Polymer-coated gold nanoparticle chain compound, preparation method and applications thereof

A gold nanoparticle and polymer technology, which can be applied to medical preparations without active ingredients, medical preparations containing active ingredients, and materials for wave energy or particle radiation treatment. "Melting effect and other problems, to achieve the effect of low risk, simple experimental operation, and good experimental repeatability.

Inactive Publication Date: 2013-11-20
JILIN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Taking the precious metal gold as an example, gold can be prepared in various shapes, such as gold rods, flake gold, star gold and cage gold. They have good absorption of near-infrared light, so they are widely used for photothermal properties. However, the preparation process of t

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  • Polymer-coated gold nanoparticle chain compound, preparation method and applications thereof
  • Polymer-coated gold nanoparticle chain compound, preparation method and applications thereof
  • Polymer-coated gold nanoparticle chain compound, preparation method and applications thereof

Examples

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Example Embodiment

[0022] In the following, the present invention will be further described in combination with the embodiments, instead of limiting the present invention. Example 1

[0023] Add 1.5×10 to 5mL, 0.286mmol / L sodium citrate stabilized gold nanoparticle aqueous solution -6 mol of pyrrole, grow at room temperature for 2 hours, then add SDS1.2×10 -5 mol terminates the chain growth process, thereby obtaining a gold nanoparticle chain with an average chain length of 4.

Example Embodiment

[0024] Example 2

[0025] Add 1.5×10 to 5mL 0.286mmol / L sodium citrate stabilized gold nanoparticle aqueous solution -6 mol of pyrrole, grow at room temperature for 3 hours, then add SDS1.2×10 -5 mol terminates the chain growth process. Gold nanoparticle chains with an average chain length of 6.

Example Embodiment

[0026] Example 3

[0027] Add 1.5×10 to 5mL 0.286mmol / L sodium citrate stabilized gold nanoparticle aqueous solution -6 mol of pyrrole, grown at room temperature for 7 hours, then add SDS1.2×10 -5 mol terminates the chain growth process. Gold nanoparticle chains with an average chain length of 10.

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Abstract

The invention discloses a polymer-coated gold nanoparticle chain compound, a preparation method and applications thereof, and belongs to the technology field of functional materials. Gold chain assemblies with various lengths are obtained through controlling the growth time of self-assembly gold chains or the quantity of electrolyte which triggers the chains to grow in the preparation method, and then the gold chain assemblies are coated with a polymer layer which is used for stabilizing the gold chain assemblies to improve the glue stability and laser irradiation stability of the gold chain assemblies. The compound has an excellent photo-thermal conversion property, and after being irradiated by a laser with a density of 3.5 W/cm2 and a wavelength of 808 nm for 5 minutes, the temperatures of nano compounds with average chain lengths of 2, 4, 6, 10 and 12 respectively raise by 48.4, 49.2, 50.3, 52.8 and 54.4 DEG C in an open system at the room temperature of 20 DEG C. The nano compound material is an excellent photo-thermal therapeutic agent.

Description

technical field [0001] The invention belongs to the technical field of functional materials, and specifically relates to a polymer-coated gold nanoparticle chain composite with different chain lengths. The composite has ultra-high photothermal conversion efficiency and can be used as a photothermal therapy reagent for 808nm laser Irradiation kills tumor cells without destroying healthy tissues and organs. Background technique [0002] Damage-free treatment of tumor cells has long been a goal of researchers. The near-infrared light of 700-900nm belongs to the optical window of biological tissues, and the use of near-infrared light to irradiate photothermal reagents to generate heat to kill tumor cells has become a research hotspot. This property of converting light into heat and minimizing damage to human tissues and organs has a wide range of potential applications in diagnostic and therapeutic methodologies. There are a wide variety of nano-reagents for photothermal thera...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K47/32A61P35/00
Inventor 张皓林敏李晶杨柏
Owner JILIN UNIV
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