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Anti-tumor sustained-release composition

A slow-release composition and anti-tumor technology, which is applied in the direction of anti-tumor drugs, drug combinations, plant raw materials, etc., to achieve the effect of improving extraction efficiency

Inactive Publication Date: 2014-04-23
崔铠
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the application of anti-tumor has not been reported. Therefore, the present invention relates to the use of anti-tumor slow-release products of stinky psyllium, so as to do preliminary exploration for the industrial development of stinky psyllium

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment 1

[0028] An anti-tumor sustained-release composition, consisting of

[0029] Egg Ginseng Extract 10mg

[0030] Psyllium Extract 2.5mg

[0031] Hypromellose 150mg

[0032] Microcrystalline Cellulose 20mg

[0033] Magnesium Stearate 3mg

[0034] Mix the components of the sustained-release composition and the excipients except magnesium stearate evenly, make soft materials with 70% ethanol, granulate with 16 mesh, dry at 50°C, granulate with 16 mesh, and add magnesium stearate; The extended-release tablets are prepared on a tablet machine.

specific Embodiment 2

[0035] An anti-tumor sustained-release composition, consisting of

[0036] Egg Ginseng Extract 20mg

[0037] Psyllium Extract 4mg

[0038] Hypromellose 100mg

[0039] Microcrystalline Cellulose 40mg

[0040] Magnesium Stearate 5mg

[0041] Mix the components of the sustained-release composition and the excipients except magnesium stearate evenly, make soft materials with 70% ethanol, granulate with 16 mesh, dry at 50°C, granulate with 16 mesh, and add magnesium stearate; The extended-release tablets are prepared on a tablet machine.

specific Embodiment 3

[0042] Toxicology research

[0043] According to the "Technical Guidelines for Acute Toxicity Research of Traditional Chinese Medicine and Natural Medicines", the acute toxicity study was carried out. Kunming mice were used, half male and half male. Before the experiment, they were fasted for 12 hours, and the mice in the test group were given the solution according to the product of Example 2 with the maximum dosage, once in the morning and evening; the mice in the control group were given the same amount of normal saline. The body weight, diet, appearance, behavior, secretion, excretion, poisoning and death of mice in each group were observed for 14 consecutive days. The results showed that the maximum dose of 186g / Kg administered twice a day to mice was 186g / Kg, equivalent to 90 times the daily oral dose of an adult, and the mice had no symptoms of acute toxicity and no pathological changes in tissues and organs. The invented product has good safety and low toxic and s...

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PUM

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Abstract

The invention relates to an anti-tumor sustained-release composition. The anti-tumor sustained-release composition contains codonopsis convolvulacea extracts, pulicaria insignis extracts, and auxiliary sustained-release materials.

Description

technical field [0001] The invention relates to the field of health food, in particular to an anti-tumor slow-release composition. Background technique [0002] Stink psyllium ( Pu licaria insignis Drumm. ex Dunn ) is Compositae ( Compositae ) Psyllium ( Pulicaria ) plants, which are produced in Gyantse, Lhasa and Tsariba at an altitude of more than 4000 m in southern Tibet, and are unique medicinal plants in Tibet. The flowers of this plant are used medicinally in Tibet, named "Ming.chen.serpo", which has antipyretic and analgesic effects. The plants of this genus have the effect of repelling fleas, and the active ingredients of the insect repellent may be sesquiterpenoids. However, there is no anti-tumor application product of stinky psyllium at present. [0003] Codonopsis convol v ulacea Kurz is the root of Codonopsis convol v ulacea Kurz, which is a perennial winding herb. Distributed in Sichuan, Guizhou, Yunnan and other places. It has the functions of invigora...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/344A61P35/00
Inventor 崔铠李玲玲
Owner 崔铠
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