Slow-release composition for improving immunity
A sustained-release composition and immunity technology, applied in the field of sustained-release compositions for improving immunity
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specific Embodiment 1
[0029] Arginine 10mg
[0030] Psyllium Extract 10mg
[0031] Rhodiola rosea polysaccharide 10mg
[0032] Hypromellose 150mg
[0033] Microcrystalline Cellulose 20mg
[0035] Mix the components of the sustained-release composition and the excipients except magnesium stearate evenly, make soft materials with 70% ethanol, granulate with 16 mesh, dry at 50°C, granulate with 16 mesh, and add magnesium stearate; The extended-release tablets are prepared on a tablet machine.
[0036] A sustained-release composition for improving immunity, consisting of
specific Embodiment 2
[0037] Arginine 15mg
[0038] Psyllium Extract 15mg
[0039] Rhodiola rosea polysaccharide 15mg
[0040] Hypromellose 150mg
[0041] Microcrystalline Cellulose 40mg
[0043] Mix the components of the sustained-release composition and the excipients except magnesium stearate evenly, make soft materials with 70% ethanol, granulate with 16 mesh, dry at 50°C, granulate with 16 mesh, and add magnesium stearate; The extended-release tablets are prepared on a tablet machine.
[0044] Toxicology research
specific Embodiment 3
[0045] According to the "Technical Guidelines for Acute Toxicity Research of Traditional Chinese Medicine and Natural Medicines", the acute toxicity study was carried out. Kunming mice were used, half male and half male. Before the experiment, they were fasted for 12 hours, and the mice in the test group were given the solution according to the product of Example 2 with the maximum dosage, once in the morning and evening; the mice in the control group were given the same amount of normal saline. The body weight, diet, appearance, behavior, secretion, excretion, poisoning and death of mice in each group were observed for 14 consecutive days. The results showed that the maximum dose of 273.1g / Kg administered to mice twice a day was 273.1g / Kg, equivalent to 90 times the daily oral dose of an adult, and the mice had no symptoms of acute toxicity and no lesions in tissues and organs, indicating that The product of the invention has good safety and low toxic and side effects.
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