Patents
Literature
Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
Hiro

37results about How to "Achieve toxic side effects" patented technology

Metroprolol succinate hydrochlorothiazide sustained-release pellet capsule and preparation method thereof

InactiveCN103142618AUniform absorption rateSmall differences in individual bioavailabilityOrganic active ingredientsPharmaceutical delivery mechanismSustained release pelletsSide effect
The invention discloses a metroprolol succinate hydrochlorothiazide sustained-release pellet capsule and a preparation method thereof. The metroprolol succinate hydrochlorothiazide sustained-release pellet capsule is prepared by mixing a metroprolol succinate sustained-release pellet and a hydrochlorothiazide quick-release pellet according to provided dose ratio, and filling into a hard capsule. The metroprolol succinate sustained-release pellet constantly releases the medicine for 24 hours, and the medicine is taken once a day, thereby retaining the lasting antihypertensive effect; the hydrochlorothiazide quick-release pellet is rapidly absorbed so as to achieve the diuresis and antihypertensive effect, and by combining the pellets, the antihypertensive effect is doubled, the toxic and side effects of the medicine are reduced, the number of the medicine administrations is reduced, and lasting and stable antihypertensive effects are achieved in vivo, so that the compliance of patients is improved; and meanwhile as the sustained-release pellet preparation is composed of hundreds of pellets of uniform granule sizes, the sudden release of the whole preparation is not caused by the breakage of individual pellets, so that the medicine is safer than a sustained-release tablet, smaller in irritation to gastrointestinal tracts and more stable in blood concentration, and the clinical effectiveness and security are effectively improved.
Owner:广州科的信医药技术有限公司

Medicine for treating functional constipations

InactiveCN104587401ASolve the distress that requires long-term medicationTo achieve the purpose of treating constipationDigestive systemPlant ingredientsTherapeutic effectOfficinalis
The invention discloses a medicine for treating functional constipations, belongs to the technical field of traditional Chinese medicines, and aims at overcoming the problems that the medicine in the prior art is poor in treatment effect on functional constipations and the functional constipations cannot be cured once and for all. The medicine is prepared from the following raw materials in parts by weight: 10 parts of tatarian aster root, 10 parts of rhubarb stir-fried with wine, 30 parts of bunge cherry seed, 10 parts of immature bitter orange, 30 parts of dandelion, 10 parts of mangnolia officinalis, 10 parts of toasted almond, 30 parts of fried semen raphani, 10 parts of fried zedoary, 30 parts of polygonum multiflorum, 6 parts of cimicifugae foetidae, 10 parts of radix polygonati officinalis, 40 parts of cynomorium songaricum, 30 parts of semen cassia, 10 parts of areca-nut, 10 parts of rhizoma pinellinae praeparata, 10 parts of agilawood, 15 parts of polygonatum kingianum, 15 parts of dendrobium, 15 parts of radix ophiopogonis, 10 parts of fructus perillae, 15 parts of sinapis alba, 10 parts of herba epimedii and 10 parts of fingered citron. The medicine for treating various functional constipations is fast in acting, short in treatment course and accurate in curative effect; the recovery rate can be up to 95.5%; and the effective rate is 99.5%.
Owner:庄肃娟

Aloe mask

The present invention relates to a mask, particularly to an aloe mask, which is characterized in that the aloe mask is prepared from the following raw materials by weight: 15-35 parts of aloe, 1-3 parts of fibroin peptide, 3-5 parts of zinc oxide, 7-9 parts of polyethylene glycol, 5-7 parts of hyaluronic acid, 2-4 parts of olive oil, 3-5 parts of fruit acid, 8-10 parts of typhonium giganteum engl, 10-20 parts of smilax china, 10-20 parts of salvia miltiorrhiza, 5-7 parts of balsam pear root, 10-20 parts of deionized water, and 8-10 parts of honey. According to the aloe mask of the present invention, the aloe is adopted as the raw material, the added and used traditional Chinese medicines are the natural plants and have characteristics of no additive, no chemical ingredient, no dependence and no toxic-side effect, and the aloe is rich in vitamins, proteins, iron, calcium, potassium, phosphorus, magnesium, zinc and other minerals, glutamic acid, arginine, fructose and the like, is easily absorbed by the skin, and has effects of immunity regulating, skin beautifying and whitening, skin moisturizing, spot removing, toxin expelling, and face nourishing.
Owner:霍兆健

Anti-crystallization suspending agent capable of being rapidly uniform and stable

