Method for manufacturing composition comprising local anesthetic, heparinoid, and buffer

A technology for local anesthetics and buffers, applied in the field of manufacturing compositions containing local anesthetics, heparin and buffers, which can solve the problems of reducing bioavailability and reducing the efficacy of the composition

Inactive Publication Date: 2014-04-23
C·洛维尔·帕森斯
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Precipitation of lidocaine reduces its bioavailability and reduces the efficacy of the composition

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0105] The following experiments were carried out to test the efficacy of compositions prepared according to the present invention and compare them with compositions prepared by existing methods.

[0106] Solution 1 was prepared as follows: Commercially available heparin, lidocaine (approved by the FDA for human use) was mixed as follows: 5 ml of heparin solution containing 50,000 units of heparin, 5 ml of 4% lidocaine (200 mg), and 2 ml of 8. 4% sodium bicarbonate (168 mg) was mixed in such a way that the heparin and bicarbonate were added together, followed by the last addition of lidocaine to give a final pH of 7.4. The solution became cloudy after 2-3 minutes, indicating loss of lidocaine from solution.

[0107] Solution 2 was prepared as follows: powdered sodium heparin (50,000 units) and powdered lidocaine hydrochloride (200 mg) were dissolved in a total of 13 ml of water, then 2 ml of 8.4% sodium bicarbonate (168 mg) was added to obtain a final pH of 7.4. The solution ...

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Abstract

An improved method for preparing a composition including a heparinoid, a local anesthetic, and a buffer for treatment and used for treating a lower urinary tract disease or condition, can comprise: (i) providing a heparinoid in solid form or liquid form; (ii) providing a local anesthetic in solid form or liquid form; (iii) adding a liquid buffer to the heparinoid in solid form or liquid form; (Iv) adding the local anesthetic to the mixture of the liquid buffer and the heparinoid; and (v) if necessary, adjusting the pH of the mixture of the liquid buffer, the local anesthetic, and the heparinoid so that a pH from about 6.8 to about 8.3 is achieved without precipitation of the local anesthetic.

Description

[0001] cross reference [0002] This application claims the patent application entitled "Method for Manufacturing Composition Comprising Local Anesthetic, Heparinoid, and Buffer" filed January 6, 2011 by C. Lowell Parsons Priority to US Provisional Application Serial No. 61 / 430,468, the contents of which are hereby incorporated by reference in their entirety. technical field [0003] The present invention relates to improved methods for the manufacture of compositions suitable for the treatment of bladder symptoms observed in interstitial cystitis and other lower urinary tract disorders such as, but not limited to, overactive bladder, prostate inflammation, urethral syndrome in women, and gynecological chronic pelvic pain. The composition comprises a local anesthetic, a glycosaminoglycan and a buffer, the local anesthetic is usually lidocaine, the glycosaminoglycan is usually heparin, the buffer is usually sodium bicarbonate, and then the combination The drug is instilled di...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/727
CPCA61K31/727A61K31/167A61K45/06A61P13/00A61P13/02A61P13/08A61P13/10A61P15/00A61P15/02A61P23/02A61P25/04A61K2300/00A61K9/0034
Inventor C·洛维尔·帕森斯
Owner C·洛维尔·帕森斯
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