Supercharge Your Innovation With Domain-Expert AI Agents!

Tamoxifen citrate dispersible tablets

A technology of tamoxifen and citric acid, applied in the field of dispersible tablets, can solve the problems of slow onset of action and low bioavailability

Active Publication Date: 2015-02-18
NANTONG GUANGTAI BIOCHEM PROD
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the shortcomings of slow onset of action and low bioavailability of existing tamoxifen citrate preparations, the present invention has invented tamoxifen citrate inclusion compound dispersible tablets

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Tamoxifen citrate dispersible tablets
  • Tamoxifen citrate dispersible tablets
  • Tamoxifen citrate dispersible tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Tamoxifen citrate inclusion complex: Tamoxifen citrate: α-cyclodextrin ratio 1:2

[0026]

[0027] Preparation:

[0028] 1. Prepare tamoxifen citrate inclusion compound according to the following method:

[0029] (1) In water or aqueous ethanol medium, react tamoxifen citrate with α-cyclodextrin in a certain proportion, filter the resulting solution through a microporous membrane until clarified, and separate the inclusion complex from the mixture thing; or

[0030] (2) In solid form, reacting tamoxifen citrate with alpha-cyclodextrin; or

[0031] (3) Tamoxifen citrate reacts with α-cyclodextrin for high-energy grinding.

[0032] 2. Mix the prescription amount of low-substituted hydroxypropyl cellulose, sodium carboxymethyl starch, sorbitol, cyclamate and tamoxifen citrate inclusion compound according to the equal addition method, and then add stearic acid Magnesium and micropowder silica gel, mixed evenly, and compressed into tablets to obtain tamoxifen citrate ...

Embodiment 1

[0034] Tamoxifen citrate inclusion complex: Tamoxifen citrate: α-cyclodextrin ratio 1:2

[0035]

[0036] The preparation method is the same as above

Embodiment 2

[0038] Tamoxifen citrate inclusion complex: Tamoxifen citrate: α-cyclodextrin ratio 1:2

[0039]

[0040] The preparation method is the same as above

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to tamoxifen citrate dispersible tablets, the preparation method of which comprises the steps of preparing tamoxifen citrates into clathrate compounds and further preparing the clathrate compounds into dispersible tablets.

Description

technical field [0001] The present application relates to a dispersible tablet, specifically, a tamoxifen citrate inclusion compound dispersible tablet. Background technique [0002] Tamoxifen (TAM) is a non-steroidal compound approved by the US Food and Drug Administration in 1977 for the treatment of metastatic breast cancer in postmenopausal women. After nearly 30 years of application history, it is now also used to prevent the occurrence of breast cancer. TAM belongs to the first generation of selective estrogen receptor modulators (selective estrogen receptor modulators, SERMs), which have dual effects of estrogen agonism and estrogen antagonism, and this effect depends on different germlines, tissues and gene expression types, Different target organs or target cells have different effects. For example, TAM produces antagonizing estrogen in mammary gland tissue, while it produces estrogen agonizing effect in uterus and bone tissue. TAM competes with estrogen for the ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/138A61K47/48A61P15/14A61P35/00
Inventor 李春涛李申申峰邱俊
Owner NANTONG GUANGTAI BIOCHEM PROD
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com