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Licorrhizin injection and its preparation method and application

A liquiritigenin and injection technology, which can be used in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc., can solve the problems of serious first-pass effect and low bioavailability of oral preparations of liquiritigenin , to achieve the effects of safe and reliable clinical use, high bioavailability, and prevention of oxidative decomposition

Active Publication Date: 2016-04-20
NANJING HAICHANG CHINESE MEDICINE GRPCO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Purpose of the invention: the purpose of the present invention is to solve the deficiency of oral preparations of liquiritigenin in the prior art, provide a kind of liquiritigenin injection and its preparation method, to solve the problem of serious first-pass effect and low bioavailability of oral preparations of liquiritigenin

Method used

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  • Licorrhizin injection and its preparation method and application
  • Licorrhizin injection and its preparation method and application
  • Licorrhizin injection and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] 1. A glycyrrhizin injection, each 100 mL of glycyrrhizin injection contains 50 mg of glycyrrhizin, 40 mL of propylene glycol, the rest is water for injection, and the pH is 4.0-6.0.

[0051] 2. The preparation method of glycyrrhizin injection, which includes the following steps:

[0052] First take 50mg of glycyrrhizin, stir until it is completely dissolved in 40mL of propylene glycol, add 60mL of water for injection, and then use a 5000 Dalton hollow fiber ultrafiltration membrane for ultrafiltration, after filtration, adjust the pH to 4.0-6.0 with hydrochloric acid or sodium hydroxide , After filling with nitrogen, filling and sealing in an ampoule, and then sterilizing at 121℃, 0.11MPa hot pressure for 15min. Example 2

Embodiment 2

[0053] 1. A glycyrrhizin injection, each 100 mL of glycyrrhizin injection contains 10 mg of glycyrrhizin, 20 mL of propylene glycol, and the rest is water for injection, with a pH of 4.0 to 6.0.

[0054] 2. The preparation method of glycyrrhizin injection, which includes the following steps:

[0055] First take 10mg of glycyrrhizin, stir until it is completely dissolved in 20mL of propylene glycol, add 80mL of water for injection, and then use a 5000 Dalton hollow fiber ultrafiltration membrane for ultrafiltration, after filtration, adjust the pH to 4.0-6.0 with hydrochloric acid or sodium hydroxide , After filling with nitrogen, filling and sealing in an ampoule, and then sterilizing at 121℃, 0.11MPa hot pressure for 15min. Example 3

Embodiment 3

[0056] 1. A glycyrrhizin injection, each 100 mL glycyrrhizin injection contains 500 mg of glycyrrhizin, 50 mL of propylene glycol, and the rest is water for injection, and the pH is 4.0-6.0.

[0057] 2. The preparation method of glycyrrhizin injection, which includes the following steps:

[0058] First take 500 mg of glycyrrhizin, stir until it is completely dissolved in 50 mL of propylene glycol, add 50 mL of water for injection, and then use a 5000 Dalton hollow fiber ultrafiltration membrane for ultrafiltration, after filtration, adjust the pH to 4.0-6.0 with hydrochloric acid or sodium hydroxide , After filling with nitrogen, filling and sealing in an ampoule, and then sterilizing at 121℃, 0.11MPa hot pressure for 15min. Example 4

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Abstract

The invention discloses a liquiritigenin injection and a preparation method and application thereof. Each 100mL of liquiritigenin injection provided by the invention contains 10mg-1000mg of liquiritigenin, 20-50mL of propylene glycol and the balance of injection water; the liquiritigenin injection has a pH value of 4.0-6.0. According to the liquiritigenin injection, through a plenty of experiments, the dissolving solvent and the consumption thereof of the liquiritigenin injection, the concentration of liquiritigenin, and the pH value of the injection are screened, and thus an optimal injection formula is obtained; meanwhile, according to the solubility, the stability, the vascular stimulation, the hemolysis and the like, a preparation process of the liquiritigenin injection is screened. Experiments indicate that the liquiritigenin injection prepared by adopting the preparation method is small in irritation, free from hemolytic activity, high in safety, especially better in stability, strong in anti-tumor activity, capable of overcoming the defects of serious first-pass effect, low bioavailability and the like of an existing preparation, and better in clinical effect.

Description

Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and specifically relates to a glycyrrhizin injection with excellent stability and multiple anti-tumor effects and a preparation method thereof. Background technique [0002] Malignant tumor is one of the diseases that seriously threaten human health and life. It has the characteristics of long treatment course, difficult to cure, heavy economic and spiritual burden, etc., which brings a heavy burden to patients and society. Since the 1970s, the incidence of cancer in my country has been on an upward trend. About 2 million people suffer from cancer each year, and more than 1.4 million people die from cancer. Among them, the high incidence of liver cancer is very serious, and the death rate is the third highest among cancer deaths. 110,000 people die from liver cancer each year, accounting for about 45% of the world's total deaths from liver cancer. In this regard, the can...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/352A61K47/10A61P35/00A61P35/02
Inventor 蔡云清蔡宝昌顾杰姚仲青秦昆明张金龙刘晓
Owner NANJING HAICHANG CHINESE MEDICINE GRPCO LTD
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