A kitasamycin antimicrobial nanoemulsion drug and a preparation method thereof

A technology of kitasamycin and antibacterial drugs, applied in the field of veterinary medicine, can solve problems such as being difficult to dissolve in water, unfavorable dosage forms, and affecting palatability, etc., and achieve the effects of clear and transparent appearance, significant curative effect, and good thermodynamic stability

Inactive Publication Date: 2013-09-11
SHAANXI SHENGAO ANIMALS PHARMA
View PDF2 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And combined with its preparation method, a kind of kitasarmycin nanoemulsion antibacterial drug with high bioavailability, small toxic and side effects, good stability and good palatability has been obtained, and it has overcome the difficulties of being difficult to dissolve in water, the dosage form is not conducive to application, and Defects that have a strong bitter taste, greatly affect palatability, and have a certain stimulating effect on the stomach

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Kitamycin nanoemulsion antimicrobial drug, the kititamycin nanoemulsion antibacterial drug is a composition with a particle size range of 1nm to 100nm and comprising kitamycin, an oil phase, a surfactant, a cosurfactant and distilled water, Wherein kitasamycin is 2.7g, glycerin formal as oily phase is 2.7g, the ethanol of 95% purity as co-surfactant is 10.9g, Tween-80 as surfactant is 27.4g and distilled water is 56.3g.

[0024] The preparation method of described kitasarmycin nanoemulsion antibacterial drug, the steps are as follows:

[0025] Step 1: Weigh 2.7g of kitasamycin, 2.7g of glycerol methylal, 10.9g of ethanol with 95% purity, 27.4g of Tween-80 and 56.3g of distilled water as kitasamycin, oil phase and co-surfactant respectively , surfactant and distilled water for standby;

[0026] Step 2: Put the weighed oil phase into the corresponding container, then add the weighed kitasamycin into the weighed oil phase, then mix the weighed kitasamycin and the weighed...

Embodiment 2

[0028] Kitamycin nanoemulsion antimicrobial drug, the kititamycin nanoemulsion antibacterial drug is a composition with a particle size range of 1nm to 100nm and comprising kitamycin, an oil phase, a surfactant, a cosurfactant and distilled water, Wherein kitasamycin is 4.3g, the isopropyl myristate as oily phase is 2g, the mixture that the ethanol of the 95% purity of 20g as co-surfactant and the 1.2-propanediol of 5g form, the poly 34 g of oxyethylene hydrogenated castor oil and 34.7 g of distilled water.

[0029] The preparation method of described kitasarmycin nanoemulsion antibacterial drug, the steps are as follows:

[0030] Step 1: Take by weighing 4.3g of kitasamycin, 2g of isopropyl myristate, 20g of 95% pure ethanol and 5g of 1.2-propylene glycol mixture, 34g of polyoxyethylene hydrogenated castor oil and 34.7g of distilled water as guitar mold respectively Primer, oil phase, cosurfactant, tensio-active agent and distilled water are standby;

[0031] Step 2: Put th...

Embodiment 3

[0033]Kitamycin nanoemulsion antimicrobial drug, the kititamycin nanoemulsion antibacterial drug is a composition with a particle size range of 1nm to 100nm and comprising kitamycin, an oil phase, a surfactant, a cosurfactant and distilled water, Wherein kitasamycin is 5g, the mixture that as the ethyl acetate of 4g of oily phase and the isopropyl myristate of 4g constitutes, the ethanol of 95% purity of 20g as co-surfactant, polyoxygen as surfactant Ethylene castor oil was 40 g and distilled water was 27 g.

[0034] The preparation method of described kitasarmycin nanoemulsion antibacterial drug, the steps are as follows:

[0035] Step 1: take by weighing the ethyl acetate of 5g, 4g and the isopropyl myristate mixture of 4g, the ethanol of 95% purity of 20g, the polyoxyethylene castor oil of 40g and the distilled water of 27g as guitar mold respectively Primer, oil phase, cosurfactant, tensio-active agent and distilled water are standby;

[0036] Step 2: Put the weighed oil...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
Login to view more

Abstract

A kitasamycin antimicrobial nanoemulsion drug and a preparation method thereof. The kitasamycin antimicrobial nanoemulsion drug is a composition having a particle size range of between 1nm to 100nm and comprising 0.1%-5% by weight of kitasamycin, 0.1%-8% by weight of an oil phase, 25%-40% by weight of a surfactant, and 4%-25% by weight of a cosurfactant, and the balance water. Combining the composition with the preparation method, the kitasamycin antimicrobial nanoemulsion drug with high bioavailability, low toxic and side effects, good stability, and good palatability is obtained.

Description

technical field [0001] The invention belongs to the field of veterinary medicine, and relates to a new dosage form of nano-medicine, in particular to a kitasarmycin nano-emulsion antibacterial drug and a preparation method thereof, in particular to a clear and transparent kitasarmycin nano-emulsion anti-bacterial drug and a preparation method thereof. Background technique [0002] Nanoemulsion is composed of oil phase, water phase, surfactant and co-surfactant mixed in appropriate proportions. The appearance should be a transparent or translucent liquid. Nanoemulsion is a low-viscosity, kinetically and thermodynamically stable system, the particle size should be between 1nm and 100nm. [0003] Kitamycin, also known as column crystal leucomycin, beilimycin, is a multi-component macrolide antibiotic produced by Streptomyces, which is white or light yellow powder, and can be dissolved in methanol, ethanol, chloroform, ether Easily soluble in water, almost insoluble in water. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/7048A61K47/44A61K47/34A61P31/04A61K47/26
Inventor 刘梅雪
Owner SHAANXI SHENGAO ANIMALS PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap