Anti-human papilloma virus L1 protein antibody, and coding gene and application thereof

An anti-human papilloma and L1 protein technology, applied in the field of anti-human papillomavirus L1 protein antibody and its coding gene and application field, can solve the problem of uncontrolled proliferation of epithelial cells and achieve high affinity effect
CN103694347BActive Publication Date: 2015-06-17HANGZHOU DALTON BIOSCI
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Patents(China)
Current Assignee / Owner
HANGZHOU DALTON BIOSCI
Publication Date
2015-06-17

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Abstract

The invention discloses an anti-human papilloma virus L1 protein antibody, and a coding gene and application thereof. The anti-human papilloma virus L1 protein antibody comprises a heavy chain variable region and a light chain variable region. The anti-human papilloma virus L1 protein antibody is characterized in that amino acid sequences of three hypervariable regions CDRH1, CDRH2 and CDRH3 of the heavy chain variable region are respectively disclosed as SEQ ID NO.5-7; and amino acid sequences of three hypervariable regions CDRL1, CDRL2 and CDRL3 of the light chain variable region are respectively disclosed as SEQ ID NO.8-10. The invention also discloses application of the anti-human papilloma virus L1 protein antibody in preparing reagents and medicines for detecting, preventing and treating human papilloma virus related diseases. The anti-human papilloma virus L1 protein antibody has high affinity with human papilloma virus L1 protein, and can be used for detecting and treating diseases of the human body.
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Description

technical field

[0001] The invention belongs to the technical field of genetic engineering, and in particular relates to an anti-human papillomavirus L1 protein antibody and its coding gene and application. Background technique

[0002] Human papillomavirus (HPV) is a species-specific epitheliophilic virus, which is a small DNA virus with double-stranded closed circle. The HPV virus consists of a coat of protein capsid and a double-stranded circular DNA core wrapped around it. The protein capsid consists of a major capsid protein (L1) and a minor capsid protein (L2). In 1949, Strauss first observed HPV particles under the electron microscope, which were spherical, 20-hedral symmetry, and about 45-55nm in diameter.

[0003] The genome of HPV comprises approximately 8000 base pairs. The HPV genome includes 8 early open reading frames (Open Reading Frame, referred to as ORF) (namely E1--E8), 2 late reading frames (ORF) and 1 non-coding long control region. In the early open...

Claims

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