Polysaccharide composition and application, pharmaceutical preparation containing it

A technology for pharmaceutical preparations and compositions, applied in the fields of polysaccharide compositions and applications, and pharmaceutical preparations containing them, can solve problems such as poor hypoglycemic effect, and achieve the effects of enhancing human immune function, having no toxic side effects, and reducing blood sugar.

Active Publication Date: 2015-12-30
HILL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the defects of polysaccharide biological activity and poor blood sugar lowering effect in the prior art, the present invention provides a polysaccharide composition with high biological activity and good blood sugar lowering effect and its application, and a pharmaceutical preparation containing it

Method used

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  • Polysaccharide composition and application, pharmaceutical preparation containing it
  • Polysaccharide composition and application, pharmaceutical preparation containing it
  • Polysaccharide composition and application, pharmaceutical preparation containing it

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 3

[0044] The mulberry leaf polysaccharide and bitter melon polysaccharide used in embodiment 3 are made by following method:

[0045] Preparation method 2: Mix mulberry leaves or bitter gourd with water at a mass-volume ratio of 1g / 20mL, then extract at 100°C for 1 hour each time, extract twice, combine and filter, concentrate in vacuum to a relative density of 1.25, and add the concentrate to a volume percentage of 3 times the volume 95% ethanol aqueous solution was used for ethanol precipitation, and the precipitate was collected and dried.

[0046] Polygonatum polysaccharides and Lycium barbarum polysaccharides used in embodiments 1 to 3 are prepared by the following methods successively:

[0047]Preparation method 1: first pretreat Polygonatum or Lycium barbarum: add ethanol aqueous solution according to the ratio of solid to liquid 1:10 (mass g of Polygonatum or Lycium barbarum: volume mL of ethanol), soak for 12 hours, filter, and dry at 60°C.

[0048] After pretreatment,...

Embodiment 1

[0053] Capsule preparation

[0054] prescription:

[0055]

[0056] Preparation method: Weigh mulberry leaf polysaccharide, balsam pear polysaccharide, Polygonatum polysaccharide and Lycium barbarum polysaccharide respectively according to the above weight parts, mix them evenly, pack them into capsules, and obtain.

Embodiment 2

[0058] tablet preparation

[0059] prescription:

[0060]

[0061] Preparation method: Weigh mulberry leaf polysaccharide, balsam pear polysaccharide, Polygonatum polysaccharide, Lycium barbarum polysaccharide respectively according to the above weight parts, mix well, add 5% microcrystalline cellulose and 4% dextrin and other auxiliary materials, mix well, granulate, dry, Add 2% sodium carboxymethyl starch and 0.1% magnesium stearate, mix well, and press to make 1000 tablets. The above percentages are the mass proportions of the above pharmaceutical excipients in the polysaccharide composition.

[0062] Example 3

[0063] Oral solution preparation

[0064] prescription:

[0065]

[0066] Preparation method: Weigh mulberry leaf polysaccharide, balsam pear polysaccharide, sealwort polysaccharide and wolfberry polysaccharide according to the above parts by weight, mix evenly, add an appropriate amount of solubilizer, dissolve in water, add 5% erythritol, filter, steril...

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Abstract

The invention provides a polysaccharide composition, application and a medicinal preparation containing the same. The polysaccharide composition comprises the following substances in parts by weight: 20-90 parts of mulberry leaf polysaccharide, 20-90 parts of balsam pear polysaccharide, 10-80 parts of polygonatum rhizome polysaccharide and 10-40 parts of matrimony vine polysaccharide. The product has blood sugar reducing effect, is capable of maintaining islet cells, is helpful for enhancing human body immunity, and especially is helpful for enhancing the self resistant and regulating capabilities of weak diabetes patients; and the various polysaccharide compositions have the synergic effect, so that a diabetes pathological position is affected by multiple targets, and the product has obvious blood sugar reducing effect.

Description

technical field [0001] The invention relates to a polysaccharide composition and its application, and a pharmaceutical preparation containing it. Background technique [0002] Diabetes mellitus (DM) is a common endocrine and metabolic disorder caused by relative or absolute insufficiency of insulin secretion in the body, decreased sensitivity of target cells to insulin, or structural defects in insulin itself. Diabetes persists for life, and its complications threaten human health. According to the latest "Journal of the American Medical Association", at present, Chinese diabetic patients have reached 114 million, accounting for about one-third of the total number of diabetic patients in the world. The number of patients is still increasing. [0003] Proteins, genes, and polysaccharides are the three major fields of life sciences. The research on the first two has achieved great results in the 20th century, and the research and development of polysaccharides, which can make...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/715C08B37/00A61P3/10A61P13/12A61P9/10A61P17/00
Inventor 邓义德易跃能陈锋肖满意刘湘荣
Owner HILL PHARMA
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