Preparation method of injectable porous calcium phosphate bone repair material

A calcium phosphate bone and repair material technology, applied in the field of medical materials, can solve the problems of not meeting the requirements of bone tissue engineering scaffold materials, long setting time of calcium phosphate bone cement, poor mechanical properties, etc., to improve application comfort and setting time Short, high compressive strength effect

Inactive Publication Date: 2014-05-28
张宪 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Calcium phosphate cement (CPC) has the disadvantages of long setting time, poor mechanical propert

Method used

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  • Preparation method of injectable porous calcium phosphate bone repair material
  • Preparation method of injectable porous calcium phosphate bone repair material
  • Preparation method of injectable porous calcium phosphate bone repair material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] (1) Treat calcium hydrogen phosphate dihydrate at 120°C for 12 hours, sieve after cooling, and then put it into a ball mill, add agate balls and absolute ethanol, ball mill on the ball mill for 12 hours, and dry it in a drying oven at 80°C drying in medium to obtain anhydrous calcium hydrogen phosphate;

[0036] (2) dissolving chitosan, citric acid, and glucose in deionized water in proportions of 3%, 5%, and 15% by mass, stirring and dissolving, forming a solution, standing for 24 hours, and setting aside;

[0037] (3) Put mannitol in the ethanol solution, heat and stir to make it fully dissolved, the volume ratio of mannitol to ethanol is 2:1, then let stand and cool to obtain recrystallized mannitol crystals, and recrystallize The final mannitol crystals were vacuum filtered, dried, passed through a 50-mesh sieve and a 150-mesh sieve respectively, and set aside;

[0038] (4) The liquid phase adopts the solution configured in step (2), and the solid phase is composed...

Embodiment 2

[0041] (1) Dibasic calcium phosphate dihydrate was treated at 120°C for 12 hours, cooled and sieved, then put into a ball mill, added agate balls and absolute ethanol, ball milled on the ball mill for 12 hours, and dried in a drying oven at 80°C drying in medium to obtain anhydrous calcium hydrogen phosphate;

[0042] (2) dissolving chitosan, citric acid, and glucose in deionized water in proportions of 5%, 8%, and 20% by mass, stirring and dissolving, forming a solution, standing for 24 hours, and setting aside;

[0043] (3) Put mannitol in the ethanol solution, heat and stir to make it fully dissolved, the volume ratio of mannitol to ethanol is 1:1, then let stand and cool to obtain recrystallized mannitol crystals, and recrystallize The final mannitol crystals were vacuum filtered, dried, passed through a 50-mesh sieve and a 150-mesh sieve respectively, and set aside;

[0044] (4) The liquid phase adopts the solution configured by step (2), and the solid phase is composed ...

Embodiment 3

[0047] (1) Treat calcium hydrogen phosphate dihydrate at 120°C for 12 hours, sieve after cooling, and then put it into a ball mill, add agate balls and absolute ethanol, ball mill on the ball mill for 12 hours, and dry it in a drying oven at 80°C drying in medium to obtain anhydrous calcium hydrogen phosphate;

[0048] (2) dissolving chitosan, citric acid, and glucose in deionized water in proportions of 1%, 8%, and 10% by mass percentage, stirring and dissolving, forming a solution, standing for 24 hours, and setting aside;

[0049] (3) Put mannitol in the ethanol solution, heat and stir to make it fully dissolved, the volume ratio of mannitol to ethanol is 3:1, then let stand and cool to obtain recrystallized mannitol crystals, and recrystallize The final mannitol crystals were vacuum filtered, dried, passed through a 50-mesh sieve and a 150-mesh sieve respectively, and set aside;

[0050](4) The liquid phase adopts the solution configured in step (2), and the solid phase i...

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Abstract

The invention discloses a preparation method of an injectable porous calcium phosphate bone repair material. the method provided by the invention is as follows: dicalicium phosphate anhydrous is firstly prepared while chitosan, citric acid and a glucose solution are prepared; mannitol crystals are prepared for later use; chitosan, citric acid and the glucose solution are adopted as a liquid phase, and tetracalcium phosphate and dicalicium phosphate anhydrous are adopted as a solid phase; a pore-forming agent which is composed of mannitol and a polylactic acid-glycolic acid copolymer is added into the solid phase; the solid phase and the liquid phase are successively added into a small culture dish and rapidly stirred with a glass rod for 1-2min so as to form uniform pulp; and the mixture initially has injectable performance, and the porous bone repair material is formed after solidification of the mixture. The repair material prepared by the method has advantages of short solidification time and high compressive strength. Through SEM observation of surface morphology, communication between pores is good. By the preparation method, plasticity and viscoelasticity of CPC can be raised, bone cement is endowed with injectable performance, and application range and application comfort level of bone cement are raised greatly.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a preparation method of an injectable porous calcium phosphate bone repair material. Background technique [0002] With the deepening of research in the field of medical materials, bone tissue repair materials, especially calcium-phosphorus materials, have attracted increasing attention. They have good biocompatibility, good osteoconductivity and osteoinductive potential, and are widely used in bone repair. has great potential for clinical application. However, it has poor mechanical properties, [0003] The shortcomings of long solidification time, low porosity and slow degradation cannot meet the relevant requirements of scaffold materials for bone tissue engineering. [0004] Calcium phosphate cement (CPC) has the disadvantages of long setting time, poor mechanical properties and low porosity, which cannot meet the requirements of scaffold materials for bone tissue...

Claims

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Application Information

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IPC IPC(8): A61L27/42A61L27/56A61L27/50
Inventor 张宪张亮郑江
Owner 张宪
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