The invention relates to the field of fertilizer auxiliary materials and provides an anti-crystallization suspending agent capable of being rapidly uniform and stable. The anti-crystallization suspending agent is used in high-concentration liquid water-soluble fertilizer. An effective component is prepared from the following raw materials in percentage by weight: 3.5 percent of sodium alginate, 1.5 percent of xanthan gum, 20 to 30 percent of glycerol and 65 to 75 percent of polyethylene glycol. The anti-crystallization suspending agent can rapidly absorb water to be expanded, and an original immersing and grinding process, which needs more than ten hours, is shortened; the anti-crystallization suspending agent can be instantly expanded to expected viscosity and the state of a product is uniform and stable. The suspending agent can realize the effects of increasing the viscosity of liquid to reach a suspending effect and also can realize an anti-crystallization effect in certain high-concentration systems. The raw materials adopted by the formula have no toxin and no harms and the formula has wide application. The utilization ratio of the product is 1 to 50; the adopted raw materials have no toxic side effect on crops.
Owner:SHENGTAI BIOENG CO LTD OF JILIN WANTONG PHARMACY GRP CO

Environment-friendly energy-saving totally-degradable disposable injector and preparation method thereof

The invention provides an environment-friendly energy-saving totally-degradable disposable injector and a preparation method thereof. All the parts of the disposable injector are formed by use of a single degradable polylactic acid substrate with molecular weight of 2 million. The injection molding process of the disposable injector comprises the following steps: setting the temperature of a feeding hole within the range of 150-165 DEG C, the temperature of a compression section within the range of 155-170 DEG C, the temperature of a metering section within the range of 160-175 DEG C and the temperature of a nozzle within the range of 150-180 DEG C, setting the temperature of a mold within the range of 10-40 DEG C, injecting under the pressure within the range of 50-85Mpa for 4-5 seconds, maintaining pressure for 0 second, and keeping the rotating speed of a screw within the range of 160-180r / min; the various indices of the obtained totally-degradable disposable injector completely conform to the requirements of the national standards of GB15810-2001 sterile hypodermic syringes for single use and the national industrial standards of YY0497-2005 sterile insulin syringe for single use; after being abandoned, the injectors can be degraded by microorganisms into H2O and CO2 under natural conditions without being burnt; the environment is not polluted, and the purposes of controlling pollution, reducing white pollution, protecting the environment and saving the energy are achieved.
Owner:SHANGHAI LINJING MEDICAL EQUIP

Externally applied ointment with effect of treating osteoarticular pain and preparation method thereof

The invention relates to externally applied ointment with an effect of treating osteoarticular pain and a preparation method thereof. The ointment is prepared from the following raw materials in partsby weight: 5-10 parts of arnica, 8-15 parts of luffa seeds, 5-10 parts of siegesbeckia herbs, 15-25 parts of gastrodia tuers, 6-12 parts of cactus, 8-15 parts of goat bones, 15-20 parts of castor beans, 4-8 parts of lumbrukinase, 10-20 parts of pubescent angelica roots, 5-10 parts of garden balsam stems, 8-15 parts of Chinese taxillus twigs, 15-20 parts of wormwoods, 8-15 parts of tuber fleeceflower stems, 20-30 parts of corydalis tubers, 25-30 parts of rhododendron dauricum, 10-15 parts of peganum harmala, 4-8 parts of hirudin, 4-8 parts of rosemary, 10-15 parts of rhizoma cibotii, 10-15 parts of zedoary, 8-15 parts of pepper, 15-25 parts of aralia elata, 8-15 parts of pangolin scales, 15-20 parts of common clubmoss herbs, 15-20 parts of fructus evodiae, 8-15 parts of common selfheal fruit-spikes, 10-15 parts of earthworms, 8-12 parts of borneol, 12-15 parts of processed frankincense and 12-15 parts of processed myrrh. The externally applied ointment for treating osteoarticular painhas a good treatment effect, and the medicine can directly reaches a focus by applying with an application device to achieve good curative effect, high cure rate and small side effect.
Owner:王浙斌

Dual-response amphiphilic polyphosphazene targeted drug carrier material and preparation method thereof

