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Expansion suppository of clotrimazole or clotrimazole salt and preparation method thereof

A technology of clotrimazole and expansible suppositories, which is applied in the field of vaginal suppositories, can solve the problems of easy-to-contaminate clothes, insufficient absorption, and difficult cleaning, and achieve the effects of avoiding secondary infection, simple preparation method, and few process steps

Active Publication Date: 2014-01-22
哈尔滨田美药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The following problems generally exist in the above-mentioned suppositories: 1. It is not easy to clean, and it is easy to contaminate clothes; 2. The contact surface between the active drug and the human body is small, resulting in insufficient absorption, and the best curative effect of the prescription is not exerted; medicine time is short

Method used

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  • Expansion suppository of clotrimazole or clotrimazole salt and preparation method thereof
  • Expansion suppository of clotrimazole or clotrimazole salt and preparation method thereof
  • Expansion suppository of clotrimazole or clotrimazole salt and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070]

[0071] Preparation:

[0072] a. Weigh semi-synthetic fatty acid glycerides and lanolin according to the prescription amount, and heat and melt in a water bath at 40°C;

[0073] b. Add clotrimazole under continuous stirring, and mix evenly to obtain a mixture;

[0074] c. The mixture in step b is poured into a plastic shaped suppository, inserted into a tampon, cooled and shaped to make a duckbill-shaped suppository.

Embodiment 2

[0076]

[0077] Preparation method: according to the method of Example 1, it is prepared into a bullet shape.

Embodiment 3

[0078] Embodiment 3 torpedo-shaped clotrimazole expansion plug

[0079]

[0080] Preparation method: according to the method of Example 1, a torpedo-shaped expansion plug is prepared.

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Abstract

The invention relates to an expansion suppository of clotrimazole or a clotrimazole salt. The expansion suppository is composed of clotrimazole or the clotrimazole salt, a lipid-soluble matrix and an expandable expansion carrier. The invention also relates to a preparation method of the expansion suppository. The provided expansion suppository of the clotrimazole or the clotrimazole salt adopts seven original-creation lead-edge technologies, wherein the addition of the expansion carrier applies six technologies including an 'one-time suppository filling integrated forming' technology, an 'inner core expansion coefficient control' technology, a 'human engineering suppository type' technology, a 'treatment-cleaning integration dosage form', a 'vaginal inner-attached administration' technology and a 'side leakage prevention suppository body design'; and poloxamer and a sustained release material of the expansion suppository apply a 'medicine long-acting layered release' technology. The expansion suppository of clotrimazole or the clotrimazole salt has the beneficial effects that the expansion suppository has high efficiency, long acting, safety and small side effects, prevents a medicine liquid from flowing outside, and has the efficacy of cleaning a vagina so as to prevent superinfection.

Description

[0001] This application is a divisional application of the parent application with the application number 201310182125.6, the application date is May 17, 2013, and the invention name is "clotrimazole or its salt expansion plug and its preparation method and detection method". technical field [0002] The invention belongs to the field of vaginal suppositories, and in particular relates to a clotrimazole or its salt expansion suppository, a preparation method and a detection method thereof. Background technique [0003] Clotrimazole, whose chemical name is 1-[(2-chlorophenyl)benzhydryl]-1H-imidazole, is soluble in absolute ethanol and acetone, and is almost insoluble in water. Its structural formula is as follows: [0004] [0005] Clotrimazole or its salt is an imidazole broad-spectrum antifungal drug, which has inhibitory effects on various fungi such as Candida and Candida. It mainly selectively interferes with the activity of fungal cytochrome P-450, thereby inhibiting...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/02A61K31/4174A61K47/34A61K47/24A61K47/32A61K47/38A61P31/10A61P15/02
Inventor 邱学良邱明世
Owner 哈尔滨田美药业股份有限公司