Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Tamoxifen citrate sustained-release granules

A technology of tamoxifen and sustained-release granules, applied in the field of sustained-release granules, can solve problems such as inconvenience in taking, slowing down the absorption rate, and prolonging the biological half-life.

Active Publication Date: 2013-10-16
NANTONG GUANGTAI BIOCHEM PROD
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the shortcomings of the existing tamoxifen citrate preparations, which are inconvenient to take and have low bioavailability, the present invention has invented tamoxifen citrate inclusion complex sustained-release granules, which can reduce the number of times of taking medicine, slow down the absorption rate, prolong the Biological half-life, so that the blood concentration is controlled within the effective blood concentration range, thereby reducing side effects and improving patient compliance

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Tamoxifen citrate sustained-release granules
  • Tamoxifen citrate sustained-release granules
  • Tamoxifen citrate sustained-release granules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1 Prescription

[0034] Tamoxifen citrate inclusion compound: Tamoxifen citrate: α-cyclodextrin ratio is 1:2

[0035] Tamoxifen citrate inclusion compound 18 parts

[0036] The composition of lactose and mannitol (the weight ratio of the two is 7.2:3) 13 parts

[0037] Composition of crospovidone and croscarmellose sodium (the weight ratio of the two is 2:5) 15 parts

[0038] Sodium saccharin 2 parts

[0039] Polymethacrylate 12 parts

[0040] Sodium carboxymethyl cellulose 7 parts

[0041] Preparation:

[0042] 1. Prepare tamoxifen citrate inclusion compound according to the following method:

[0043] (1) In water or aqueous ethanol medium, react tamoxifen citrate with α-cyclodextrin in a certain proportion, filter the resulting solution through a microporous membrane until clarified, and separate the inclusion complex from the mixture thing; or

[0044] (2) In solid form, reacting tamoxifen citrate with alpha-cyclodextrin; or

[0045] (3) Tamoxifen ci...

Embodiment 2

[0048] Fully grind tamoxifen citrate and α-cyclodextrin described in Example 1 in 50% ethanol to form a uniform paste, and obtain a white powder after vacuum drying. Tamoxifen citrate increased 12-fold.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to tamoxifen citrate sustained-release granules, the preparation method of which comprises the steps of preparing tamoxifen citrates into clathrate compounds and further preparing the clathrate compounds into sustained-release granules.

Description

technical field [0001] The present application relates to a sustained-release granule, specifically, tamoxifen citrate inclusion compound sustained-release granule. Background technique [0002] Tamoxifen (TAM) is a non-steroidal compound approved by the US Food and Drug Administration in 1977 for the treatment of metastatic breast cancer in postmenopausal women. After nearly 30 years of application history, it is now also used to prevent the occurrence of breast cancer. TAM belongs to the first generation of selective estrogen receptor modulators (selective estrogen receptor modulators, SERMs), which have dual effects of estrogen agonism and estrogen antagonism, and this effect depends on different germlines, tissues and gene expression types, Different target organs or target cells have different effects. For example, TAM produces antagonizing estrogen in mammary gland tissue, while it produces estrogen agonizing effect in uterus and bone tissue. TAM competes with estro...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K47/48A61K47/26A61K47/38A61K47/32A61K47/22A61K31/138A61P35/00
Inventor 李春涛李申申峰邱俊
Owner NANTONG GUANGTAI BIOCHEM PROD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com