Tamoxifen citrate sustained-release granules
A technology of tamoxifen and sustained-release granules, applied in the field of sustained-release granules, can solve problems such as inconvenience in taking, slowing down the absorption rate, and prolonging the biological half-life.
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Embodiment 1
[0033] Example 1 Prescription
[0034] Tamoxifen citrate inclusion compound: Tamoxifen citrate: α-cyclodextrin ratio is 1:2
[0035] Tamoxifen citrate inclusion compound 18 parts
[0036] The composition of lactose and mannitol (the weight ratio of the two is 7.2:3) 13 parts
[0037] Composition of crospovidone and croscarmellose sodium (the weight ratio of the two is 2:5) 15 parts
[0038] Sodium saccharin 2 parts
[0039] Polymethacrylate 12 parts
[0040] Sodium carboxymethyl cellulose 7 parts
[0041] Preparation:
[0042] 1. Prepare tamoxifen citrate inclusion compound according to the following method:
[0043] (1) In water or aqueous ethanol medium, react tamoxifen citrate with α-cyclodextrin in a certain proportion, filter the resulting solution through a microporous membrane until clarified, and separate the inclusion complex from the mixture thing; or
[0044] (2) In solid form, reacting tamoxifen citrate with alpha-cyclodextrin; or
[0045] (3) Tamoxifen ci...
Embodiment 2
[0048] Fully grind tamoxifen citrate and α-cyclodextrin described in Example 1 in 50% ethanol to form a uniform paste, and obtain a white powder after vacuum drying. Tamoxifen citrate increased 12-fold.
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