Method for manufacturing composition comprising local anesthetic, heparinoid, and buffer

Abstract

An improved method for preparing a composition including a heparinoid, a local anesthetic, and a buffer for treatment and used for treating a lower urinary tract disease or condition, can comprise: (i) providing a heparinoid in solid form or liquid form; (ii) providing a local anesthetic in solid form or liquid form; (iii) adding a liquid buffer to the heparinoid in solid form or liquid form; (Iv) adding the local anesthetic to the mixture of the liquid buffer and the heparinoid; and (v) if necessary, adjusting the pH of the mixture of the liquid buffer, the local anesthetic, and the heparinoid so that a pH from about 6.8 to about 8.3 is achieved without precipitation of the local anesthetic.

Description

[0001] cross reference [0002] This application claims the patent application entitled "Method for Manufacturing Composition Comprising Local Anesthetic, Heparinoid, and Buffer" filed January 6, 2011 by C. Lowell Parsons Priority to US Provisional Application Serial No. 61 / 430,468, the contents of which are hereby incorporated by reference in their entirety. technical field [0003] The present invention relates to improved methods for the manufacture of compositions suitable for the treatment of bladder symptoms observed in interstitial cystitis and other lower urinary tract disorders such as, but not limited to, overactive bladder, prostate inflammation, urethral syndrome in women, and gynecological chronic pelvic pain. The composition comprises a local anesthetic, a glycosaminoglycan and a buffer, the local anesthetic is usually lidocaine, the glycosaminoglycan is usually heparin, the buffer is usually sodium bicarbonate, and then the combination The drug is instilled di...

AI Technical Summary

Problems solved by technology

Precipitation of lidocaine reduces its bioavailability and reduces the efficacy of the composition