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Application of Lycojaponicumin B in antibacterial drug

An anti-bacterial and drug-based technology, applied in the direction of anti-bacterial drugs, resistance to vector-borne diseases, medical preparations containing active ingredients, etc., can solve problems such as digestive tract irritation and strong accumulation of toxicity

Active Publication Date: 2013-12-18
王晓燕
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The spread of pathogenic bacteria and the enhancement of drug resistance seriously threaten human health and life. Antibacterial drugs have been widely used as routine drugs in the treatment of AIDS, organ transplantation and chronic wasting diseases (such as cancer, diabetes, uremia, etc.) Treatment, although antibacterial agents currently used clinically (such as ketoconazole, amikacin, gentamicin, vigorconazole, itraconazole, terbinafine, amphotericin, fluconazole, etc.) The curative effect on skin and superficial infection is good, but these antibacterial drugs have strong cumulative toxicity, often causing liver and kidney damage, gastrointestinal irritation, dizziness, allergies, etc. one of the hotspots

Method used

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  • Application of Lycojaponicumin B in antibacterial drug
  • Application of Lycojaponicumin B in antibacterial drug
  • Application of Lycojaponicumin B in antibacterial drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Example 1: Preparation of Lycojaponicumin B tablet of the compound involved in the present invention:

[0013] Take 20 grams of compound Lycojaponicumin B, add 180 grams of conventional excipients for preparing tablets, mix them, and prepare 1,000 tablets with a conventional tablet press.

Embodiment 2

[0014] Example 2: Preparation of the compound Lycojaponicumin B capsule of the present invention:

[0015] Take 20 grams of the compound Lycojaponicumin B, add it to the conventional auxiliary materials for preparing capsules, such as 180 grams of starch, mix well, and encapsulate to make 1000 tablets.

[0016] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example

[0017] Experimental example: Lycojaponicumin B antibacterial activity

[0018] The antibacterial activity experiment adopts the concentration dilution method, and each measurement is repeated three times. The test pathogens include Escherichia coli, Pseudomonas fluorescens, Staphylococcus aureus, Proteus, Cryptococcus neoformans, and the concentration of the bacterial solution is 10 5 Pieces / mL. The initial concentration of Lycojaponicumin B is 50.0 μg / mL (5% dimethyl sulfoxide DMSO), and the gradient is diluted to 0.098 μg / mL. The same volume of bacterial liquid and test sample are mixed and cultured in a 96-well plate. The bacterial culture temperature is respectively It is 37°C and observed after 24 hours of incubation. If no colony is found, it is the lowest antibacterial concentration of the sample, that is, the MIC value. The positive control of this experiment is amikacin sulfate, and the antibacterial results of Lycojaponicumin B are shown in Table 1.

[0019] Table 1 Anti...

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Abstract

The invention relates to application of Lycojaponicumin B in preparation of an antibacterial drug and belongs to the field of medicine. The Lycojaponicumin B has good inhabiting effect on escherichia coli, pseudomonas fluorescens, staphylococcus aureus, proteus vulgaris and cryptococcus neoformans, so that the Lycojaponicumin B can serve as an antibacterial compound and is hopefully applied to the preparation of related drugs. The application of the Lycojaponicumin B in the preparation of the antibacterial drug is disclosed for the first time. Due to the fact that the skeleton type is a novel skeleton type and the high bacteriostasis activity of the Lycojaponicumin B is previously unimagined, the possibility that other compounds give any revelation does not exist, and the Lycojaponicumin B has outstanding substantive characteristics and meanwhile has a remarkable improvement in prevention and treatment of bacterial infection obviously.

Description

Technical field [0001] The present invention relates to the use of Lycojaponicumin B, in particular to the use of Lycojaponicumin B in the preparation of antibacterial drugs. Background technique [0002] The spread of pathogenic bacteria and the enhancement of their drug resistance are a serious threat to human health and life. Antibacterial drugs have been widely used as routine drugs for AIDS, organ transplantation and chronic wasting diseases (such as cancer, diabetes, uremia, etc.) Treatment, although the current clinical use of antibacterial agents (such as ketoconazole, amikacin, gentamicin, viviconazole, itraconazole, terbinafine, amphotericin, fluconazole, etc.) It has a good effect on skin and superficial infections, but these antibacterial drugs have strong accumulated toxicity and often cause liver and kidney damage, digestive tract irritation, dizziness, allergies, etc., so the search for new antibacterial drugs with unique mechanisms of action has become today's dru...

Claims

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Application Information

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IPC IPC(8): A61K31/424A61P31/04
CPCY02A50/30
Inventor 江春平吴俊艺
Owner 王晓燕
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