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Method for preparing high-purity scutellarein

A technology of scutellarin and breviscapine aglycone, which is applied in the field of drug synthesis, can solve the problems of difficult industrialized production, low purity of scutellarin aglycone, etc., and achieves the effects of simple method, high purity, and cheap reagents.

Active Publication Date: 2014-02-12
KPC PHARM INC
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Problems solved by technology

[0008] In order to solve the problem of low purity of scutellarin aglycone and difficulty in industrial production in the prior art, the present invention provides a new method for preparing scutellarin aglycon that is simple, high in yield, high in purity and capable of industrial production

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  • Method for preparing high-purity scutellarein
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  • Method for preparing high-purity scutellarein

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Embodiment Construction

[0028] The invention discloses a method for preparing scutellarin aglycone, and those skilled in the art can learn from the content of this article and appropriately improve the process parameters to realize it. In particular, it should be pointed out that all similar replacements and modifications are obvious to those skilled in the art, and they are all considered to be included in the present invention. The method of the present invention has been described through preferred embodiments, and relevant personnel can obviously make changes or appropriate changes and combinations to the methods and applications described herein without departing from the content, spirit and scope of the present invention to realize and apply the present invention. Invent technology.

[0029] In order to enable those skilled in the art to better understand the technical solutions of the present invention, the present invention will be further described in detail below in conjunction with specifi...

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Abstract

The invention relates to pharmacy field and discloses a preparation method for high-purity scutellarein. The method employs 4',5,6,7-tetramethoxyflavone as the raw material which is subjected to demethylation, acylation and hydrolysis for preparation of the high-purity scutellarein, and the obtained compound, which is confirmed by nuclear magnetic resonance and high efficiency liquid phase, is identify with scutellarein extracted from plants The preparation method provided by the invention has the characteristics that the synthesis cost is low, the synthetic route is short, the reaction yield is high, the product is easy to purify, the industrial production is can be realized, and the like; and the preparation method has good industrial application prospect.

Description

technical field [0001] The invention relates to the field of drug synthesis, in particular to a method for preparing scutellarin aglycon. Background technique [0002] Scutellarein, also known as scutellarein, scutellarein, scutellarein, CAS: 529-53-3, molecular formula C 15 h 10 o 6 , molecular weight: 286.24), its structural formula is shown in formula (I): [0003] [0004] Breviscapine has a very clear curative effect on ischemic cerebrovascular disease, coronary heart disease, hypertension, cerebral hemorrhage, cerebral thrombosis, cerebral embolism multiple neuritis, chronic arachnoiditis and its sequelae. Scutellarin aglycon exerts medicinal effect. The latest pharmacological studies have shown that the active metabolites of scutellarin in vivo are scutellarin aglycone and its glucuronidation, sulfation, methylation and other conjugates. [0005] Scutellarin can be synthesized through acylation, hydroxyl protection, glycosidation, and deacylation of scutellari...

Claims

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Application Information

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IPC IPC(8): C07D311/30
CPCC07D311/30
Inventor 张伟李鹏辉杨兆祥张雄波朱海贝王珺陈锦锌
Owner KPC PHARM INC
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