Tunnel-type hydrogen peroxide sterilization method and tunnel-type hydrogen peroxide sterilization device

A technology of hydrogen peroxide and sterilizing equipment, applied in chemistry and other fields, can solve problems such as cross-contamination, high labor intensity, and inability to meet the requirements of continuous production, and achieve the effect of ensuring sterility indicators and increasing production speed

Inactive Publication Date: 2013-12-04
叶明 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is a discontinuous production, and its discharge process can only be transferred by laminar flow vehicles. The transfer process has the risk of cross-contamination, and the labor intensity is high and the production efficiency is low.
Its main disadvantage: the replacement time (i.e. degradation time) after sterilization is long, which cannot meet the requirements of continuous production

Method used

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  • Tunnel-type hydrogen peroxide sterilization method and tunnel-type hydrogen peroxide sterilization device
  • Tunnel-type hydrogen peroxide sterilization method and tunnel-type hydrogen peroxide sterilization device

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specific Embodiment approach

[0036] Such as figure 1 Shown, a kind of tunnel type hydrogen peroxide sterilization method comprises the following steps:

[0037] (1) Initial drying of the bottle body: First blow hot air at 60-70°C evenly into the tunnel-type hydrogen peroxide sterilizer, stop blowing hot air when the temperature inside the box is 60-70°C, and then clean the box body The interior is vacuumed to 50-100Pa, and the initial drying is completed. After this process, the water in the bottle is basically discharged;

[0038] (2) Pretreatment period: heating inside the hydrogen peroxide generator, heating the vaporization system of the hydrogen peroxide generator to the set working temperature;

[0039] (3) Sterilization period: Under the action of the hydrogen peroxide generator, the gaseous hydrogen peroxide vapor is pressed in for many times, and the concentration of the hydrogen peroxide vapor is maintained at a level lower than the saturated state to sterilize the bottle body in the box. Bact...

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Abstract

The invention discloses a tunnel-type hydrogen peroxide sterilization method. The method includes the following steps of preliminary drying of a bottle, pretreating, sterilizing, replacing and later degrading. By vacuumizing the interior of a box and a box pressure-restoring pipeline for replenishing fresh air, most of vaporized hydrogen peroxide is degraded; residual hydrogen peroxide is further degraded in a front/rear buffering portion through laminar flow air, so that concentration 1ppm of hydrogen peroxide outgoing from the plastic bottle of equipment and left by operating personnel of the equipment meets requirements of laws and regulations, production speed is increased, and sterility indicators of the plastic bottle are guaranteed by the clean laminar flow air of the front/rear buffering portion.

Description

technical field [0001] The invention relates to a sterilization method, more precisely, a tunnel type hydrogen peroxide sterilization method which can solve the problem of excessive hydrogen peroxide remaining in bottles after sterilization in the prior art. Background technique [0002] In pharmaceutical production, pharmaceutical packaging materials similar to plastics that cannot be sterilized by high temperature are often encountered, such as bottles in eye drops. Originally, eye drop bottles were treated with low temperature or ozone disinfection. After the promulgation of the new version of GMP (2010) regulations, all products involving sterility inspection items listed in the statutory drug standards are included in the management scope of aseptic production, so most eye drop packaging materials need to be sterilized, low temperature or ozone Disinfection is difficult to meet the requirements of GMP and "Chinese Pharmacopoeia" regulations. Among the sterilization pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L2/20A61L101/22
Inventor 叶明田耀华
Owner 叶明
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