Avian influenza H9 subtype inactivated vaccine, preparation method and application thereof

An inactivated vaccine, avian influenza technology, applied in biochemical equipment and methods, microorganism-based methods, pharmaceutical formulations, etc. Drop and other problems, to achieve the effect of good attack protection, stable efficacy and strong immunogenicity
CN103736088BActive Publication Date: 2015-07-15ZHAOQING DAHUANONG BIOLOGIC PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZHAOQING DAHUANONG BIOLOGIC PHARMA
Publication Date
2015-07-15

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Abstract

The present invention relates to an avian influenza H9 subtype inactivated vaccine, which is formed by mixing two strains of inactivated H9 subtype avian influenza viruses and an oil adjuvant, wherein the two strains of the inactivated H9 subtype avian influenza viruses are respectively the HZ strain and the FJ strain, the HA gene sequence of the HZ strain is represented by SEQ ID NO:1, and the HA gene sequence of the FJ strain is represented by SEQ ID NO:2. According to the preparation method, the virus solution of the HZ strain and the virus solution of the FJ strain of the H9 subtype avian influenza viruses are prepared and inactivated, the oil phase solution and the water phase solution are prepared, and emulsification is performed to obtain the finished product. According to the present invention, the two strains of the H9 subtype avian influenza viruses separated from different places are utilized to prepare the inactivated vaccine with characteristics of strong immunogenicity and good cross-protection property, wherein the inactivated vaccine can be used for prevention of chicken H9 subtype avian influenza diseases. In addition, after the inactivated vaccine is adopted to immunize chicken, the antibody titer is high so as to make the chicken have good virus challenge protection property on the H9 subtype strains epidemic in different places, the safety is high, and the efficacy is stable.
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Description

technical field

[0001] The invention belongs to the technical field of biological products for animals, and in particular relates to an inactivated avian influenza H9 subtype vaccine and a preparation method and application thereof. Background technique

[0002] Avian Influenza (AI) is a general term for poultry infections and diseases caused by type A influenza viruses of the genus Influenzavirus. Poultry such as chickens, turkeys, ducks, and quails, as well as wild birds, waterfowl, and seabirds can be infected, and the harm caused to domestic chickens and turkeys is the most serious. The main reason for the worldwide epidemic of influenza, pigs can also be used as "mixers" to spread the disease.

[0003] According to the difference in pathogenicity of avian influenza virus AIV to birds, AIV can be divided into highly pathogenic avian influenza virus (HPAIV) and low pathogenic avian influenza virus (LPAIV). H9 subtype avian influenza belongs to low pathogenicity influenz...

Claims

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