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Molecules and methods for inhibition and detection of proteins

A protein and molecular technology, applied in chemical instruments and methods, peptides containing affinity tags, peptides containing His tags, etc.

Active Publication Date: 2014-01-29
VLAAMS INTERUNIVERSITAIR INST VOOR BIOTECHNOLOGIE VZW +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, at the microscopic level, the differences between these two types of aggregates are more subtle

Method used

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  • Molecules and methods for inhibition and detection of proteins
  • Molecules and methods for inhibition and detection of proteins
  • Molecules and methods for inhibition and detection of proteins

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 4

[0907] Example 4 illustrates the different ways in which the molecules of the invention can be used to detect proteins ranging from bacterial to human proteins, and how this can be applied to disease diagnosis by detecting biomarkers in complex samples.

Embodiment 5

[0908] Example 5 details the application for non-infectious diseases by showing the specific aggregation of two well-known receptor tyrosine kinases involved in cancer and AMD. It also demonstrates the concept that immune function can be modulated using the interferor molecules described herein.

[0909] Finally, Example 6 shows that the molecules of the invention can also be applied to achieve the downregulation of proteins in plants.

[0910] 1. Antifungal application

[0911] 1.1 Preface

[0912] Candida albicans forms part of the normal flora of humans and it grows on the mucosal surfaces of healthy individuals. In susceptible hosts, this fungal organism can cause disease with mucosal and hematogenous dissemination. For C. albicans to maintain and induce disease in a host, it must be able to adhere to biotic and abiotic surfaces, invade host cells, and acquire iron. The hyphae-specific surface protein Als3 of C. albicans is a member of the lectin-like sequence (Als...

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Abstract

The present application belongs to the field of functional peptides and more particularly to the field of controlled protein aggregation. The invention discloses molecules of a peptide structure as defined in the claims and methods of using such molecules for therapeutic applications and for diagnostic uses, as well as in other applications such as in the agbio field and in industrial biotechnology. The molecules can be used for curing and / or stabilizing infections such as bacterial,fungal and viral diseases, but are also useful in non-infectious human and veterinary diseases. The molecules can also be used for the detection of protein biomarkers and for the prognosis and diagnosis of a variety of diseases.

Description

field of invention [0001] This application is in the field of functional peptides and more specifically in the field of controlled protein aggregation. The present invention discloses molecules of peptide structure as defined in the claims, and methods of using such molecules in therapeutic and diagnostic applications, as well as other applications such as in the field of agricultural biology (agbio) and industrial biotechnology. The molecules of the invention can be used to treat and / or stabilize infections such as bacterial, fungal and viral diseases, as well as non-infectious human and veterinary diseases. The molecules of the invention can also be used to detect protein biomarkers and in the prognosis and diagnosis of various diseases. Background technique [0002] Protein aggregation results from protein misfolding and subsequent aggregation in insoluble aggregates. Protein aggregation is essentially a self-association process in which many identical protein molecules...

Claims

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Application Information

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IPC IPC(8): A61L27/00C07K14/00A61L31/08A61L31/16C07K14/40
CPCA61L2300/404A61L2300/25C07K2319/42C07K2319/43C07K2319/21C07K14/40A61L31/16A61L29/16A61L27/00A61L31/08A61P27/02A61P29/00A61P31/04A61P31/10A61P31/12A61P35/00
Inventor J·希姆科维兹F·鲁索
Owner VLAAMS INTERUNIVERSITAIR INST VOOR BIOTECHNOLOGIE VZW
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