Diffusion pool for dynamically adjusting the effective volume
A technology of dynamic adjustment and effective volume, applied in the direction of surface/boundary effects, measuring devices, instruments, etc., can solve problems such as decreased accuracy, reduced concentration of receiving pool, loose attachment and diffusion effect, etc., to improve data accuracy and reduce Effects of Data Processing Errors
Active Publication Date: 2015-05-13
HARBIN MEDICAL UNIVERSITY
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[0002] China Patent Database (HowNet Edition) discloses "A device for transdermal diffusion test (application number: 00217044.2)", "in vitro transdermal diffusion test instrument (application number: 01207286.9)", "bubble-free diffusion cell (application number : 200920101193.4)", "Static diffusion cell for diffusion sampling system (application number: 200480008609.8)", "an experimental device for testing drug penetration through the skin (application number: 200720079932.5)", "a drug transdermal release Detection device (application number: 96228607.9)" six patents, the main device is the diffusion cell, which is a device commonly used in the static research of drugs, and its composition is composed of a supply pool, a receiving pool, a water bath device and a sampling port. The disadvantage is that the volume of the receiving pool is fixed after the experiment starts
During the experiment, if multiple sampling is required, the blank solution needs to be supplemented for sampling, which reduces the concentration of the receiving cell and causes the diffusion speed to be unstable. If the blank solution is not replenished, it will cause air bubbles in the cell or the liquid in the receiving cell is not tightly attached to the specimen. diffusion effect
Moreover, the diffusion cell error caused by the production accuracy problem in the production process
As well as the problem of cumbersome algorithm and decreased accuracy when calculating the cumulative penetration amount in the later data processing
Method used
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[0016] Relevant present invention is for reaching above-mentioned purpose of use and effect and the technical means adopted, presents preferred feasible embodiment, and cooperates as shown in the accompanying drawings, detailed description is as follows:
[0017] Such as figure 1 As shown, the diffusion cell with dynamically adjustable effective volume of the present invention mainly includes: a receiving cell 1 , a dynamic adjustment channel 2 , an adjustment piston 3 , a fine adjustment device 4 , a slide rod 5 , a fine adjustment screw 6 and a locking device 7 .
[0018] The same as the existing receiving tank, the liquid inlet of the receiving tank 1 is communicated with the supply tank 8, and the liquid taking port 9 of the receiving tank 1 is communicated with the sampling device (not shown in the figure), which is a prior art .
[0019] Different from the existing receiving tank, the receiving tank 1 of the present invention is also connected with a dynamic adjustment ...
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The invention provides a diffusion pool for dynamically adjusting the effective volume, which comprises a receiving pool, a dynamic adjusting channel, an adjusting piston and a fine adjustment apparatus. The receiving pool and the dynamic adjusting channel are communicated, and the end of the dynamic adjusting channel far from the receiving pool is connected to the fine adjustment apparatus, and the end of the adjusting piston is fixed to the fine adjustment apparatus, and the end of the adjusting piston is placed in the dynamic adjusting channel, and the fine adjustment apparatus can move the dynamic adjusting channel relative to the piston. The invention is based on a Franz diffusion pool receiving pool for increasing a dynamic adjusting apparatus, minimizing the influence of a supplement blank liquid to the receiving pool after sampling, thereby the concentration in the receiving pool is in a linear relation.
Description
technical field [0001] The invention relates to a device used in the study of drug static permeation membrane diffusion. Background technique [0002] China Patent Database (HowNet Edition) discloses "A device for transdermal diffusion test (application number: 00217044.2)", "in vitro transdermal diffusion test instrument (application number: 01207286.9)", "bubble-free diffusion cell (application number : 200920101193.4)", "Static diffusion cell for diffusion sampling system (application number: 200480008609.8)", "an experimental device for testing drug penetration through the skin (application number: 200720079932.5)", "a drug transdermal release Detection device (application number: 96228607.9)" six patents, the main device is the diffusion cell, which is a device commonly used in the static research of drugs, and its composition is composed of a supply pool, a receiving pool, a water bath device and a sampling port. The disadvantage is that the volume of the receiving po...
Claims
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IPC IPC(8): G01N13/04G01N13/00
Inventor 马燕利王永晨黄磊
Owner HARBIN MEDICAL UNIVERSITY