A kind of metoprolol hydrochlorothiazide succinate sustained-release pellet capsule and preparation method thereof
A technology of metoprolol succinate and toprolol hydrochlorothiazide, which is applied in the field of metoprolol succinate hydrochlorothiazide sustained-release pellet capsules and its preparation, can solve the problem of the absence of metoprolol succinate hydrochlorothiazide sustained-release pellet preparations Production and marketing and registration declaration, difficult promotion of production technology, and sudden release of preparations, etc., to achieve the effects of small differences in individual bioavailability, continuous and stable antihypertensive effect, and uniform absorption speed
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Embodiment 1
[0041] 1. Preparation of metoprolol succinate sustained-release pellets:
[0042] prescription:
[0043]
[0044] Preparation process: Mix metoprolol succinate and microcrystalline cellulose evenly, and make powder for later use. Dissolve PVP K30 in purified water, add the above mixed powder to make a soft material, use the extrusion spheronization method to make the core of the pill, dry, sieve and take the core of the pill of 20-30 mesh, and use it for coating. Prepare Eudrag it NE30D, talcum powder and titanium dioxide with purified water to prepare a slow-release coating solution with a solid content of 20%, dissolve and stir to make it fully dispersed. Put the core of the pellet containing the drug in a fluidized bed, adjust the process parameters to ensure the fluidized state, spray the slow-release coating solution on the surface of the core of the pellet containing the drug, take out the pellet and put it in an oven at 40°C for 24 hours to prepare the succinate To...
Embodiment 2
[0051] 1. Preparation of metoprolol succinate sustained-release pellets:
[0052] prescription:
[0053]
[0054] Preparation process: Dissolve metoprolol succinate and PVP K30 in ethanol, place the blank pellet core in a fluidized bed, adjust the process parameters to ensure the fluidized state, spray the above drug-containing solution on the surface of the pellet core, and dry , and sifted to select 20-30 mesh pill cores containing medicine. Ethyl cellulose, talcum powder and titanium dioxide are prepared with ethanol into a slow-release coating solution with a solid content of 10%, dissolved and stirred to make them fully dispersed. Put the core of the pellet containing the drug in a fluidized bed, adjust the process parameters to ensure the fluidized state, spray the slow-release coating solution on the surface of the core of the pellet containing the drug, take out the pellet and put it in an oven at 50 ° C for 10 hours to prepare the succinate Torol extended-release...
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