Preparation method of self-assembly polymer material with visible light and pH responsiveness

Abstract

The invention discloses a preparation method of a controllable micelle with a visible light and pH responsiveness, and belongs to the polymer field. The preparation method specifically comprises the following steps: subjecting polymerizable monomer dimethylaminoethyl methacrylate to carry out electron transfer and free radical polymerization reactions to polymerize polydimethylaminoethyl methacrylate, then grafting 3-bromoperylene onto the poly(dimethylaminoethyl methacrylate) so as to obtain an amphiphilic polymer with a visible light and pH responsiveness, and making the amphiphilic polymer into micelle with a visible light and pH responsiveness through a micellization process. The polymer micelle is stable at the room temperature, and can load hydrophobic molecules such as Nile red, and the like; the visible light irradiation and pH value can be adjusted to change the micelle morphology, and thus the loaded molecules are released from the micelle; the polymer micelle not only has a pH responsiveness, but also has a visible light responsiveness, and is a novel polymer micelle with a visible light and pH responsiveness. The self-assembly polymer material with a visible light and pH responsiveness and the preparation method thereof have a vast application aspect in the drug control-release field.

Description

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AI Technical Summary

Benefits of technology

This technology allows for creating small particles called microvesicles (MV) containing certain guests inside them by themselves forming tiny droplets when exposed to specific conditions such as acidity or UV rays. These minute objects have been shown to interact strongly between different types of chemical species like hydrogen bonds at room temperature without being harmful if they come into contact with living tissues. They also allow controlled releasing of these miniatures from aqueous environments through their own ability to break up over time due to environmental factors like pH levels.

Problems solved by technology

This patented technology describes how an amoφhydrophile polymer material called AMPS can create tiny particles that stick together like balls when exposed to specific conditions. These small particles act as a vehicle carrying various substances inside their cores. They allow these agents to diffuse freely within the surrounding liquid medium without losing their original structure. Additionally, they provide a way to control the amount released from the agent's own internal cavity during loading. Overall, this technology allows for precise controlled dosage deliveries overcomes issues associated with traditional methods involving dissolving/dispersible dyes.

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