Drug and method for the prophylaxis of HIV infection and for the prophylaxis and treatment of diseases caused by or associated with HIV, including AIDS
A medicine and disease technology, applied in chemical instruments and methods, antiviral agents, pharmaceutical formulas, etc., to achieve the effect of preventing HIV infection and high curative effect
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Embodiment 1
[0140] The antiretroviral effect of the claimed agent was investigated by inhibiting HIV replication in cultures of human peripheral blood mononuclear cells infected with the HIV-1-LAI strain in vitro. The effectiveness of inhibiting HIV replication was evaluated according to the content of HIV's main nucleocapsid protein p24 in the supernatant.
[0141] The experimental research is to use affinity-purified anti-tumor necrosis factor-α rabbit polyclonal antibody, which is prepared by a professional biotechnology company. It is a very low-dose, active-enhanced form of anti-tumor necrosis The basis of the factor-α antibody aqueous solution, which is produced using homeopathic technology through the following steps: the initial matrix solution (concentration 2.5mg / ml) is heavily diluted (over-dilution) 100 12 , 100 30 , 100 50 It is equivalent to a mixture of Hundred Times Homeopathic Diluent C12, C30, C50 (hereinafter referred to as anti-TNFα ESD AB). Human peripheral blood mononuc...
Embodiment 2
[0149] The antiretroviral effect of the claimed agent was investigated by inhibiting HIV replication in cultures of human peripheral blood mononuclear cells infected with the HIV-1-LAI strain in vitro. The effectiveness of inhibiting HIV replication was evaluated according to the content of HIV's main nucleocapsid protein p24 in the supernatant.
[0150] The experimental research is to use affinity-purified anti-CD8 rabbit polyclonal antibody, which is prepared by a professional biotechnology company. It is the basis for preparing an extremely low-dose, activity-enhanced form of anti-CD8 antibody aqueous solution. The aqueous solution is produced using homeopathic technology through the following steps: the initial matrix solution (concentration 2.5 mg / ml) is heavily diluted 100 12 , 100 30 , 100 50 It is equivalent to a mixture of Hundred Times Homeopathic Diluent C12, C30, C50 (hereinafter referred to as anti-CD8 ESD AB).
[0151] Human peripheral blood mononuclear cells infected...
Embodiment 3
[0158] Using human peripheral blood mononuclear cells infected with HIV-1-LAI strain in vitro, the anti-interferon α rabbit polyclonal antibody (affinity-purified) water dilution solution of ultra-low dose (ULD), activity-enhanced form The retroviral activity was evaluated, and the water dilution was produced by the following steps: the initial matrix solution (concentration of 2.5 mg / ml) was largely diluted 100 12 , 100 30 , 100 50 It is equivalent to a mixture of Hundreds of Homeopathic Diluents C12, C30, and C50 (hereinafter referred to as anti-IFN-α ESD AB). Azidothymidine was used as a control formulation.
[0159] With the aid of Ficoll-Hypaque density gradient centrifugation, human peripheral blood mononuclear cells were separated from the blood of seronegative healthy donors. The cells were activated with 1mcg / ml phytogemmaglyutin P and 5ME / ml recombinant human interleukin-2 for 3 days.
[0160] An inoculum of 50 μl of the HIV-1-LAI strain equivalent to a dose of 100 TCID5...
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Abstract
Description
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