The invention provides a dual-response amphiphilic polyphosphazene targeted drug carrier polymer material. The dual-response amphiphilic polyphosphazene targeted drug carrier polymer material is grafted with a hydrophilic chain segment MPEG (Methoxy Polyethylene Glycol) and an enzyme-sensitive hydrophobic chain segment peptide chain, an acid-sensitive drug is bonded on a hydrophobic side chain, micelles can be easily formed in water through self-assembly, the micelles can be intravenously injected into a human body, can accumulate in a tumor site through an EPR (Enhanced Permeability and Retention) effect and can go into cells, the acidity of a physiological environment in tumor cells is stronger, the pH (Potential of Hydrogen) value is about 4.5 to 5.5, but the normal physiological pH value of the human body is 7.4; the cells contain a large amount of lysosomal enzyme, a micelle structure of a drug carrier polymer can be dissociated under dual functions of low pH and the lysosomal enzyme, free adriamycin can be released, and the adriamycin acts on DNA (Deoxyribonucleic Acid) to stop copying of the DNA, so that the tumor cell death is caused, and the purposes of targeted therapy and no toxic and side effects are finally achieved.
Owner:YANBIAN UNIV

Lemon flower, leaf and fruit health-care tablets and preparation method thereof

The invention discloses lemon flower, leaf and fruit health-care tablets and a preparation method thereof. The preparation method comprises the following steps of picking lemon flowers and lemon leaves, cleaning the picked lemon flowers and the picked lemon leaves, and drying the cleaned lemon flowers and the cleaned lemon leaves; enabling young lemon fruits to be frozen and dried, crushing the frozen and dried young lemon fruits, and adding water for stirring so as to perform pelleting; and then performing microwave sterilization, adding magnesium stearate for tabletting and shaping, and then performing microwave treatment so as to obtain the lemon flower, leaf and fruit health-care tablets. According to the lemon flower, leaf and fruit health-care tablets and the preparation method thereof disclosed by the invention, the lemon flowers, the lemon leaves and the lemon fruits are made into lemon health-care tablets which are convenient to carry, and waste raw materials are comprehensively used, so that the nutrient components are maintained to the maximum extent, and the mouth feel of lemons is improved; the lemon flower, leaf and fruit health-care tablets are convenient to eat, and suitable for both old and young, and can effectively improve the sub-health groups suffering from high blood lipid and high blood pressure. According to the lemon health-care tablets, any other substances are not added, so that the product security and the product health are guaranteed. The lemon flower, leaf and fruit health-care tablets provided by the invention have the functions of resisting oxidation, resisting funguses, reducing blood lipid, reducing blood pressure and the like. Clinical tests show that after being eaten for a long term, the lemon flower, leaf and fruit health-care tablets can strengthen the immunity of organisms, and can achieve the effect that diseases do not relapse. The lemon flower, leaf and fruit health-care tablets are safe to eat, free from toxic or side effects and notable in treatment effect.
Owner:INST OF TROPICAL & SUBTROPICAL CASH CROP YUNNAN ACAD OF AGRI SCI

Castration liquid for poultry and preparation method thereof

The invention belongs to the field of pharmacy, and in particular relates to a castration liquid for poultry and a preparation method thereof. The present invention can not only effectively sterilize poultry by adding ethinyl estradiol, nicotine, nonylphenol and coriander extract into the castration liquid, but also achieve the effect of improving the quality of poultry meat, increasing the nutritional level, and having no toxic and side effects on poultry. By using the present invention, the testis begins to shrink after 9 days, and the ideal castration effect can be achieved after 15 days. Aiming at the problem of easy infection of poultry after castration, the present invention adds formaldehyde, calcium propionate and sodium lactate to the castration solution, through the synergistic effect of the three, not only achieves the effect of disinfection and antisepsis, but also plays an anti-inflammatory effect on inflammation caused by local injection . The material of the invention is cheap, greatly reduces the production cost, promotes the development of the aquaculture industry, improves the profit of the aquaculture industry, reduces the labor intensity of the aquaculture personnel in the aquaculture farm, and has obvious economic and social benefits and popularization and application value.
Owner:HENAN UNIV OF SCI & TECH

A kind of metoprolol hydrochlorothiazide succinate sustained-release pellet capsule and preparation method thereof

The invention discloses a slow-release pellet preparation containing metoprolol succinate and hydrochlorothiazide and a preparation method thereof. The slow-release pellets of metoprolol succinate and the quick-release pellets of hydrochlorothiazide are mixed according to a prescribed dosage ratio and then filled. Made in hard capsules. Metoprolol succinate sustained-release pellets release continuously for 24 hours and take once a day to maintain a lasting antihypertensive effect. Hydrochlorothiazide immediate-release pellets are quickly absorbed to achieve diuretic and antihypertensive effects. The combination of the two makes the antihypertensive effect effective The additive effect can reduce the toxic and side effects of the drug, reduce the number of times of taking the drug, achieve a sustained and stable antihypertensive effect in the body, and improve the patient's compliance. At the same time, the sustained-release pellet preparation is composed of thousands of pellets with uniform particle size , the breakage of individual pellets will not lead to the sudden release of the entire preparation, which is safer than sustained-release tablets, less irritating to the gastrointestinal tract, and more stable blood drug concentration, effectively improving clinical effectiveness and safety.
Owner:广州科的信医药技术有限公司

