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A kind of preparation method of hydroxyapatite whisker

A hydroxyapatite and whisker technology, applied in the field of chemical and biological engineering materials, can solve the problems of low mechanical strength, high specific modulus, creep resistance and high temperature performance, and achieve simple reaction process, biological activity and degradation performance. Increased, length and aspect ratio controllable effects

Active Publication Date: 2016-06-08
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, studies have shown that the mechanical strength of hydroxyapatite is low, and compared with non-whiskers, whiskers have high specific strength, high specific modulus, better creep resistance and high temperature performance. Whisker materials rely on bridging, crack deflection, and pull-out effects to absorb energy and eliminate stress at the crack tip to enhance the mechanical properties of the material

Method used

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  • A kind of preparation method of hydroxyapatite whisker
  • A kind of preparation method of hydroxyapatite whisker
  • A kind of preparation method of hydroxyapatite whisker

Examples

Experimental program
Comparison scheme
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Embodiment approach 1

[0041] Implementation mode one: such as Figure 1~3 As shown in and 15, this embodiment relates to the preparation method of barium-doped hydroxyapatite whiskers:

[0042] (1) Prepare the mixture of calcium nitrate tetrahydrate, barium nitrate and diammonium hydrogen phosphate, concentrated nitric acid, sorbitol and hydroxyapatite crystals in a molar ratio of 1:1.1:15:0.2:0.4, and then mix the above ratio Calcium nitrate tetrahydrate, barium nitrate, concentrated nitric acid and diammonium hydrogen phosphate were added to distilled water and stirred until dissolved. The molar ratio of distilled water to diammonium hydrogen phosphate was 500:1. The mixture of barium nitrate and diammonium hydrogen phosphate has a molar ratio of metal ion to phosphorus of 0.3:1.

[0043] (2) Add concentrated nitric acid to the above mixed solution to adjust the pH to 2.5. After stirring for 10 minutes, add sorbitol and hydroxyapatite crystals according to the ratio described in step (1). Continue sti...

Embodiment approach 2

[0045] Implementation mode two: such as Figure 4~8 As shown, this embodiment relates to a method for preparing zinc-doped hydroxyapatite whiskers:

[0046] (1) Prepare the mixture of calcium nitrate tetrahydrate, zinc nitrate and diammonium hydrogen phosphate, concentrated nitric acid, sorbitol and hydroxyapatite crystals in a molar ratio of 1:2.2:5:0.4:0.1, and then mix the above ratio Calcium nitrate tetrahydrate, zinc nitrate, concentrated nitric acid and diammonium hydrogen phosphate are added to the distilled water and kept stirring until dissolved. The molar ratio of distilled water to soluble phosphorus salt is 50:1; the mixture of zinc nitrate and diammonium hydrogen phosphate is The molar ratio of metal ions to phosphorus is 0.001:1.

[0047] (2) Add concentrated nitric acid to the above mixed solution to adjust the pH to 1.5. After stirring for 15 minutes, add sorbitol and hydroxyapatite crystals according to the ratio described in step (1). Continue stirring for 15 minu...

Embodiment approach 3

[0049] Implementation mode three: such as Figure 4~8 As shown in and 16, this embodiment relates to the preparation method of magnesium-doped hydroxyapatite whiskers:

[0050] (1) Prepare the mixture of calcium nitrate tetrahydrate, magnesium nitrate and diammonium hydrogen phosphate, concentrated nitric acid, sorbitol and hydroxyapatite crystals in a molar ratio of 1:1.8:10:0.1:0.2, and then mix the above ratio Calcium nitrate tetrahydrate, magnesium nitrate, concentrated nitric acid and diammonium hydrogen phosphate are added to distilled water and kept stirring until dissolved. The molar ratio of distilled water to diammonium hydrogen phosphate is 5000:1; a mixture of magnesium nitrate and diammonium hydrogen phosphate The molar ratio of metal ions to phosphorus is 0.5:1.

[0051] (2) Add concentrated nitric acid to the above mixed solution to adjust the pH to 3.5. After stirring for 5 minutes, add sorbitol and hydroxyapatite crystals according to the ratio described in step (1...

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Abstract

The invention relates to a method for preparing hydroxyapatite whiskers, which belongs to the field of chemical and biological engineering materials. Add soluble calcium salts, metal salts, pH regulators and soluble phosphorus salts into distilled water and stir continuously until dissolved; add acidity regulators to the above mixed solution to adjust the pH to 1.5-3.5, stir for 5-15 minutes and follow Add template agent and hydroxyapatite seedlings in the ratio described in step (1), continue to stir for 5 to 15 minutes, then react in a water bath or under high pressure for 10 to 36 hours, and wash the reaction product with distilled water after the above reaction is completed. Then suction filter to obtain whisker filter cake, and finally dry or freeze to obtain hydroxyapatite whisker. The whiskers obtained by the method not only have excellent biocompatibility, bioactivity, good mechanical properties, etc., but also are safe and simple to operate, have stable length-to-diameter ratios and high yields.

Description

Technical field [0001] The invention relates to a preparation method of hydroxyapatite whiskers, belonging to the field of chemical and biological engineering materials. Background technique [0002] Clinically, bone repair and regeneration is a common and complex problem. Every year, millions of patients suffer from orthopedic diseases due to trauma, and many people die due to lack of ideal substitute materials. Hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 ), abbreviated as HA or HAP, has a similar chemical composition and structure to biological bone tissue, and has good biocompatibility. Due to the general form of HAP powder, synthetic materials such as HAP ceramics and calcium phosphate cement have lower Fracture toughness, therefore, limits its application in load-bearing bones. Hydroxyapatite is the main inorganic component in hard tissues. Due to its good biocompatibility and biological activity, it can guide bone growth and has a strong affinity with the matrix tissue. It is r...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C30B29/14C30B29/62C30B7/10
Inventor 陈庆华王端诚颜廷亭
Owner KUNMING UNIV OF SCI & TECH