Acousto-optical-electric programmable random stimulator

A stimulator, acousto-optic technology, applied in the field of electrical programmable random stimulator, light, experimental device for preparing experimental animal models, and sound, can solve the problem of affecting the accuracy of experimental research results, reducing the degree of stress in model animals, and creating problems. Problems such as prolonging the molding time can be achieved to improve the efficiency of molding, broaden the application area, and increase the speed of molding

Inactive Publication Date: 2013-09-18
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Most of the devices used in the prior art to prepare animal models of hypertension use the method of plantar electric shocks with fixed time intervals combined with noise stimulation. There are following defects in the described method: o

Method used

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  • Acousto-optical-electric programmable random stimulator
  • Acousto-optical-electric programmable random stimulator
  • Acousto-optical-electric programmable random stimulator

Examples

Experimental program
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Embodiment 1

[0037] Such as Figure 1~3 As shown, the sound, light, and electricity programmable random stimulator consists of a single-chip microcomputer 1, a display screen 2, an input keyboard 3, a voltage sampling unit 4, a voltage regulating transformer 5, an electric shock control unit 6, an acousto-optic control unit 7, and an electric shock mouse. cage 8 and acousto-optic equipment 9; the single-chip microcomputer 1 is respectively connected to the display screen 2, the input keyboard 3, the voltage sampling unit 4, the motor control power supply 6 and the acousto-optic control unit 7, and the external power supply is connected to the voltage sampling through the voltage regulating transformer 5 The unit 4 and the motor control power supply 6 supply power, the motor control power supply 6 is connected to the electric shock mouse cage 8, and the acousto-optic control unit 7 is connected to the acousto-optic equipment 9;

[0038] The single-chip microcomputer 1 selects the C51F005 si...

Embodiment 2

[0046] Example 2 Preparation of stress-induced hypertension animal model

[0047] Establish conditioned reflexes with plantar electric shocks combined with noise stimulation to prepare animal models of stress-induced hypertension. Put 200-220g SD rats into electric shock cages with copper grids on the bottom (one in each cage); the size of electric shock cages The size is 22*22*26cm2, intermittent alternating current is passed through the copper grid, the shock voltage is 50-80V, and the power-on time is 50ms each time; the intensity of the buzzer is 90-100db at the same time as the electric shock, and the duration is 50ms of noise was used to establish conditioned reflexes; the interval time and combination of rat foot electric shock and noise stimulation were randomly controlled by the computer, that is, sometimes noise plus foot shock, and sometimes only noise stimulation. Stimulate twice a day, 2 hours each time, usually at 8:00 am to 10:00 am and 2:00 pm to 4:00 pm, with ...

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Abstract

The invention belongs to the technical field of experimental devices, relates to an experiment device for preparing an experimental animal model, in particular to an acousto-optical-electric programmable random stimulator, which consists of a singlechip, a display screen, an input keyboard, a voltage sampling unit, a voltage regulating transformer, an electric shock control unit, an acousto-optical control unit, an electric shock mouse cage and acousto-optical equipment, wherein the singlechip is connected with the display screen, the input keyboard, the voltage sampling unit, a motor control power supply and the acousto-optical control unit respectively; an external power supply is used for supplying power to the voltage sampling unit and the motor control power supply through the voltage regulating transformer; the motor control power supply is connected with the electric shock mouse cage; the acousto-optical control unit is connected with the acousto-optical equipment. As is proved by a using result, due to the adoption of the acousto-optical-electric programmable random stimulator, the learning and memorizing processes of the experimental animal model can be hindered, the formation of conditioned reflex is delayed, and the modeling efficiency is effectively increased; the stimulator can be applied to preparation of stress-induced hypertension animal models.

Description

technical field [0001] The invention belongs to the technical field of experimental devices, and relates to an experimental device for preparing experimental animal models, in particular to an acoustic, optical and electrical programmable random stimulator, which can be used for preparing stress-induced hypertension animal models. Background technique [0002] Animal experimentation is an indispensable means and method for scientific research in the fields of biomedicine and pharmacy, especially in pharmacology, physiology, neurobiology, zoology and other disciplines. Experimental animals are a necessary condition for exploring life phenomena and their essence, and are an important basis and supporting condition for life science research. With the help of indirect research on animal models, factors that are impossible or difficult to exclude under natural conditions can be consciously changed. In order to more accurately observe the experimental results of the model and cond...

Claims

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Application Information

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IPC IPC(8): A61D1/00
Inventor 杜东书曹银祥朱大年邓振旭楚德昌
Owner FUDAN UNIV
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