Traditional Chinese medicine composition for treating arthritis and synovitis and preparation method thereof

The invention discloses a traditional Chinese medicine composition for treating arthritis and synovitis and a preparation method thereof. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 25-30 parts of safflower, 25-30 parts of fried eucommia ulmoides, 25-30 parts of angelica sinensis, 25-30 parts of radix cyathulae, 15-20 parts of salvia miltiorrhiza, 15-20 parts of cassia twig, 15-20 parts of pawpaw, 25-30 parts of radix aconiti preparata, 25-30 parts of radix aconiti kusnezoffii preparata, 25-30 parts of turmeric, 25-30 parts of ephedra,180-220 parts of semen brassicae, 10-15 parts of eupolyphaga, 18-22 parts of earthworms, 18-22 parts of zaocys dhumnade, 13-17 parts of buthus martensi karsch, 18-22 parts of moxa, 13-17 parts of carbonized sanguisorba roots, 10-15 parts of ligusticum wallichii, 13-17 parts of asarum, 10-15 parts of radix clematidis, 13-17 parts of panax notoginseng, and 10-15 parts of rhizoma et radix notopterygii. According to a traditional Chinese medicine syndrome differentiation theory, syndrome differentiation treatment and warm-heat clearing and nourishing are conducted, the formula is scientific, reasonable and unique, the treatment effect is remarkable and reliable, medicine properties are mild, toxic and side effects are avoided, and various side effects and dependence caused by long-term use ofwestern medicine for treating diseases can be avoided.
Owner:李秋润

Beauty-maintaining and spot-removing traditional Chinese medicine composition and preparation method thereof

The invention relates to a beauty-maintaining and spot-removing traditional Chinese medicine composition. Each dose of the traditional Chinese medicine composition is prepared from the following bulk drugs by weight: 25 to 35 g of peach blossom, 28 to 32 g of globe amaranth, 13 to 17 g of stigma croci, 18 to 22 g of tendril-leaved fritillary bulb, 18 to 22 g of dahurian angelica root, 19 to 21 g of poplar peel, 28 to 32 g of pearl powder, 18 to 20 g of persimmon frost, 18 to 22 g of Siberian elm bark and 28 to 32 g of white nephrite. According to the invention, the traditional Chinese medicine composition is developed through careful choosing and repeated comparison of more than one hundred of pure traditional Chinese medicines and specific syndrome differentiation on the basis of the pattern of clinical syndrome; the composition has strong targeting performance, can realize rapid conditioning, does not contain hormone and western medicine, and incurs no irritation, redness, decortication and the like of the skin after usage; the composition can rapidly infiltrate into the skin to realize quickening of blood, dispelling of blood stasis, improvement of local microcirculation, activation of epidermic cells, dredging of obstruction and elimination of toxin, thereby achieving spot-removing effect; and the composition has the advantages of a reasonable formula, composition of pure traditional Chinese medicines, no hormone, no side effects and irritation, good treatment effect, cheap price and capacity of realizing simultaneous treatment of principal and subordinate symptoms.
Owner:赵德欣

Traditional Chinese medicine for treating halitosis and preparation method thereof

The invention provides traditional Chinese medicine for treating halitosis and a preparation method thereof, and relates to the technical field of medicine for treating halitosis. The traditional Chinese medicine is used for solving the problems of large side effects and incomplete treatment of the existing medicine for treating halitosis. The traditional Chinese medicine for treating halitosis is a pill and is composed of the following components in parts by weight: 40-80 parts of licorice, 20-40 parts of safflower, 100-140 parts of ligusticum wallichii, 160-200 parts of clove, 280-320 parts of radix angelicae, 40-80 parts of jujube, 100-140 parts of coix lachryma-jobi kernel and 100-200 parts of honey. The traditional Chinese medicine is prepared by grinding, mixing, pelleting and sterilizing procedures. The traditional Chinese medicine pill is good in raw material compatibility, remarkable in curative effect, quick to become effective, free of recurrence after cure, free of any toxic side effect, convenient to carry, convenient to take, simple to prepare, cheap and easy to obtain raw materials and is easy to achieve industrialization, and the traditional Chinese medicine is used for systematically regulating from interior of human body to treat both symptoms and root causes.
Owner:QINGDAO MUNICIPAL HOSPITAL
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products