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Application of incarviatone A in preparation of medicine for treating yellow fever virus infection

A yellow fever virus and drug technology, applied in antiviral agents, pharmaceutical formulations, and resistance to vector-borne diseases, etc., to achieve huge social benefits and research value

Inactive Publication Date: 2015-11-25
刘玮 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there have been no cases reported in China, but this does not make us relax our vigilance against the virus, because China's climate and geographical environment are complex, and there are many types of mosquitoes, which have the conditions for transmission. At the same time, with the increasing frequency of international exchanges, YFV It is very likely that it will be introduced into China

Method used

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  • Application of incarviatone A in preparation of medicine for treating yellow fever virus infection
  • Application of incarviatone A in preparation of medicine for treating yellow fever virus infection
  • Application of incarviatone A in preparation of medicine for treating yellow fever virus infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1: the preparation of compound IncarviatoneA tablet involved in the present invention:

[0037] Get 20 grams of compound Incarviatone A, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press.

Embodiment 2

[0038] Embodiment 2: the preparation of compound IncarviatoneA capsules involved in the present invention:

[0039] Get 20 grams of compound Incarviatone A, add conventional auxiliary materials for preparing capsules such as 180 grams of starch, mix well, and pack into capsules to make 1000 tablets.

[0040] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0042] A kind of application of IncarviatoneA in the preparation treatment or prevention yellow fever virus infection medicine, its steps are:

[0043] A. Toxicity test of Incarviatone A on Vero cells

[0044] Vero cells (African green monkey kidney cells) are susceptible cells to YFV.

[0045] The experimental steps are as follows:

[0046] 1: Inoculate Vero cells: use DMEM medium containing 10% (v / v) fetal bovine serum to make a single cell suspension, inoculate 1000-10000 cells per well into a 96-well cell culture plate, and inoculate a volume of 100ul per well ;

[0047] 2: Culture Vero cells: at 37°C, 5% (v / v) CO 2 Under culture conditions, cultivate for 2 days;

[0048] 3: Add Incarviatone A: Absorb the DMEM medium in each well, add 100ul to each well and dilute to the corresponding concentration (0uM, 0.4uM, 1.2uM) with DMEM medium containing 10% (v / v) fetal calf serum , 3.7uM, 11uM, 33uM, 100uM, 300uM) of IncarviatoneA, the control wells were added without adding ...

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Abstract

The invention discloses an application of Incarviatone A in medicaments for treating yellow fever virus infection. The Incarviatone A can effectively inhibit proliferation of yellow fever viruses, but has low toxicity to cells, can be further developed into the medicaments for treating diseases caused by the yellow fever virus infection, and has a wide application prospect. The application of the Incarviatone A in preparation of the medicaments for treating the yellow fever virus infection is made public for the first time, the skeleton type is completely novel, and the Incarviatone A has an unexpectedly strong yellow fever virus inhibiting activity, so the probability that other compounds give any revelation does not exist, outstanding substantive features are provided, meanwhile, prominent improvement is evidently possessed in prevention and treatment of the yellow fever virus infection.

Description

technical field [0001] The invention belongs to the field of biomedicine, and more specifically relates to the application of Incarviatone A in the preparation of medicines for treating or preventing yellow fever virus infection. Background technique [0002] Yellow fever virus (yellowfevervirus, YFV) is a member of the Flavivirus genus of the family Flaviviridae. Yellow fever virus causes yellow fever, an acute infectious disease. Yellow fever has been designated as a quarantine infectious disease internationally, and China has also designated it as a Class A infectious disease. In 1648, the YUCATAN peninsula in America first confirmed the prevalence of yellow fever. From the 17th to the 19th century, the disease was brought to Europe and North America through transportation. Within two centuries, yellow fever became one of the most serious plagues in some parts of the United States, Africa, and Europe, causing a large number of deaths. Since the 20th century, the diseas...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61P31/14
CPCY02A50/30
Inventor 刘玮
Owner 刘玮
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