invention relates to a dry suspension, in particular to a phenolic coffee dry suspension and a preparation method thereof, belonging to the field of phenolic coffee preparations. Background technique [0002] Dry suspensions refer to insoluble drugs and suitable excipients made into powders or granules, which can be dispersed into suspensions for oral administration by adding water and shaking before use. The dry suspension belongs to the suspension. After adding water to disperse, it should meet the quality requirements of the suspension. The particles in the suspension should be uniformly dispersed and should not be weighed quickly. It should be quickly redispersed. In addition to the effectiveness and chemical stability of the ideal suspension (mainly depends on the nature of the main drug), the ideal suspension should also (1) settle slowly, and can be redispersed by shaking gently after settling; The size should remain unchanged in long-term...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/522A61K31/167A61K47/38A61K47/36A61K9/14A61P29/00A61P25/04A61P25/06
Inventor 王明刚陈阳生任莉
Owner CP PHARMA QINGDAO CO LTD
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