Water soluble ethopabate composition and compound composition thereof

A technology of ethoxyn amidine and compound composition, which is applied in the field of water-soluble ethoxyn amidine compositions and compound compositions thereof, and can solve the problems such as difficult mixing of premixes, affecting treatment effect and the like

Active Publication Date: 2014-03-12
LUOYANG HUIZHONG ANIMAL MEDICINE
View PDF2 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The invention provides a water-soluble ethopabate composition, which solves the problem of pharmaceutical compositions in which ethopabate is insoluble in water. Further, the invention provides a water-soluble ethopabate comp

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Water soluble ethopabate composition and compound composition thereof
  • Water soluble ethopabate composition and compound composition thereof
  • Water soluble ethopabate composition and compound composition thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1: Pulverization of ethopabate

[0026] Crushing equipment: QYF-2600 jet mill Kunshan Miyou Machinery Manufacturing Co., Ltd.

[0027] Crushed sample source: ethopabate (Fuyang Chengxing Chemical Auxiliary Co., Ltd. batch number: 20120302)

[0028] Set the pressure of the air compressor to 0.4Mpa, the speed of the classifying wheel to 7200 rpm, the crushing pressure of the main air valve to 0.8MPa, and the pressure to the blowback valve to 0.4-0.6MPa. The crushing amount is 5-10g / sec. Qualified ethopabate can be obtained after crushing.

[0029] Particle size determination of ethopabate micropowder:

[0030] Determination method: "Pharmacopoeia of the People's Republic of China" appendix particle size determination method, method 1, microscope determination method.

[0031] A. Calibration of eyepiece micrometer

[0032] The size of the powder particle size is measured by the eyepiece micrometer (referred to as the eyepiece micrometer) placed in the eyepiece...

Embodiment 2

[0043] Embodiment 2: the impact of ultrafine grinding on the solubility of ethopabate

[0044] 1. Grinding of ethopabate

[0045] The ethopabate provided in the present invention is pulverized, and its particle size is ≤20 μm.

[0046] Crushing equipment: QYF-2600 jet mill Kunshan Miyou Machinery Manufacturing Co., Ltd.

[0047] Crushed sample source: ethopabate (Fuyang Chengxing Chemical Auxiliary Co., Ltd. batch number: 20120302)

[0048] Set the pressure of the air compressor to 0.4Mpa, the speed of the classifying wheel to 7200 rpm, the crushing pressure of the main air valve to 0.8MPa, and the pressure to the blowback valve to 0.4-0.6MPa. The crushing amount is 5-10g / sec. Qualified ethopabate can be obtained after crushing.

[0049] 2. Comparison of the dissolution rate of ethopabate containing different particle sizes in purified water

[0050] Weigh 0.1 g of ethopabate (Fuyang Chengxing Chemical Auxiliary Co., Ltd. batch number: 20120302) with different particle si...

Embodiment 3

[0064] Preparation of soluble compound composition containing ethopabate:

[0065]

[0066] Preparation method: Weigh 0.5 g of crushed ethopabate and 10.0 g of sodium carbonate, mix well, then add amprolium hydrochloride 10.0 g, sulfaquinoxaline sodium 6.0 g, mix well, add glucose 73.5 g and mix uniformly to obtain a soluble powder compound composition.

[0067] Solubility determination of ethopabate in the soluble compound composition containing ethopabate:

[0068] Take 100g of the above-prepared soluble compound composition and place it in 100ml of purified water at 25±2°C, place it at room temperature for 2 hours, filter the solution, and take the filtrate. Determination of the method under the item, the content of ethopabate in the HPLC assay solution.

[0069]

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Particle sizeaaaaaaaaaa
Particle sizeaaaaaaaaaa
The average particle sizeaaaaaaaaaa
Login to view more

Abstract

The invention provides a water soluble ethopabate composition and a compound composition thereof. The composition and the compound composition thereof can be used to manufacture drugs for preventing and treating coccidiosis. The drugs can be taken through drinking water, so the problem that a premix is hard to mix uniformly in the feed and the curative effect is affected is effectively solved.

Description

technical field [0001] The invention belongs to the field of veterinary medicine, and in particular relates to a water-soluble ethopabate composition and a compound composition thereof. Background technique [0002] With the development of my country's animal husbandry industry, the harm of chicken coccidiosis is becoming more and more serious. Worldwide economic losses due to coccidiosis are approximately US$ 2 billion. According to reports, there are more than 40 kinds of anticoccidial drugs, but most of them develop drug resistance after several years of use. Therefore, the prevention and treatment of coccidiosis has become a common problem in the breeding industry. The onset of coccidiosis is characterized by increased drinking water and reduced food intake, so water-soluble drugs can exert a better therapeutic effect. [0003] Ethoxylate is a white or off-white powder; odorless or almost odorless. It is very slightly soluble in water, and the solubility in water is ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/245A61K31/635A61P33/02A61K31/506
Inventor 张许科刘兴金张晓会
Owner LUOYANG HUIZHONG ANIMAL MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap