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Uses of statin compound serving as partly used medicine for curing diabetes mellitus

A compound, diabetes technology, applied in the field of medicine to achieve the effects of enhancing adherence and convenience, promoting secretion, and increasing serum insulin levels

Active Publication Date: 2013-06-05
PEKING UNIV THIRD HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] But without exception, the conclusions drawn from the above reports are all based on oral statins

Method used

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  • Uses of statin compound serving as partly used medicine for curing diabetes mellitus
  • Uses of statin compound serving as partly used medicine for curing diabetes mellitus
  • Uses of statin compound serving as partly used medicine for curing diabetes mellitus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Preparation of simvastatin topical injection

[0057] Dissolve 1000 mg of simvastatin in 10 ml of PBS phosphate buffer (purchased from Beijing Zhongshan Jinqiao Biotechnology Co., Ltd.), containing 2% dimethylsulfoxide (DimethylSulfoxide, DMSO, purchased from Sigma Company) and 0.1% Bovine Serum Albumin (Bovine SerumAlbumin, BSA, purchased from Sigma Company) was obtained by homogenizing the obtained solution.

Embodiment 2

[0059] Preparation of pravastatin topical injection

[0060] Suspend 1000 mg of pravastatin sodium in 10 ml of fat emulsion (Intralipid), and homogenize the obtained solution.

Embodiment 3

[0062] Fluvastatin topical injection preparation

[0063] Dissolve 1000 mg of fluvastatin sodium in 10 ml of physiological saline containing 3% paloxamer 188 (BSF, Germany), and homogenize the obtained solution.

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Abstract

The invention relates to uses of a statin compound serving as part-used medicine for curing diabetes mellitus, and particularly discloses statins which are partly used on skeleton so as to promote insulin secretion and enhance insulin sensitivity and used for curing the diabetes mellitus. In addition, the invention further provides partly used composition of the statin compound for curing the diabetes mellitus.

Description

technical field [0001] The invention relates to the technical field of medicine, more specifically, relates to the new application of HMG-CoA reductase inhibitor (statin compound) for local treatment of diabetes, and the local composition thereof. Background technique [0002] The incidence of diabetes in the world is increasing year by year, and it has become the third chronic disease that seriously endangers human health after tumors and cardiovascular and cerebrovascular diseases in the world. In recent years, the incidence of diabetes has been increasing, and the number of patients has increased sharply. According to statistics, the prevalence rate among Chinese adults over the age of 20 reaches 9.7%, and the number of patients is close to 100 million. The multi-system complications caused by diabetes have a high mortality rate and high disability rate, seriously endangering social health, and the resulting high medical expenses have brought a heavy burden to the countr...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61P3/10
Inventor 宋纯理杨宁崔岳毅徐迎胜
Owner PEKING UNIV THIRD HOSPITAL
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