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Application of lycojaponicumin C in preparation of medicine for treating yellow fever virus infection

A yellow fever virus and drug technology, applied in antiviral agents, pharmaceutical formulations, and resistance to vector-borne diseases, etc., to achieve huge social benefits and research value

Inactive Publication Date: 2015-12-09
重庆市黔江区阿蓬科技企业孵化器有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there have been no cases reported in China, but this does not make us relax our vigilance against the virus, because China's climate and geographical environment are complex, and there are many types of mosquitoes, which have the conditions for transmission. At the same time, with the increasing frequency of international exchanges, YFV It is very likely that it will be introduced into China

Method used

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  • Application of lycojaponicumin C in preparation of medicine for treating yellow fever virus infection
  • Application of lycojaponicumin C in preparation of medicine for treating yellow fever virus infection
  • Application of lycojaponicumin C in preparation of medicine for treating yellow fever virus infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1: the preparation of the compound LycojaponicuminC tablet involved in the present invention:

[0037] Take 20 grams of compound Lycojaponicumin C, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press.

Embodiment 2

[0038] Embodiment 2: the preparation of compound LycojaponicuminC capsules involved in the present invention:

[0039] Get 20 grams of compound Lycojaponicumin C, add conventional adjuvants such as starch 180 grams for preparing capsules, mix well, pack into capsules and make 1000 tablets.

[0040] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0042] A kind of application of LycojaponicuminC in the preparation treatment or prevention yellow fever virus infection medicine, its steps are:

[0043] Toxicity test of A.LycojaponicuminC on Vero cells

[0044] Vero cells (African green monkey kidney cells) are susceptible cells to YFV.

[0045] The experimental steps are as follows:

[0046] 1: Inoculate Vero cells: use DMEM medium containing 10% (v / v) fetal bovine serum to make a single cell suspension, inoculate 1000-10000 cells per well into a 96-well cell culture plate, and inoculate a volume of 100ul per well ;

[0047] 2: Culture Vero cells: at 37°C, 5% (v / v) CO 2 Under culture conditions, cultivate for 2 days;

[0048] 3: Add LycojaponicuminC: Aspirate and discard the DMEM medium in each well, add 100ul to each well and dilute to the corresponding concentration (0uM, 0.4uM, 1.2uM) with DMEM medium containing 10% (v / v) fetal calf serum , 3.7uM, 11uM, 33uM, 100uM, 300uM) of LycojaponicuminC, the control well was ...

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Abstract

The invention discloses an application of Lycojaponicumin C in the preparation of medicines for treating or preventing yellow fever virus infection. The Lycojaponicumin C can be used for effectively inhibiting the proliferation of yellow fever virus, has very low toxicity on cells, can be further developed into the medicines for treating diseases caused by the virus infection and has wide application prospects. The application of the Lycojaponicumin C in the preparation of medicines for treating the yellow fever virus infection is disclosed for the first time. As the skeleton type of the Lycojaponicumin C belongs to a brand-new skeleton type, the Lycojaponicumin C has unexpected strong inhibitory activity on yellow fever virus, and the possibility that other compounds provide revelation does not exist. The Lycojaponicumin C has prominently substantial characteristics and meanwhile has remarkably progressive significance when being used for preventing or treating the yellow fever virus infection.

Description

technical field [0001] The invention belongs to the field of biomedicine, and more specifically relates to an application of LycojaponicuminC in preparing medicines for treating or preventing yellow fever virus infection. Background technique [0002] Yellow fever virus (yellowfevervirus, YFV) is a member of the Flavivirus genus of the family Flaviviridae. Yellow fever virus causes yellow fever, an acute infectious disease. Yellow fever has been designated as a quarantine infectious disease internationally, and China has also designated it as a Class A infectious disease. In 1648, the YUCATAN peninsula in America first confirmed the prevalence of yellow fever. From the 17th to the 19th century, the disease was brought to Europe and North America through transportation. Within two centuries, yellow fever became one of the most serious plagues in some parts of the United States, Africa, and Europe, causing a large number of deaths. Since the 20th century, the disease has no...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/438A61P31/14
CPCY02A50/30
Inventor 张红丽
Owner 重庆市黔江区阿蓬科技企业孵化器有限公司
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