Preparation method of multifunctional medicine carrier integrating magnetism, fluorescence and thermosensitivity

A multi-functional, fluorescent technology, applied in preparations for in vivo experiments, drug combinations, pharmaceutical formulations, etc., can solve problems such as unseen technical methods, and achieve the effect of feasible process, broad application prospects, and reasonable design

Inactive Publication Date: 2013-11-13
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] After retrieving domestic and foreign patent documents, extensively consult domestic and foreign publications, up to now, have not yet seen the technical method completely identical with the present invention

Method used

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  • Preparation method of multifunctional medicine carrier integrating magnetism, fluorescence and thermosensitivity
  • Preparation method of multifunctional medicine carrier integrating magnetism, fluorescence and thermosensitivity
  • Preparation method of multifunctional medicine carrier integrating magnetism, fluorescence and thermosensitivity

Examples

Experimental program
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Embodiment 1

[0031] A schematic diagram of the preparation, drug loading and release of a multifunctional drug carrier integrating magnetism, fluorescence and thermosensitivity can be found in figure 1 , the detailed preparation steps are as follows: Dissolve 0.1mol ferric chloride, 0.1mol ferrous sulfate and 0.2mol thioglycolic acid in 50mL deionized water, raise the temperature to 60°C under magnetic stirring, and adjust the pH of the reaction system with NaOH solution to 7.0, a large amount of black ferric oxide particles were obtained, heated to 80°C and aged for 30 minutes, then centrifuged, washed, and dried to obtain a dry powder. in N 2 Atmosphere, magnetic stirring and alkaline aqueous solution (pH 9.0), add tellurium powder / sodium borohydride with a molar ratio of 1 / 2, and react at 80°C for 0.5h to obtain a deep red clear liquid, which is the precursor of sodium telluride hydride , and then take part of it and quickly add it to the mixed aqueous solution of cadmium chloride and ...

Embodiment 2

[0034] The detailed preparation steps are as follows: Dissolve 0.2mol ferric chloride, 0.1mol ferrous sulfate and 0.3mol thioglycolic acid in 50mL deionized water, raise the temperature to 70°C under magnetic stirring, and adjust the pH of the reaction system to 7.5 with NaOH solution , to obtain a large number of black iron ferric oxide particles, which were aged at 80°C for 30 minutes, then centrifuged, washed, and dried to obtain dry powder. in N 2 Atmosphere, magnetic stirring and alkaline aqueous solution (pH10.0), add tellurium powder / sodium borohydride with a molar ratio of 1 / 2, and react at 80°C for 0.5h to obtain a deep red clear liquid, which is the precursor of sodium telluride hydride body, and then take part of it and quickly add it to the mixed aqueous solution of cadmium chloride and glutathione, wherein the molar ratio of sodium hydride telluride / cadmium chloride / glutathione is 1 / 5 / 10, and react at 85°C for 4h Preparation of cadmium telluride quantum dots. We...

Embodiment 3

[0036] The detailed preparation steps are as follows: Dissolve 0.3mol ferric chloride, 0.1mol ferrous sulfate and 0.4mol thioglycolic acid in 50mL deionized water, raise the temperature to 80°C under magnetic stirring, and adjust the pH of the reaction system to 8.0 with NaOH solution , to obtain a large number of black iron ferric oxide particles, which were aged at 80°C for 30 minutes, then centrifuged, washed, and dried to obtain dry powder. in N 2 Atmosphere, magnetic stirring and alkaline aqueous solution (pH11.0), add tellurium powder / sodium borohydride with a molar ratio of 1 / 2, and react at 80°C for 0.5h to obtain a deep red clear liquid, which is the precursor of sodium telluride hydride body, and then take part of it and quickly add it to the mixed aqueous solution of cadmium chloride and glutathione, wherein the molar ratio of sodium hydride telluride / cadmium chloride / glutathione is 1 / 10 / 12, and react at 80°C for 4h or less Preparation of cadmium telluride quantum ...

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Abstract

The invention relates to a preparation method of a multifunctional medicine carrier integrating magnetism, fluorescence and thermosensitivity. The carrier structure uses chitosan microspheres grafted by poly(N-isopropyl acrylamide) as a main body internally crosslinked with porous silicon nano particles. The nano particles encapsulate superparamagnetic nano particles and inorganic quantum dots, so that a composite microsphere carrier which takes porous silicon nano particles loading magnetic particles and quantum dots as a core and chitosan grafted by poly(N-isopropyl acrylamide) as a shell is formed. The carrier can load the anti-cancer medicine in a shell network of a polymer so as to sequentially release the medicine at special temperatures. Compared with the prior art, the medicine carrier provided by the invention has hydrophilcity and biocompatibility, so that the anti-cancer medicine is controllably encapsulated and released. Meanwhile, the medicine carrier has magnetic targeting fluorescent tracing functions, and has important research and application values in associated fields of biology, medicines and materials such as sustained-release materials, medicine carriers, catalyst carriers and separating media.

Description

technical field [0001] The invention belongs to the technical field of functional polymer materials, and in particular relates to a multifunctional drug carrier integrating magnetism, fluorescence and heat sensitivity and a preparation method thereof. Background technique [0002] Multifunctional drug carrier refers to the integration of multiple functionalized carrier materials in a single and stable system through ingenious design to achieve specific purposes, such as prolonging blood circulation time, targeting effect, physiological sensitivity (temperature or pH), Controlled drug release, simultaneous loading of therapeutic agents, imaging agents or contrast agents, etc. Multifunctional drug carriers can be used as an effective platform for the delivery of various drugs. By identifying the unique surface signals of targeted cells and the controllable and orderly release of drugs, the drugs can exert synergistic effects and significantly reduce the toxic and side effects ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/36A61K47/32A61K47/24A61K47/02A61K49/00A61K31/704A61P35/00
Inventor 万锕俊桂日军李慧丽金辉
Owner SHANGHAI JIAO TONG UNIV
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