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Muscle relaxing pills and preparation method thereof

A technology of relaxing tendon pills and vinegar preparation, which is applied in the directions of pill delivery, pharmaceutical formulations, and medical preparations containing active ingredients, etc., and can solve the problems of affecting the curative effect, slow disintegration, and insufficient dissolution of active ingredients.

Active Publication Date: 2014-04-02
黑龙江参鸽药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation methods of the Chinese Pharmacopoeia are all raw powder used as medicine, the active ingredients cannot be fully dissolved, the disintegration is slow, and the bioavailability is low, which affects the curative effect

Method used

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  • Muscle relaxing pills and preparation method thereof
  • Muscle relaxing pills and preparation method thereof
  • Muscle relaxing pills and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Take Nuxychia 1150g, Ephedra 800g, Duhuo 60g, Notopterygium 60g, Guizhi 60g, Licorice 60g, Qiannianjian 60g, Achyranthes bidentata 60g, Vinegar-made Frankincense 60g, Papaya 60g, Vinegar-made Myrrh 60g, Fangfeng 60g, Salt-made Eucommia 30g, 60g of maple bark, 30g of Dipsacus, crushed into 40-mesh coarse powder, put in a circulating ultrasonic extractor, add 26700g of water, 1g of germanium powder, 1g of Tween 60, select ultrasonic frequency of 50KHz, and extract for 30 minutes at a pressure of 0.3Mpa. Filter through an 80-mesh sieve to obtain the extract; take the extract and put it in a jet spray dryer, control the inlet air temperature at 40°C, the pressure at 0.02Mpa, and the flow rate at 400 meters per second to obtain nano-extract powder; take the extract powder and add 500g polyethylene glycol Mix with alcohol 4000, control material temperature 70°C, condensing temperature 2°C, drop distance 2.0cm, drop speed 20 drops per minute, drop into liquid paraffin, take out...

specific Embodiment 2

[0038] Take Nuxychia 1150g, Ephedra 800g, Duhuo 60g, Notopterygium 60g, Guizhi 60g, Licorice 60g, Qiannianjian 60g, Achyranthes bidentata 60g, Vinegar-made Frankincense 60g, Papaya 60g, Vinegar-made Myrrh 60g, Fangfeng 60g, Salt-made Eucommia 30g, 60g of maple bark, 30g of Dipsacus, crushed into 40-mesh coarse powder, put in a circulating ultrasonic extractor, add 26700g of water, 3g of germanium powder, 3g of Tween 60, select ultrasonic frequency 60KHz, and extract for 30 minutes at a pressure of 0.5 Mpa. Filter through an 80-mesh sieve to obtain the extract; take the extract and put it in a jet spray dryer, control the inlet air temperature at 50°C, the pressure at 0.04 Mpa, and the flow rate at 600 meters per second to obtain nano-extract powder; take the extract powder and add 500g polyethylene glycol Mix with alcohol 4000, control the material temperature at 80°C, condensing temperature at 4°C, drop distance at 4.0cm, drop rate at 30 drops per minute, drop into liquid para...

Embodiment 3

[0040] Take Nuxychia 1150g, Ephedra 800g, Duhuo 60g, Notopterygium 60g, Guizhi 60g, Licorice 60g, Qiannianjian 60g, Achyranthes bidentata 60g, Vinegar-made Frankincense 60g, Papaya 60g, Vinegar-made Myrrh 60g, Fangfeng 60g, Salt-made Eucommia 30g, 60g of maple bark, 30g of Dipsacus, crushed into a 40-mesh coarse powder, put in a circulating ultrasonic extractor, add 26700g of water, 2g of germanium powder, 2g of Tween 60, select ultrasonic frequency 55KHz, and extract for 30 minutes at a pressure of 0.4Mpa. Filter through an 80-mesh sieve to obtain the extract; take the extract and put it in a jet spray dryer, control the inlet air temperature at 45°C, the pressure at 0.03Mpa, and the flow rate at 500 meters per second to obtain nano-extract powder; take the extract and add 500g polyethylene glycol Mix with alcohol 4000, control the temperature of the material at 75°C, the condensation temperature at 3°C, the drop distance at 3.0cm, the drop rate at 25 drops per minute, drop in...

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Abstract

The invention discloses muscle relaxing pills and a preparation method thereof. The preparation method is characterized by comprising the following steps: crushing nux vomica, ephedra, radix angelicae pubescentis, notopterygium root, cassia twig, liquorice, obscured homalomena rhizome, radix achyranthis bidentatae, vinegar-processed frankincense, pawpaw, vinegar-processed myrrh, Chinese parsnip root, salted Eucommia ulmoides, anisetree bark and himalayan teasel root into coarse powder; placing the coarse powder into a circulating ultrasonic extractor; adding water, germanium powder and tween 60; performing ultrasonic extraction; performing jet spray drying to prepare nanometer extracting powder; adding polyethylene glycol 4000 and adding into liquid paraffin dropwise to prepare the muscle relaxing pills. The muscle relaxing pills are used for treating rheumatic arthritis; the curative effect is obviously more excellent than that of the commercially available muscle relaxing pills; an excellent effect is achieved.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a Shujin pill and a preparation method thereof. Background technique [0002] Shujin Wan, a variety in the Chinese Pharmacopoeia, has the effects of expelling wind and dampness, relaxing tendons and activating blood circulation. It is commonly used clinically to treat wind-cold-damp arthralgia, numbness of limbs, pain in muscles and bones, and difficulty in walking. The indication is rheumatoid arthritis. However, the preparation methods of the Chinese Pharmacopoeia are all raw powder used as medicine, the active ingredients cannot be fully dissolved, the disintegration is slow, and the bioavailability is low, which affects the curative effect. Contents of the invention [0003] In order to overcome the above disadvantages, the present invention provides a Shujin pill with complete extraction of active ingredients and high bioavailability and a preparation method th...

Claims

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Application Information

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IPC IPC(8): A61K36/888A61K9/20A61P29/00
Inventor 赵业辉
Owner 黑龙江参鸽药业有限公司