Traditional Chinese medicine extract and preparation method thereof

A technology of extracts and natural medicines, applied in drug combinations, pharmaceutical formulas, anti-tumor drugs, etc., can solve the problems of patients with dehydration, acid-base balance imbalance, malnutrition, etc., and achieve enhanced inhibition, increased inhibition, and good synergy The effect of action

Inactive Publication Date: 2013-07-10
张宗升
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AI Technical Summary

Problems solved by technology

In recent years, with the advent and popularization of chemotherapy drugs such as 5-fluorouracil, taxanes, hydroxycamptothecin, irinotecan, Xeloda, etc., the incidence of chemotherapy-related diarrhea has increased year by year. Treatment can easily lead to dehydration, malnutrition, serum electrolyte disorder, acid-base balance disorder, etc., which not only bring great disadvantages to the recovery of the body, but also bring certain difficulties to periodic chemotherapy. Effective treatment has become an important part of the overall treatment of cancer patients
[0003]Chemotherapy-associated diarrhea, in terms of its clinical manifestations, belongs to the category of "diarrhea" in traditional Chinese medicine. The research on diarrhea in traditional Chinese medicine is remarkable, but at present There is no Chinese patent medicine that can relieve diarrhea and increase efficacy against cancer chemotherapy

Method used

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  • Traditional Chinese medicine extract and preparation method thereof
  • Traditional Chinese medicine extract and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment approach

[0030] The first step: preparation of various extracts

[0031] (1) Preparation of concentrated extract of Andrographis paniculata cinnamon

[0032] Take andrographis paniculata and cinnamon according to the compatibility ratio of 1:1 or 1-4:1, soak in 10 times the amount of distilled water for 1 hour, heat and decoct on an electric stove with asbestos net for 1 hour, filter with silk cloth, save the filtrate, and add the dregs 6 times of distilled water, soaking, decocting, and filtering in the same way, mixing the two filtrates, heating and concentrating to a small volume, filtering with an ultrafiltration membrane, and drying under reduced pressure at 70°C for 36 hours in a vacuum drying oven to obtain a brown-yellow powder.

[0033] (2) preparation of andrographolide

[0034] Weigh an appropriate amount of Andrographis paniculata powder, pre-treat with enzymatic hydrolysis, soak in ethanol, filter, and recover ethanol to obtain extract, wash with petroleum ether, remove c...

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Abstract

The invention relates to a natural pharmaceutical composition, a preparation method thereof and application thereof in preparation of toxicity reducing and efficacy enhancing drugs for cancer chemotherapy. The natural pharmaceutical composition consists of a decoction concentrated extract of andrographis paniculata (Burm.f.) Nees and cinnamomum cassia Presl, andrographolide and cinnamic aldehyde which are in the ratio of (2-8):(1-3):(4-9). The composition has an excellent treatment effect on cancer-chemotherapy-related diarrhea and can simultaneously play a synergic role in cancer chemotherapy.

Description

technical field [0001] The present invention relates to a natural medicine composition, more specifically to a natural medicine composition composed of Andrographis paniculata cinnamon decoction concentrated extract, andrographolide and cinnamaldehyde, a preparation method of the natural medicine composition and the natural medicine Use of the composition in the preparation of a medicament for reducing cancer chemotherapy-related diarrhea and synergizing cancer treatment. Background technique [0002] Malignant tumor is one of the main diseases that endanger human survival and health at present. Its treatment methods include surgery, chemotherapy, radiotherapy, and traditional Chinese medicine treatment, and the effect of chemotherapy on tumors is particularly prominent. Chemotherapy drugs, whether used alone or in combination, can cause toxic and side effects such as diarrhea in patients. Diarrhea after tumor chemotherapy is also called chemotherapy-associated diarrhea. In...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/54A61P1/12A61P35/00A61K31/365A61K31/11
Inventor 张宗升
Owner 张宗升
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