Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of polyflavanostilbene A in preparation of anti-tuberculosis bacteria medicaments

A technology of anti-tuberculosis bacteria and drugs, applied in the field of chemical compounds, can solve problems such as difficulties in tuberculosis prevention and treatment, and non-standard treatment and management of tuberculosis patients, and achieve the effect of strong inhibitory activity of tuberculosis bacteria, highlighting substantive characteristics, and expanding types

Inactive Publication Date: 2013-08-28
NANJING ZHENGLIANG MEDICAL TECH
View PDF1 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the irregular treatment and management of tuberculosis patients, irregular chemotherapy and abuse of anti-tuberculosis drugs, the drug resistance of tuberculosis is becoming more and more serious, and the change of drug resistance tends to be multi-drug resistance at the same time. great difficulty at work

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of polyflavanostilbene A in preparation of anti-tuberculosis bacteria medicaments
  • Application of polyflavanostilbene A in preparation of anti-tuberculosis bacteria medicaments
  • Application of polyflavanostilbene A in preparation of anti-tuberculosis bacteria medicaments

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1: the preparation of the compound Polyflavanostilbene A tablet involved in the present invention:

[0017] Take 20 grams of compound Polyflavanostilbene A, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press.

Embodiment 2

[0018] Embodiment 2: the preparation of the compound Polyflavanostilbene A capsules involved in the present invention:

[0019] Get 20 grams of compound Polyflavanostilbene A, add conventional auxiliary materials such as starch 180 grams for the preparation of capsules, mix well, and pack into capsules to make 1000 capsules.

[0020] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0021] Experimental example 1 Determination of the absolute concentration of Polyflavanostilbene A anti-BCG (BCG) by solid medium dilution method

[0022] Scrape the BCG culture from the slant, add it to 3ml Middlebrook7H9 broth medium, add a small amount of glass beads, tighten the test tube cap, vibrate and grind vigorously on the vortex oscillator, and compare it with the standard McFarland turbidimetric tube (MacFarland No.1) Turbidity, that is, to prepare 1mg / ml bacillus Calmette-Guerin (BCG) bacterial suspension. Make Polyflavanostilbene A into a high-concentration stock solution with DMSO, dilute the stock solution to the required concentration with 5% Tween-80 sterile ultrapure water, and add the diluted Polyflavanostilbene A to 4ml Middlebrook7H11 agar medium according to the required dose (The medium has been sterilized by high pressure steam at 121°C for 15 minutes, cooled to 50-55°C), mixed evenly, and made to contain Polyflavanostilbene A, the concentrations are 6...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an application of polyflavanostilbene A in preparation of anti-tuberculosis bacteria medicaments. The invention is designed against the current situation that the incidence rate and the mortality rate of tuberculosis are in a rising trend due to high incidence rate of the tuberculosis and the appearance of multiple-resistant strains of tuberculosis bacteria and finds that the polyflavanostilbene A has significant inhibition activity against the tuberculosis bacteria and further has good application prospects. The use of the polyflavanostilbene A in the preparation of the anti-tuberculosis bacteria medicaments, disclosed by the invention, belongs to the first disclosure, as the framework type belongs to the brand new framework type, the strong inhibition activity against the tuberculosis bacteria is unexpected, the possibility of giving any notices by other compounds does not exist, and the polyflavanostilbene A has prominent substantial characteristics; and simultaneously, the polyflavanostilbene A obviously has a significant progress in control of infection of the tuberculosis bacteria.

Description

technical field [0001] The present invention relates to a new application of compound Polyflavanostilbene A, in particular to the application of Polyflavanostilbene A in the preparation of anti-tuberculosis drugs. Background technique [0002] In recent years, the incidence of tuberculosis in the world has shown an increasing trend. According to the World Health Organization (WHO) estimates, the population infected by Mycobacterium tuberculosis (MTB) accounts for one-third of the world's population, of which 5-10% Infected people become TB patients. There are 1.3 million cases of active tuberculosis patients in my country every year, including about 600,000 cases of infectious tuberculosis, and about 600,000 cases of infectious tuberculosis. It is one of the countries with a high burden of tuberculosis in the world. [0003] Since the advent of anti-tuberculosis drugs one after another, the treatment of tuberculosis has played an epoch-making change. However, due to the ir...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P31/06
Inventor 不公告发明人
Owner NANJING ZHENGLIANG MEDICAL TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com