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PET (positron emission tomography) physiological parameter reconstruction method based on H-infinity filtering

A physiological parameter, infinite technology, applied in the field of PET images, which can solve the problems of reducing the accuracy of dynamic parameter reconstruction and the uncertainty of system response.

Active Publication Date: 2015-05-13
ZHEJIANG UNIV
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Problems solved by technology

However, the statistical characteristics of the measurement are not completely determined, and the system response also has its uncertainty, which reduces the accuracy of the reconstruction of the dynamic parameters and becomes a difficult problem for the direct reconstruction algorithm

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  • PET (positron emission tomography) physiological parameter reconstruction method based on H-infinity filtering
  • PET (positron emission tomography) physiological parameter reconstruction method based on H-infinity filtering
  • PET (positron emission tomography) physiological parameter reconstruction method based on H-infinity filtering

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Embodiment Construction

[0038] In order to describe the present invention more specifically, the technical solutions of the present invention will be described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0039] like figure 1 As shown, a reconstruction method of PET physiological parameters based on H infinite filtering includes the following steps:

[0040] (1) Collect coincidence counts.

[0041] The detectors are used to detect the biological tissues injected with radioactive substances, and the coincidence counts of n groups of PET are obtained through dynamic collection; in this embodiment, the detectors are PET scanners of the type SHR74000 produced by Hamamatsu Corporation of Japan.

[0042] The PET scanner detects the radioactive signal emitted from the human body, which is processed by the coincidence and acquisition system to form the original coincidence event. The coincidence events recorded by PET detectors include true coincidences, random ...

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Abstract

The invention discloses a PET (positron emission tomography) physiological parameter reconstruction method based on H-infinity filtering. The method includes: firstly, acquiring coincidence counting; secondly, acquiring PET blood concentration distribution data according to a blood input function; thirdly, constructing a PET state space equation; and fourthly, estimating PET physiological parameters by an H-infinity filtering algorithm. According to the method, a dynamic PET state space model is established by combining the state space theory with the PET dynamic reconstruction technology, and compartment model physiological parameters are reconstructed by the solution by H-infinity filtering. The method has the advantages that physiological parameter reconstruction and PET image reconstruction are performed in a unified frame so that unified solution for the physiological parameter and PET image reconstruction is achieved; statistical properties of system response and measurement are not assumed by the H-infinity theory, the H-infinity theory is impervious to noise types, and accordingly reconstruction robustness is improved effectively.

Description

technical field [0001] The invention belongs to the technical field of PET images, and in particular relates to a reconstruction method of PET physiological parameters based on H infinite filtering. Background technique [0002] Positron emission tomography (PET) is a medical imaging technology based on nuclear physics and molecular biology. in accordance with. When performing PET scanning, it is first necessary to inject drugs labeled with radioactive isotopes into the human body. Through the blood circulation system, these substances will form a certain distribution in various tissues and organs in the human body. Due to the short half-life of radioactive isotopes and their extreme instability, they will soon decay, and the positrons generated during the decay process will undergo an annihilation reaction with nearby free electrons, producing a pair of nearly opposite directions and equal energy, with a size of Gamma photons of 511keV are processed by the coincidence acq...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B6/03
Inventor 刘华锋郭敏胡正珲
Owner ZHEJIANG UNIV