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Combination medicine, preparation method and application of Qingjue liver-protecting and eyesight-improving drug pair

A drug and drug pairing technology, which is applied in the field of Qingjue liver protection and eyesight drug combination drug preparation, can solve the problems of increasing patients' suffering and increasing patients' economic burden, and achieve good activity and good effect

Active Publication Date: 2016-08-17
CHONGQING ACAD OF CHINESE MATERIA MEDICA +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, some serious complications may occur in cataract surgery, which will not only increase the pain of the patient, but also increase the financial burden of the patient

Method used

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  • Combination medicine, preparation method and application of Qingjue liver-protecting and eyesight-improving drug pair
  • Combination medicine, preparation method and application of Qingjue liver-protecting and eyesight-improving drug pair
  • Combination medicine, preparation method and application of Qingjue liver-protecting and eyesight-improving drug pair

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] The impact of different solvent extractions of embodiment 1 on active ingredient

[0013] Weigh 3 groups of Semen Cassiae and Folium Folium with a weight ratio of 1:1, use 70% ethanol, ethyl acetate and water as solvents respectively, and extract with reflux method, the amount of solvent is 7 times of the weight of medicinal materials, the extracted The number of times is 2 times, 1 hour each time; the extracts of each group are combined and recovered, and the solvent is recovered to make a dry paste, and the alcohol extraction group, ethyl acetate extraction group and water extraction group are prepared; the total solid yield of each group, Chrysophanol content and indirubin content are specifically shown in Table 1.

[0014] Table 1 Extraction process orthogonal experiment results

[0015] group

Embodiment 2

[0016] Example 2 Investigation of Conditions for Using Ethyl Acetate to Extract Folium Folium and Semen Cassiae Mixture

[0017] In this embodiment, the determination of the content of chrysophanol, the content of indirubin and the total solid yield in the extract is taken as indicators, and the orthogonal test method is adopted. The experimental design is shown in Table 2; the extraction process conditions of Semen Cassiae are preferred. According to the results of the preliminary test, select the factors and levels that affect the extraction effect, as shown in Table 3.

[0018] Table 2 Extraction process factor level table

[0019]

[0020] Preparation of the sample solution: Weigh Semen Cassiae and Folium Folium medicinal materials with a weight ratio of 2:1, according to the experimental method of the test column number in Table 3, use ethyl acetate as the solvent, respectively reflux extraction, filter, and concentrate to a constant volume. 250mL, set aside for later...

Embodiment 3

[0026] The preparation of embodiment 3 experimental samples

[0027] Weigh Semen Cassiae and Folium Folium with a weight ratio of 10:1, according to the optimal method in the examples, use ethyl acetate as a solvent, extract and combine the extracts, recover and make a dry paste, and prepare the experimental group I;

[0028] Weigh the Semen Cassiae and Folium Folium medicinal materials with a weight ratio of 1:10, according to the best method in the examples, use ethyl acetate as a solvent, extract and combine the extracts, recover and make a dry paste, and prepare the experimental group II;

[0029] Weigh Semen Cassiae and Folium Folium with a weight ratio of 3:1, according to the optimal method in the examples, use ethyl acetate as a solvent, extract and combine the extracts, recover and make a dry paste, and prepare the experimental group III;

[0030] The Semen Cassiae medicinal material was weighed, and according to the optimal method in the examples, ethyl acetate was u...

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Abstract

The invention provides a combination medicine of Qingcai protecting the liver and improving eyesight. The medicine combination medicine is the extract obtained by extracting two kinds of medicinal materials, Cassia Folium and Folium Folium; the preparation method is to mix Folium Folium and Folium Folium The medicinal material is extracted, the solvent is ethyl acetate, and the amount of the solvent is 7 times the weight of the medicinal material, and the extraction is performed twice, each time for 1.0h; The extracts of the two single medicinal materials are more active, and they have good activity in protecting the liver and improving eyesight, and even treating cataracts.

Description

technical field [0001] The present invention relates to a kind of traditional Chinese medicine composition, more specifically relates to a kind of combination medicine of Chinese medicine for protecting liver and improving eyesight, preparation method and application thereof. technical background [0002] Cataract is the leading cause of blindness in my country, and its only effective treatment is surgery. However, some serious complications may occur in cataract surgery, which will not only increase the pain of the patient, but also increase the financial burden of the patient. Therefore, it is very important to prevent or treat cataract with drugs in the early stage. Because most cataracts develop slowly and require long-term medication, Chinese herbal medicines are pure natural medicines with few side effects and are suitable for long-term use. Therefore, the development of effective prescriptions for Chinese herbal medicines has become one of the hot spots in the resear...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/855A61K36/704A61K36/482A61P27/12A61P27/02
Inventor 杨大坚陈新滋陈士林卞兆祥吕爱平徐宏喜陈国庆张毅
Owner CHONGQING ACAD OF CHINESE MATERIA MEDICA
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