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Composition for preventing or treating a respiratory disease containing a mixed herbal extract of cnidium officinale root and polygoni cuspidati root

A respiratory organ and disease prevention technology, which is applied in the field of respiratory organ disease prevention or treatment compositions containing Chuanqiong and Polygonum cuspidatum mixed crude drug extracts, can solve problems such as undisclosed effects of ethanol extracts, and achieve excellent 5-fatty oxygen High synthase inhibitory activity, antitussive and expectorant activity

Inactive Publication Date: 2013-09-25
WHANIN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this patent also does not disclose the effect of the ethanol extract of the mixture of Chuanqiong and Polygonum cuspidatum

Method used

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  • Composition for preventing or treating a respiratory disease containing a mixed herbal extract of cnidium officinale root and polygoni cuspidati root
  • Composition for preventing or treating a respiratory disease containing a mixed herbal extract of cnidium officinale root and polygoni cuspidati root
  • Composition for preventing or treating a respiratory disease containing a mixed herbal extract of cnidium officinale root and polygoni cuspidati root

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069]

[0070] Mix 50g Chuanqiong and 50g Polygonum cuspidatum, use 1000ml 50% ethanol aqueous solution, at 88°C for 4 hours each time, carry out 2 cycles of cooling and extraction, filter the extract and concentrate under reduced pressure. Based on the weight of the obtained concentrate, 5 times of distilled water was added to the concentrate again to prepare a suspension, which was then freeze-dried to obtain 29.8 g of mixed crude extracts of Chuanqiong and Polygonum cuspidatum in powder form.

Embodiment 2

[0071]

[0072] The crude extract obtained according to the method of Example 1, based on the weight, was added 10 times (v / w) pure water, and after the suspension was prepared, the same amount of water-saturated butanol (80% butanol aqueous solution) was added to carry out After two layer separations, only butanol was collected, filtered, and then concentrated under reduced pressure. After butanol and purified water are evaporated, about 100 ml of purified water is added to carry out azeotropic concentration, and this process is repeated twice to completely remove butanol. To the thus obtained concentrate, distilled water was added 5 times more by weight to prepare a suspension, and then freeze-dried to obtain 5.6 g of a powder fraction.

[0073] The following Examples 3-44 and Comparative Examples 1-5 were carried out under the conditions in Table 1 below, and other conditions were the same as those of Examples 1 and 2. However, for the water extract, after 8 hours of cir...

experiment example

[0077]

[0078] It was tested whether the mixed extracts prepared in Examples 1 to 44 and the extracts prepared in Comparative Examples 1 to 5 had an inhibitory effect on the activity of leukotriene-generating enzyme 5-lipoxygenase, which is the main pathogenesis of asthma.

[0079] For this purpose, rat basophilic leukemia cells (Rat basophilic leukemia cell, PBL-1) were used, and after stabilization at 37°C using serum-free RPMI medium, the extract was added, and peanut tetrachloride was added as a matrix. arachidonic acid (arachidonic acid), generating leukotrienes for 15 minutes. The amount of leukotrienes produced was detected using the cysteinyl leukotriene EIA kit. The 5-lipoxygenase inhibitors zileuton and montelukast were used as comparator drugs.

[0080] Table 2

[0081]

[0082]

[0083] As shown in Table 2 above, the mixed extracts of Examples 1 to 44 of the present invention have excellent 5-lipoxygenase inhibitory effects. Compared with the activity o...

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PUM

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Abstract

The present invention relates to a composition for preventing or treating a respiratory disease containing an active ingredient in the form of a mixed herbal extract of Cnidium officinale root (Cnidii Rhizoma) and Polygoni cuspidati root (Polygoni cuspidati Radix), and relates to a production method therefor. The mixed herbal extract of Cnidium officinale root and Polygoni cuspidati root has an outstanding 5-lipoxygenase suppressing activity, airway constriction suppressing activity, airway inflammation suppressing action, ear-swelling anti-inflammatory effect and antitussive and phlegm- loosening action, and has been confirmed to be useful in preventing or treating respiratory diseases including asthma, chronic obstructive pulmonary disease, acute and chronic bronchitis, allergic rhinitis, cough, expectoration, acute lower respiratory infections (bronchitis and bronchiolitis), and acute upper respiratory infections such as pharyngitis, tonsillitis and laryngitis.

Description

technical field [0001] The present invention relates to a composition for the prevention or treatment of respiratory diseases containing mixed extracts of Cnidii Rhizoma and Polygoni cuspidati Radix as active ingredients, in particular, a composition based on the mixed extracts of Cnidii Rhizoma and Polygoni cuspidati Radix. Excellent 5-lipoxygenase inhibitory activity, airway contraction inhibitory activity, airway inflammation inhibition and ear swelling anti-inflammatory effect, antitussive and expectorant activity, can effectively prevent or treat asthma, chronic obstructive pulmonary disease, acute and chronic bronchitis , Allergic rhinitis, cough, expectoration, acute lower respiratory tract infection (bronchitis and bronchiolitis), and respiratory diseases such as pharyngitis, tonsillitis, laryngitis and other acute upper respiratory tract infection. Background technique [0002] Asthma, chronic obstructive pulmonary disease, allergic rhinitis, cough, phlegm, acute an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/234A61K36/704A61P11/06A61P11/00
CPCA61K36/234A61K36/704A61P11/00A61P11/06A61K2300/00A61K36/70
Inventor 赵龙白姜文圭郑仁镐许钟铉金顺汉郑敬澈李悌荣金璱技李智荣俞炳哲玄旼炅
Owner WHANIN PHARMA CO LTD
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