Fixing device used for fixing back skin of experimental animal

Abstract

The invention relates to a fixing device used for fixing the back skin of an experimental animal. The fixing device used for fixing the back skin of the experimental animal comprises a base and fixing tables, wherein each fixing table comprises a connecting part and a fixing and clamping part connected with the connecting part, the fixing tables are connected with the base in a detachable mode through the connecting parts, the fixing and clamping parts of the two fixing tables are matched to form a fixing through hole allowing the experimental animal to pass through, and the end faces, away from the connecting parts, of the two fixing and clamping parts are matched to clamp the back skin of the experimental animal so that the back skin which is pulled up of the experimental animal can be spread on the outer walls of the fixing and clamping parts. The fixing device used for fixing the back skin of the experimental animal has the advantages that the back skin of the experimental animal can be fixed, negative influence of respiratory movement of the experimental animal on imaging is effectively avoided, damage to the experimental animal is small due to the fact the non-invasive fixing method is adopted, and long-time and stable observation and study of a subcutaneous transplantation tumor model on the back of the experimental animal by means of a photoacoustic imaging system is available.

Description

technical field [0001] The invention relates to the technical field of photoacoustic imaging, in particular to a fixing device for fixing the back skin of experimental animals. Background technique [0002] Photoacoustic imaging is a new non-invasive biomedical imaging technology that combines the advantages of optical imaging and ultrasound imaging. The principle of photoacoustic imaging is to inject pulsed laser light onto biological tissue, and the tissue will generate an ultrasonic signal due to instantaneous thermal expansion. The signal reflecting the light absorption information of the tissue can be obtained through the detection of the ultrasonic probe, thereby providing a comparison based on light absorption characteristics for imaging. mechanism. Moreover, the hemoglobin in biological tissue absorbs different wavelengths of light in different degrees, and the intensity of the excited photoacoustic signal is also different. Select a high absorption single waveleng...

AI Technical Summary

Problems solved by technology

This device is very harmful to mice, and careless operation can easily cause ischemia and infection to death. Moreover, the device must be installed in an ultra-clean environment throughout the process. The process is cumbersome and requires high operating environment and operators. The model was successful. low rate

Even if the model is successful, due to the large area of ​​skin damage, the survival time of mice is short, the longest is about 2-3 months, which is not conducive to long-term stable observation

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