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Nanoemulsion gel made of radix sophorae flavescentis and earthworm and preparation method of nanoemulsion gel

A technology of nanoemulsion and ginseng, which is applied in the field of medicine to achieve the effect of low cost, large drug loading, and promoting healing

Active Publication Date: 2013-09-18
王英姿
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far there is no report about nanoemulsion gels that can effectively treat skin burns and scalds, skin eczema, dermatitis, skin itching and other skin diseases with small compound prescriptions of traditional Chinese medicines.

Method used

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  • Nanoemulsion gel made of radix sophorae flavescentis and earthworm and preparation method of nanoemulsion gel
  • Nanoemulsion gel made of radix sophorae flavescentis and earthworm and preparation method of nanoemulsion gel
  • Nanoemulsion gel made of radix sophorae flavescentis and earthworm and preparation method of nanoemulsion gel

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Embodiment 1. Preparation of Sophora flavescens Dilong nanoemulsion

[0063] Dissolve 0.2g of total alkaloids of Sophora flavescens into 0.15g of isopropyl myristate (IPM), add 1.89g of polyoxyethylene 35 castor oil (EL35) and 1.62g of absolute ethanol, dissolve and mix to form a drug-containing internal phase, and set the temperature at room temperature Stir at a constant speed until uniform; dissolve 0.1g of earthworm extract in water, then slowly add it dropwise to the inner phase containing the drug while stirring at room temperature, add water to a total weight of 10g, and stir at a constant speed until it is clear and transparent, that is, bitter Ginseng Dilong Nanoemulsion.

Embodiment 2

[0064] Embodiment 2. Preparation of Sophora flavescens Dilong nanoemulsion

[0065] Dissolve 0.1g of flavescens total alkaloids into 0.09g of isopropyl myristate, add 1.73g of polyoxyethylene 35 castor oil (EL35) and 1.36g of absolute ethanol, dissolve and mix to form a drug-containing internal phase, and keep the temperature at room temperature Stir until uniform; dissolve 0.2g of Earthworm extract in water, then slowly add it dropwise into the inner phase containing the medicine while stirring at room temperature, add water to a total weight of 10g, stir at a constant speed until clear and transparent, and obtain Sophora flavescens and Earthworm nanoemulsion.

Embodiment 3

[0066] Embodiment 3. Preparation of Sophora flavescens Dilong nanoemulsion gel

[0067] (1) Dissolve 0.2g of total alkaloids of Sophora flavescens into 0.15g of isopropyl myristate (IPM), add 1.89g of polyoxyethylene 35 castor oil (EL35) and 1.62g of absolute ethanol, dissolve and mix to form a drug-containing internal phase , stirred at a constant speed at room temperature until uniform; dissolved 0.1g of earthworm extract in water, then slowly added dropwise to the inner phase containing the drug while stirring at room temperature, added water to a total weight of 10g, and stirred at a constant speed until clear and transparent, Get liquid A.

[0068] (2) Weigh 0.02g of Carbomer 934 (CP-934), add 1mL (1.26g) of glycerin, grind and moisten, and disperse evenly to obtain liquid B.

[0069] (3) Add liquid A into liquid B, grind evenly, refrigerate and swell to obtain nanoemulsion gel.

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Abstract

The invention relates to the technical field of medicines and particularly relates to a nanoemulsion gel made of radix sophorae flavescentis and earthworm and a preparation method of the nanoemulsion gel. The nanoemulsion gel comprises the following components: alkaloids sophora flavescen, earthworm extract, an oil phase, a surfactant, a cosurfactant, gel substrate, glycerinum and water. The nanoemulsion gel can be used for treating the skin burns and scalds and the skin diseases such as skin eczema, dermatitis and skin itch, and enhancing fast healing of the wound surface of the burns and scalds. The nanoemulsion gel prepared by the invention is small and uniform in particle diameter, regular in form and good in stability, has little stimulation to the skin, is safe in use, large in skin penetration amount, high in skin penetration rate, obvious in medicine effect, and has good effect for enhancing healing of the wound surfaces of the skin. The preparation method is simple, and is low in cost, controllable in quality and conveneint and safe in use.

Description

technical field [0001] The present invention relates to the field of medical technology, in particular to a Sophora flavescens and Dilong nanoemulsion gel and a preparation method thereof. The Sophora flavescens and Dilong nanoemulsion gel can be used to effectively treat skin burns and scalds, skin eczema, dermatitis, and skin itching and other skin diseases, and can promote the rapid healing of burn wounds. Background technique [0002] Burns and scalds are relatively common body injuries in daily life and work. Eczema is a common clinical skin disease with a long course and difficult to cure, which seriously affects the quality of life of patients. Modern medicine mostly adopts drugs such as antibiotics for the treatment of burns, scalds and eczema. Although they can relieve symptoms in the acute phase, long-term use is prone to drug resistance, and the clinical use is limited. Traditional Chinese medicine has unique advantages in the treatment of burns, scalds and eczem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/489A61K9/06A61P17/00A61P17/02A61P17/04A61K35/56A61K35/62
Inventor 王英姿贺葵邦张超戴俊东冯艾灵孙秀梅
Owner 王英姿
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