Irradiation crosslinked chitosan/gelatin/polyvinyl alcohol hydrogel dressing as well as preparation method and application thereof

A technology of cross-linking chitosan and polyvinyl alcohol, used in medical science, absorbent pads, bandages, etc., can solve the problem of insufficient strength, toughness and absorption and exudation capacity, poor antibacterial, anti-inflammatory and hemostatic properties, hydrogel dressings Complex preparation process and other problems, to achieve the effect of promoting wound healing, relieving wound pain, and promoting rapid wound healing

Active Publication Date: 2014-01-01
江西金思康药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

CN27724714 discloses " hydrogel chitosan medical dressing ", and it is beneficial to wound absorption, promotes wound healing, has better effects such as hemostasis, anti-inflammatory pain relief, healing cicatrix; But its composition is single, strength, toughness and absorption permeability There are deficiencies in liquid capacity, etc.
CN102895699 discloses "a composite hydrogel dressing for skin wound repair", the main components of which are hyaluronic acid and type I collagen, cross-linked by sodium trimetaphosphate, and the cross-linked product is rinsed and soaked in deionized water, A clean hydrogel dressing can only be obtained by removing impurities such as cross-linking agents and alkalis; although the hydrogel dressing can quickly promote skin wound healing, the residual impurities

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] (1) Preparation of solution A: Weigh 20g of gelatin particles with a relative molecular weight of 90,000 and a purity greater than 90% and grind them into powder, add them to 20ml of warm water, and stir until the gelatin is completely dissolved;

[0024] (2) Preparation of solution B: Take 30ml of ultrapure water and adjust the pH to 6 with formic acid, grind 10g of chitosan with a relative molecular weight of 35,000 to powder form, add it to ultrapure water and stir until the chitosan is completely dissolved;

[0025] (3) Preparation of solution C: Weigh 6g of polyvinyl alcohol with a degree of polymerization of 1700, a purity of more than 90%, and a degree of alcoholysis of 99%, grind it into powder, add it to 10ml of ultrapure water, and stir until polyvinyl alcohol Vinyl alcohol is completely dissolved;

[0026] (4) Slowly add solutions B and C to solution A and stir until uniform;

[0027] (5) irradiating and crosslinking the mixed solution of the product obtaine...

Embodiment 2

[0032] (1) Preparation of solution A: Weigh 10g of gelatin particles with a relative molecular weight of 90,000 and a purity greater than 90% and grind it into powder, add it to 20ml of warm water, and stir until the gelatin is completely dissolved;

[0033] (2) Preparation of solution B: take 30ml of ultrapure water and adjust the pH to 5 with formic acid, grind 20g of chitosan with a relative molecular weight of 50,000 to powder form, add it to distilled water and stir until the chitosan is completely dissolved;

[0034] (3) Preparation of solution C: Weigh 8g of polyvinyl alcohol with a degree of polymerization of 1700, a purity of more than 90%, and a degree of alcoholysis of 99%, grind it into powder, add it to 10ml of ultrapure water, and stir until polyvinyl alcohol Vinyl alcohol is completely dissolved;

[0035] (4) Slowly add solutions B and C to solution A and stir until uniform;

[0036] (5) Cross-linking the mixed solution obtained in step (4) by gamma photon irra...

Embodiment 3

[0041] (1) Preparation of solution A: Weigh 15g of gelatin particles with a relative molecular weight of 90,000 and a purity greater than 90% and grind it into powder, add it to 20ml of warm water, and stir until the gelatin is completely dissolved

[0042](2) Preparation of solution B: take 30ml of ultrapure water and adjust the pH to 6 with formic acid, grind 30g of chitosan with a relative molecular weight of 100,000 into powder, add it to ultrapure water and stir until the chitosan is completely dissolved;

[0043] (3) Preparation of solution C: Weigh 10g of polyvinyl alcohol with a degree of polymerization of 1700, a purity of more than 90%, and an alcoholysis degree of 99% and grind it into powder, add it to 10ml of ultrapure water, and stir until the polyethylene Alcohol is completely dissolved;

[0044] (4) Slowly add solutions B and C to solution A and stir until uniform;

[0045] (5) subjecting the mixed solution obtained in step (4) to cross-linking by high-energy ...

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PUM

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Abstract

The invention discloses an irradiation crosslinking chitosan/gelatin/polyvinyl alcohol hydrogel dressing as well as a preparation method and an application thereof. The preparation method comprises the steps that a chitosan, gelatin and polyvinyl alcohol solution is prepared by using ultrapure water serving as a solvent; the solution is stirred and mixed uniformly and then irradiated, and original hydrogel is obtained; the original hydrogel is put into the ultrapure water to be soaked; and the chitosan/gelatin/polyvinyl alcohol hydrogel dressing is prepared. The hydrogel dressing is extensive in raw material source, simple in preparation technology and stable in performance, and has the advantages of inflammation diminishing, wound pain relieving, scar reduction, wound healing promotion, wound seepage absorption, and excellent biocompatibility. The hydrogel dressing is easy to degrade after abandoned, and has a smaller influence on an environment. The hydrogel dressing can be applied to the fields of trauma hemostasis, inflammation diminishing, scald, postoperative wound healing and the like.

Description

technical field [0001] The invention belongs to the field of medical polymer materials, and in particular relates to an irradiation crosslinked chitosan / gelatin / polyvinyl alcohol hydrogel dressing, its preparation method and its application in medical treatment. Background technique [0002] Dressing is an essential medical product. The combination of sterile gauze and topical antibiotics is the traditional dressing. However, in traditional dressings, the gauze is easy to adhere to the skin wound tissue. Changing the dressing often destroys the new epithelium and granulation tissue, causing bleeding, which is not conducive to wound healing. , and cause unbearable pain to the patient. The hydrogel dressing has excellent physical and biocompatibility, sticks to the wound, does not adhere to the wound, does not destroy new tissue, and can kill a variety of bacteria and avoid wound infection. Compared with traditional dressings, hydrogel dressings can promote better wound heali...

Claims

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Application Information

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IPC IPC(8): A61L15/32A61L15/28A61L15/24A61L15/42A61L15/44C08J3/28C08J3/24C08J3/075
Inventor 林青卢亮
Owner 江西金思康药业有限公司
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