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Microporous degradable collagen-chitosan nerve conduit and preparation method thereof

A technology of nerve conduits and chitosan, which is applied to human tubular structure devices, medical science, prostheses, etc., can solve the problems of non-biodegradable, non-degradable, tube wall sealing, etc., and achieve biodegradability, Improve the effect of repair and promote the effect of nerve regeneration

Active Publication Date: 2013-08-28
SHENZHEN YINGPULAN MEDICAL DEVICE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The object of the present invention is to provide a kind of microporous degradable collagen-chitosan nerve guide, which solves the problem of sealing the wall of the existing nerve guide tube, which is not conducive to the transportation of nutrients, oxygen and metabolites, and is not degradable or non-degradable in the body. Problems with good biodegradability

Method used

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  • Microporous degradable collagen-chitosan nerve conduit and preparation method thereof
  • Microporous degradable collagen-chitosan nerve conduit and preparation method thereof
  • Microporous degradable collagen-chitosan nerve conduit and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087] Weigh type I collagen and chitosan respectively, and the mass ratio of type I collagen and chitosan is 1:1;

[0088]Preparation mass volume percent concentration is 140mg / ml acetic acid solution; Measure the glacial acetic acid prepared by the quality of the type I collagen protein that takes by weighing, add the glacial acetic acid of 10ml for every gram type I collagen protein, mix the glacial acetic acid that measures and type I Collagens were mixed, and the suspension of type I collagen and glacial acetic acid was obtained through dissolving for 22 hours; the acetic acid solution was taken according to the mass of chitosan taken by weighing, and 37ml of acetic acid solution was added to every gram of chitosan , mix the measured acetic acid solution with chitosan, and dissolve for 22 hours to obtain a suspension of chitosan and acetic acid; mix the suspension of type I collagen and acetic acid with the suspension of chitosan and acetic acid The turbid liquids were mi...

Embodiment 2

[0093] Take type I collagen and chitosan respectively, and the mass ratio of type I collagen and chitosan is 4:1;

[0094] Preparation mass volume percent concentration is 140mg / ml acetic acid solution; Measure the glacial acetic acid prepared by the quality of the type I collagen protein that takes by weighing, add the glacial acetic acid of 10ml for every gram type I collagen protein, mix the glacial acetic acid that measures and type I Collagens were mixed, and the suspension of type I collagen and glacial acetic acid was obtained through dissolving for 22 hours; the acetic acid solution was taken according to the mass of chitosan taken by weighing, and 37ml of acetic acid solution was added to every gram of chitosan , mix the measured acetic acid solution with chitosan, and dissolve for 24 hours to obtain a suspension of chitosan and acetic acid; mix the suspension of type I collagen and acetic acid with the suspension of chitosan and acetic acid The turbid liquids were mi...

Embodiment 3

[0099] Take type I collagen and chitosan respectively, and the mass ratio of type I collagen and chitosan is 8:1;

[0100] Preparation mass volume percent concentration is 140mg / ml acetic acid solution; Measure the glacial acetic acid prepared by the quality of the type I collagen protein that takes by weighing, add the glacial acetic acid of 10ml for every gram type I collagen protein, mix the glacial acetic acid that measures and type I Collagens were mixed, and the suspension of type I collagen and glacial acetic acid was obtained through dissolving for 22 hours; the acetic acid solution was taken according to the mass of chitosan taken by weighing, and 37ml of acetic acid solution was added to every gram of chitosan , mix the measured acetic acid solution with chitosan, and dissolve it for 26 hours to obtain a suspension of chitosan and acetic acid; mix the suspension of type I collagen and acetic acid with the suspension of chitosan and acetic acid The turbid liquids are ...

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Abstract

The invention discloses a microporous degradable collagen-chitosan nerve conduit which comprises a cylindrical nerve conduit body. The cross section of the nerve conduit is ring-shaped. A preparation method of the nerve conduit is further disclosed. The method includes 1) weighing I-type collagen and chitosan; 2) placing the I-type collagen and the chitosan into acetum respectively and mixing two types of turbid liquid to prepare I-type collagen-chitosan gel-like turbid liquid; 3) pouring the I-type collagen-chitosan gel-like turbid liquid into a nerve conduit forming mould and conducting injection molding and cooling spraying solidification; 4) preparing the microporous degradable collagen-chitosan nerve conduit; and 5) conducting crosslinking and disinfection treatment on the nerve conduit. By means of the microporous degradable collagen-chitosan nerve conduit and the preparation method, the problem that the existing nerve conduit is not favorable for transportation of nutrient substances, oxygen and metabolite, is non-degradable or has poor biological degradability due to the fact that the wall of the nerve conduit is sealed is solved.

Description

technical field [0001] The invention belongs to the technical field of long-segment peripheral nerve injury repair, and relates to a microporous degradable collagen-chitosan nerve guide, and also relates to a preparation method of the above-mentioned nerve guide. Background technique [0002] Peripheral nerve defect is one of the most common traumas in clinical practice. This type of nerve injury will cause complete loss of both sensory and motor functions in the distal limbs innervated by the affected nerve, which will lead to severe disability. Quality of life has a huge impact. [0003] At present, clinically, for short-distance peripheral nerve defects, on the basis of the principle of tension-free suture, the method of direct suture of nerve stumps is often used for repair; for long-distance peripheral nerve defects, autologous nerve transplantation is often used. method to repair. However, studies have shown that: autologous nerve transplantation can only achieve par...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/04A61L27/26A61L27/56
Inventor 罗卓荆黄景辉马腾王宇清朱澍
Owner SHENZHEN YINGPULAN MEDICAL DEVICE
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