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Purification method of lysine

A purification method and technology of lysine, applied in the field of lysine purification, can solve the problems of low purity of lysine solution and low crystallization yield

Inactive Publication Date: 2013-06-12
COFCO BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the shortcomings of low purity and low crystallization yield of lysine solution obtained in the prior art, and provide a method for purifying lysine that can improve the purity of lysine solution and crystallization yield

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] This example is used to illustrate the purification method of lysine provided by the present invention.

[0034] (1) Take a lysine solution with a content of 65% by weight (purity: 96% by weight), and use concentrated hydrochloric acid with a concentration of 36% by weight to adjust the pH value of the lysine solution to 9.7.

[0035] (2) Introduce the above-mentioned lysine solution after pH adjustment into the ion exchange resin equipment (column volume is 400mL, filled with 280g exchange resin), and strongly basic anion exchange resin with model D201 (Su Qing brand) Contact, the contact conditions are as follows: the contact temperature is 60°C, the flow rate of the lysine solution introduced is 2-3 volume columns / hour, and the weight ratio of the introduced lysine solution to the exchange resin is 8:1. Collect the lysine-containing effluent from the lower end of the ion exchange column.

[0036] (3) After the lysine solution is in contact with the ion resin, the an...

Embodiment 2

[0043] This example is used to illustrate the purification method of lysine provided by the present invention.

[0044] Purify and crystallize the lysine solution according to the same method as in Example 1. The difference is that in step (1), take a lysine solution with a content of 70% by weight (purity: 96% by weight), and use concentrated hydrochloric acid to adjust the lysine solution. The pH of the lysine solution was brought to 9. The purity of lysine in the finally obtained lysine effluent was 98.36% by weight, and the purity was increased by 2.36%; the yield of crystallization was 66% by weight.

Embodiment 3

[0046] This example is used to illustrate the purification method of lysine provided by the present invention.

[0047] Purify and crystallize the lysine solution according to the same method as in Example 1. The difference is that in step (1), take a lysine solution with a content of 60% by weight (purity: 96% by weight), and use concentrated hydrochloric acid to adjust the lysine solution. The pH of the lysine solution was brought to 8. The purity of lysine in the finally obtained lysine effluent was 97.9% by weight, and the purity was increased by 1.9%; the yield of crystallization was 65.8% by weight.

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PUM

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Abstract

The invention provides a purification method of lysine, wherein the method comprises the following steps of: adjusting the pH value of a lysine solution with the lysine content of 20-70wt% from larger than 6 to smaller than or equal to 9.7, and enabling the pH value adjusted lysine solution to be in contact with anion exchange resin to realize ion exchange to obtain a lysine-contained effluent; or enabling the lysine solution to be in contact with cation exchange resin to realize ion exchange, and eluting the lysine absorbed on the cation exchange resin to obtain the lysine-contained effluent. Due to the adoption of the technical scheme, the purity and the crystallization yield of the purified lysine solution are increased.

Description

technical field [0001] The invention relates to a method for purifying lysine. Background technique [0002] Lysine is one of more than 20 kinds of amino acids. It is indispensable for humans and animals and is one of the eight essential amino acids that cannot be synthesized by humans. It is the main component of protein. The continuous improvement of people's quality of life and the change of food structure have accelerated the total consumption demand of lysine. Now lysine has become an important raw material in food, medicine, feed industry and cosmetics and other industries. [0003] At present, the method of ion exchange is widely used to separate and purify lysine. This method includes first adjusting the pH value of the lysine fermentation liquid to 3 to 6, and then filtering the lysine fermentation liquid through a metal membrane or a ceramic membrane to obtain lysine. Lysine membrane filtrate (or flocculation and filtration of lysine fermentation liquid to obtain ...

Claims

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Application Information

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IPC IPC(8): C07C229/26C07C227/40
Inventor 满云卢宗梅陈影徐丽红
Owner COFCO BIOTECHNOLOGY CO LTD
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