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Pharmaceutical composition for bowel preparation

An intestinal preparation and composition technology, which is applied in the directions of drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve problems such as poor intestinal cleaning, poor taste of polyethylene glycol and sodium sulfate, and increased concentration, etc. question

Active Publication Date: 2014-02-05
重庆药归人生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, the concentration of polyethylene glycol and sodium sulfate increases, making it difficult to obtain a good taste
[0007] Based on the above, the dosage of polyethylene glycol electrolyte intestinal preparation drug polyethylene glycol is 200-480g polyethylene glycol, sodium sulfate 15g-23g, need 2-4 water to dissolve, polyethylene glycol and sodium sulfate taste bad , the patient needs to endure bad taste and poor compliance when taking a solution with a maximum volume of 4L
Patients often have adverse reactions such as nausea and vomiting, so reduce or stop using it, resulting in poor intestinal cleansing or failure, affecting the examination of the disease

Method used

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  • Pharmaceutical composition for bowel preparation
  • Pharmaceutical composition for bowel preparation
  • Pharmaceutical composition for bowel preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-4

[0043] Embodiment 1 and embodiment 4 add water to 100ml, embodiment 2, embodiment 3 and comparative example add water to 200ml. 10 dogs, with an average body weight of 12.5kg, were randomly divided into 5 groups, each group was cross-administered sequentially, the compositions of Example 1, Example 2, Example 3, Example 4 and Comparative Example 1, and the washing period for 5 days. Within 24 hours after taking it, the animals were fed with 50m of drinking water every hour.

[0044]

[0045] Comparative example is that the consumption of PEG3350 and sodium sulfate is that the consumption of PEG3350 and sodium sulfate of Klean Prep is converted according to the specific surface area of ​​people and Beagle dogs, and the conversion formula is Beagle dog consumption=1.88 * human body consumption / 60 (kg) * 12.5kg .

[0046]

[0047] Check the weight of the defecation within 24 hours, the results are shown in the table below.

[0048]

[0049] The above research results show...

example 9

[0059]

[0060] Preparation process: Dissolve sodium picosulfate, sodium saccharin, cyclamate, and citric acid in an appropriate amount of distilled water, spray into polyethylene glycol 3350 in a fluidized bed, dry, add essence, mix evenly, and pack into 50.71g / bag. Each bag can be dissolved in 250ml of water for patients to use, one intestinal preparation can be taken twice, one bag each time.

Embodiment 10

[0062]

[0063] Dissolve sodium picosulfate in appropriate amount of distilled water, spray into sodium bicarbonate in a fluidized bed, and dry. Add polyethylene glycol 3350, potassium chloride, sodium chloride, sodium saccharin, citric acid and essence, mix well, and pack into 104.2g / bag. The composition can be dissolved in 500-1000ml of water for patient use.

[0064]

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PUM

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Abstract

The invention belongs to the field of pharmacy, and relates to a pharmaceutical composition for bowel preparation of mammal. The pharmaceutical composition is characterized by comprising 20 to 200g of polyethylene glycol and 2 to 20mg of picosulfate or pharmaceutically acceptable salt thereof.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a pharmaceutical composition for cleaning the intestines of mammals, which is characterized in that the composition contains polyethylene glycol and picosulfuric acid or a pharmaceutically acceptable salt thereof, wherein polyethylene glycol The amount of alcohol is 20g-200g, and the amount of picosulfuric acid or its pharmaceutically acceptable salt is 2mg-20mg. Background technique [0002] Bowel preparation is an essential step in colonoscopy, and the effect of bowel preparation directly affects the quality and accuracy of colonoscopy. At the same time, bowel preparation is also a necessary step for abdominal surgery, pelvic surgery, and thoracic surgery. [0003] At present, commonly used drugs for intestinal preparation include sodium phosphate oral solution, polyethylene glycol electrolyte powder, etc. Sodium Phosphate Oral Solution is easily accepted by patients ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/765A61P1/10A61K31/4402
Inventor 王显著
Owner 重庆药归人生物医药科技有限公司
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