Compositions comprising acidic extracts of mastic gum

A composition, the technology of frankincense, applied in the direction of drug combination, active ingredients of anhydride/acid/halide, medical preparations containing active ingredients, etc., to achieve the effect of promoting wound healing and prolonging life

Active Publication Date: 2013-06-19
REGENERA PHARMA LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] However, there remains an unmet need for safe, versatile and effective agents for the treatment of a variety of disorders, such as those associated with neurological deficits and related neurodegenerative disorders, including, for example, Alzheimer's disease, stroke and similar conditions, and other conditions such as tissue regeneration, wound and tissue repair

Method used

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  • Compositions comprising acidic extracts of mastic gum
  • Compositions comprising acidic extracts of mastic gum
  • Compositions comprising acidic extracts of mastic gum

Examples

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preparation example Construction

[0231] Commercial preparations of mastic are available, for example, from Chios Gum Mastic Growers Association or G. Baldwin & Co., U.K.

[0232] Analytical methods used to determine the precise chemical composition of the isolated acidic fraction of boswellia obtained include nuclear magnetic resonance (e.g. 1 HNMR and 13 CNMR), viscometry, various mass spectrometry methods (e.g. MALDI-TOF), HPLC, combined methods such as liquid chromatography-mass spectrometry (LC-MS), UV-VIS spectrometry, IR and FT-IR spectroscopy Assays and other methods known in the art.

[0233] The method for obtaining the isolated acidic fraction of Boswellia can be as described below. By way of overview, the collected plant matter, such as frankincense, is mixed in a suitable vessel with a suitable solvent, usually a polar solvent. Suitable polar solvents include, for example, alcohols, ethers, esters, amides, aldehydes, ketones, nitriles, and combinations thereof.

[0234] Specific examples of po...

Embodiment 1

[0325] Example 1. Preparation of the Isolated Acidic Fraction of Boswellia

[0326] Boswellia (10 g) was mixed with absolute ethanol (200 ml) and the mixture was allowed to stand overnight. The mixture was shaken at 150 rpm for about 15 minutes, any larger insoluble particles were allowed to settle for 20 minutes, and the ethanol was transferred to a new flask. The residue was shaken at 200 rpm for 10 min with a fresh portion of absolute ethanol (150 ml). This ethanol fraction was mixed with the first fraction. The process was repeated with another 150 ml portion of absolute ethanol, and this fraction was mixed with the first two ethanol fractions. Subsequently, ethanol was removed in vacuo using a rotary evaporator (water bath temperature 30 °C). Hexane (300 ml) was added to the residue, and the mixture was shaken at 150 rpm for two hours. Leave overnight in a closed flask to complete dissolution of soluble material and precipitation of any insoluble material, then tran...

Embodiment 2

[0328] Example 2. Isolated Acidic Fraction (RPh-Ac) of Boswellia in USP / NF Grade Cottonseed Oil Preparation of 5% (w / w) composition

[0329] To 1 gram of the isolated acidic fraction obtained from Example 1 was added 19 grams of cottonseed oil (USP / NF) and the mixture was shaken at 150 rpm until a clear and homogeneous composition was obtained (about 2 hours).

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Abstract

The invention relates to compositions and formulations comprising isolated acidic fraction of mastic gum and uses thereof for treating impaired neurological functions as well as wound and tissue repair.

Description

field of invention [0001] The present invention relates to compositions of isolated acidic fractions from Boswellia, and uses thereof. Background of the invention [0002] The search for novel pharmaceutical entities from plants and plant products for a variety of therapeutic applications has ancient origins and continues today. One such source is mastic, also known as gum mastic or mastic gum, which is obtained as an exudate from Pistacia lentiscus L., a member of the Anacardiaceae family. obtained resin. Frankincense was used in the ancient Mediterranean world for gastrointestinal disorders such as stomach pains, indigestion and peptic ulcers. Oral administration of boswellia to human patients with duodenal ulcers and experimental rats with induced gastric and duodenal ulcers has been published to be therapeutic (Al-Habbal et al. (1984) Clin Exp Pharmacop Physio 11 (5):541-4; Said et al. (1986) J Ethnopharmacol 15(3):271-8). Although frankincense has been disclosed to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/19A61K36/00
CPCA61K31/56A61K31/569A61K36/22A61K2236/39A61K31/57A61K31/19A61P1/00A61P1/14A61P11/00A61P17/00A61P17/02A61P17/06A61P17/08A61P17/14A61P21/00A61P21/02A61P25/00A61P25/02A61P25/16A61P25/18A61P25/24A61P25/28A61P25/30A61P27/02A61P3/04A61P31/00A61P37/02A61P43/00A61P7/00A61P9/00A61P9/10C12N2501/999C12N2506/00B01D11/02
Inventor Z·哈扎安德烈·C·B·吕卡森
Owner REGENERA PHARMA LTD
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